Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation ABCA4_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-02090 | ABCA4 | up-regulates | SRF | activates | R-1140 | 18 | 6 | Drugs (1) |
| CMF-02094 | ABCA4 | up-regulates | SRF | activates | R-1138 | 18 | 6 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR |
| CMF-02095 | ABCA4 | up-regulates | SRF | activates | R-1129 | 18 | 6 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-02097 | ABCA4 | up-regulates | BPTF | activates | R-2864 | 21 | 4 | Drugs (2) |
| CMF-02103 | ABCA4 | down-regulates | LMX1B | represses | R-2931 | 11 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02107 | ABCA4 | up-regulates | IRF7 | activates | R-2479 | 21 | 4 | Drugs (2) |
| CMF-02108 | ABCA4 | up-regulates | IRF7 | activates | R-2491 | 21 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02109 | ABCA4 | up-regulates | IRF7 | activates | R-2492 | 21 | 4 | Drugs (1) |
| CMF-02114 | ABCA4 | up-regulates | SOX9 | activates | R-1225 | 16 | 3 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-02121 | ABCA4 | up-regulates | BCL6 | activates | R-635 | 23 | 4 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR |
| CMF-02126 | ABCA4 | up-regulates | JUN | activates | R-231 | 25 | 3 | Drugs (2) |
| CMF-02137 | ABCA4 | up-regulates | YY1 | activates | R-62 | 25 | 5 | Drugs (3) |
| CMF-02155 | ABCA4 | down-regulates | FOXC2 | represses | R-2652 | 11 | 2 | Drugs (1) |
| CMF-02157 | ABCA4 | up-regulates | FOXO3 | activates | R-752 | 24 | 4 | Drugs (1) |
| CMF-02168 | ABCA4 | up-regulates | MSX1 | activates | R-2817 | 12 | 2 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)AMG-780, MEDI-3617, F16SIP 131I, TREBANANIB, F16IL2, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-02169 | ABCA4 | down-regulates | TRAF4 | activates | R-2273 | 14 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02170 | ABCA4 | up-regulates | STAT1 | activates | R-2465 | 21 | 3 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)PONEZUMAB, CRENEZUMAB, ELIGLUSTAT, GANTENERUMAB, SOLANEZUMAB, ELIGLUSTAT TARTRATE, MIGLUSTAT, BAPINEUZUMAB, GSK933776, SATRALIZUMAB, LUCERASTAT, ADUCANUMAB, TRAMIPROSATE, LECANEMAB, DONANEMAB, VANUTIDE CRIDIFICAR |
| CMF-02172 | ABCA4 | up-regulates | STAT1 | activates | R-2454 | 21 | 3 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)DANVATIRSEN, EDASALONEXENT, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, TOSEDOSTAT, DESLANOSIDE, ISTAROXIME |