Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation FAM110B_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-15173 | FAM110B | down-regulates | VENTX | activates | R-3320 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15174 | FAM110B | down-regulates | ELF5 | activates | R-3348 | 16 | 1 | Drugs (1) |
| CMF-15178 | FAM110B | up-regulates | TCF4 | represses | R-1608 | 17 | 4 | Drugs (1) |
| CMF-15179 | FAM110B | up-regulates | TCF4 | represses | R-1613 | 17 | 4 | Drugs (4) |
| CMF-15182 | FAM110B | down-regulates | IRF8 | activates | R-397 | 18 | 1 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-15183 | FAM110B | down-regulates | EHF | activates | R-3346 | 3 | 1 | Drugs (3) |
| CMF-15184 | FAM110B | down-regulates | CPEB1 | activates | R-3792 | 3 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38056 | FAM110B | up-regulates | hsa-mir-139 | represses | R-117 | 58 | 8 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-38057 | FAM110B | up-regulates | hsa-mir-139 | represses | R-397 | 58 | 8 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-38058 | FAM110B | up-regulates | hsa-mir-139 | represses | R-419 | 58 | 8 | Drugs (2) |
| CMF-38059 | FAM110B | up-regulates | hsa-mir-139 | represses | R-2585 | 58 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-38060 | FAM110B | up-regulates | hsa-mir-139 | represses | R-2885 | 58 | 8 | Drugs (1) |
| CMF-38061 | FAM110B | up-regulates | hsa-mir-139 | represses | R-3134 | 58 | 8 | Drugs (1) |
| CMF-38062 | FAM110B | up-regulates | hsa-mir-139 | represses | R-3348 | 58 | 8 | Drugs (1) |
| CMF-38063 | FAM110B | up-regulates | hsa-mir-139 | represses | R-1592 | 58 | 8 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |