Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
TCF4 - transcription factor 4
Function
Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 6925 | ENSG00000196628 | TCF4 | P15884 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000196628 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-06097 | FGFR3 | down-regulates | TCF4 | represses | R-1608 | 17 | 4 | Drugs (1) |
| CMF-06098 | FGFR3 | down-regulates | TCF4 | represses | R-1613 | 17 | 4 | Drugs (4) |
| CMF-07054 | ATRX | up-regulates | TCF4 | represses | R-1608 | 17 | 10 | Drugs (1) |
| CMF-07055 | ATRX | up-regulates | TCF4 | represses | R-1613 | 17 | 10 | Drugs (4) |
| CMF-07586 | AHNAK2 | up-regulates | TCF4 | represses | R-1608 | 17 | 3 | Drugs (1) |
| CMF-07587 | AHNAK2 | up-regulates | TCF4 | represses | R-1613 | 17 | 3 | Drugs (4) |
| CMF-07695 | PLCXD3 | up-regulates | TCF4 | represses | R-1613 | 17 | 1 | Drugs (4) |
| CMF-13214 | SLC26A8 | up-regulates | TCF4 | activates | R-1611 | 17 | 2 | Drugs (2) |
| CMF-15178 | FAM110B | up-regulates | TCF4 | represses | R-1608 | 17 | 4 | Drugs (1) |
| CMF-15179 | FAM110B | up-regulates | TCF4 | represses | R-1613 | 17 | 4 | Drugs (4) |
| CMF-16581 | RBM19 | down-regulates | TCF4 | activates | R-1622 | 17 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16584 | RBM19 | down-regulates | TCF4 | activates | R-1611 | 17 | 5 | Drugs (2) |
| CMF-17257 | MAP3K7 | up-regulates | TCF4 | activates | R-1611 | 17 | 4 | Drugs (2) |
| CMF-17399 | TBC1D8 | up-regulates | TCF4 | represses | R-1613 | 17 | 2 | Drugs (4) |
| CMF-17685 | MRPL32 | up-regulates | TCF4 | represses | R-1613 | 17 | 2 | Drugs (4) |
| CMF-19121 | LRP1B | up-regulates | TCF4 | activates | R-1611 | 17 | 2 | Drugs (2) |
| CMF-20455 | CUX2 | up-regulates | TCF4 | activates | R-1622 | 17 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21230 | ESPL1 | up-regulates | TCF4 | represses | R-1613 | 17 | 2 | Drugs (4) |
| CMF-21975 | MRGPRE | up-regulates | TCF4 | represses | R-1613 | 17 | 2 | Drugs (4) |
| CMF-22812 | IDH1 | up-regulates | TCF4 | represses | R-1608 | 17 | 10 | Drugs (1) |
| CMF-22814 | IDH1 | up-regulates | TCF4 | represses | R-1613 | 17 | 10 | Drugs (4) |
| CMF-24209 | OR4K5 | up-regulates | TCF4 | represses | R-1608 | 17 | 2 | Drugs (1) |
| CMF-25162 | FLT3 | up-regulates | TCF4 | activates | R-1622 | 17 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25740 | TMC1 | up-regulates | TCF4 | represses | R-1613 | 17 | 2 | Drugs (4) |
| CMF-26761 | RB1 | down-regulates | TCF4 | activates | R-1611 | 17 | 5 | Drugs (2) |
| CMF-29694 | ESRRB | down-regulates | TCF4 | activates | R-1622 | 17 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29697 | ESRRB | down-regulates | TCF4 | represses | R-1608 | 17 | 6 | Drugs (1) |
| CMF-29699 | ESRRB | down-regulates | TCF4 | activates | R-1611 | 17 | 6 | Drugs (2) |
| CMF-30433 | DVL2 | up-regulates | TCF4 | represses | R-1613 | 17 | 2 | Drugs (4) |
| CMF-31177 | LRFN2 | up-regulates | TCF4 | represses | R-1608 | 17 | 6 | Drugs (1) |
| CMF-31178 | LRFN2 | up-regulates | TCF4 | represses | R-1613 | 17 | 6 | Drugs (4) |