Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
EHF - ETS homologous factor
Function
Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 26298 | ENSG00000135373 | EHF | Q9NZC4 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000135373 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-06064 | OTOA | down-regulates | EHF | activates | R-3345 | 3 | 1 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-06618 | CACNA1D | down-regulates | EHF | activates | R-3346 | 3 | 1 | Drugs (3) |
| CMF-12103 | NOX3 | down-regulates | EHF | activates | R-3346 | 3 | 1 | Drugs (3) |
| CMF-15183 | FAM110B | down-regulates | EHF | activates | R-3346 | 3 | 1 | Drugs (3) |
| CMF-20929 | RXFP1 | down-regulates | EHF | activates | R-3346 | 3 | 1 | Drugs (3) |
| CMF-21854 | ITSN1 | down-regulates | EHF | activates | R-3346 | 3 | 1 | Drugs (3) |
| CMF-24885 | NSUN5 | down-regulates | EHF | activates | R-3345 | 3 | 1 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |