Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
FOXO3 - forkhead box O3
Function
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Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 2309 | ENSG00000118689 | FOXO3 | A0A856PRE8 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000118689 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00123 | LRP2 | up-regulates | FOXO3 | activates | R-738 | 24 | 7 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-00124 | LRP2 | up-regulates | FOXO3 | represses | R-748 | 24 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00125 | LRP2 | up-regulates | FOXO3 | activates | R-752 | 24 | 7 | Drugs (1) |
| CMF-00869 | MUC2 | down-regulates | FOXO3 | represses | R-748 | 24 | 10 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01564 | CACNA1B | up-regulates | FOXO3 | activates | R-738 | 24 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-02157 | ABCA4 | up-regulates | FOXO3 | activates | R-752 | 24 | 4 | Drugs (1) |
| CMF-03063 | OR5D14 | up-regulates | FOXO3 | activates | R-738 | 24 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-06030 | DUOX2 | up-regulates | FOXO3 | represses | R-748 | 24 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06250 | CYP4X1 | up-regulates | FOXO3 | represses | R-748 | 24 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07354 | NOD2 | up-regulates | FOXO3 | activates | R-738 | 24 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-08387 | C9orf131 | down-regulates | FOXO3 | activates | R-738 | 24 | 7 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-08405 | NIPBL | up-regulates | FOXO3 | represses | R-748 | 24 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08989 | GPR132 | up-regulates | FOXO3 | activates | R-738 | 24 | 5 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-09912 | CD163L1 | up-regulates | FOXO3 | represses | R-748 | 24 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-10086 | ATP8A2 | up-regulates | FOXO3 | represses | R-737 | 24 | 4 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-10861 | PKD1L2 | up-regulates | FOXO3 | represses | R-737 | 24 | 4 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-13603 | FMN1 | up-regulates | FOXO3 | activates | R-738 | 24 | 16 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-13608 | FMN1 | up-regulates | FOXO3 | activates | R-752 | 24 | 16 | Drugs (1) |
| CMF-15036 | TG | up-regulates | FOXO3 | represses | R-748 | 24 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17015 | ZNF804A | up-regulates | FOXO3 | activates | R-752 | 24 | 1 | Drugs (1) |
| CMF-17841 | CSF2RB | up-regulates | FOXO3 | represses | R-748 | 24 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-19674 | RPSAP58 | down-regulates | FOXO3 | represses | R-737 | 24 | 2 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-20168 | ITPR1 | down-regulates | FOXO3 | represses | R-748 | 24 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20835 | POTEG | up-regulates | FOXO3 | represses | R-748 | 24 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22871 | IDH1 | up-regulates | FOXO3 | represses | R-737 | 24 | 18 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-24017 | TP53 | up-regulates | FOXO3 | represses | R-737 | 24 | 12 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-24731 | SLC4A5 | up-regulates | FOXO3 | activates | R-738 | 24 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-26896 | ARMC3 | up-regulates | FOXO3 | represses | R-748 | 24 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27350 | CHD5 | up-regulates | FOXO3 | activates | R-738 | 24 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-27351 | CHD5 | up-regulates | FOXO3 | activates | R-752 | 24 | 3 | Drugs (1) |
| CMF-27970 | CXorf22 | up-regulates | FOXO3 | activates | R-738 | 24 | 8 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)TAS0612, LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-28235 | REPIN1 | up-regulates | FOXO3 | activates | R-752 | 24 | 1 | Drugs (1) |
| CMF-28524 | STXBP5L | up-regulates | FOXO3 | represses | R-748 | 24 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28707 | TRPS1 | up-regulates | FOXO3 | represses | R-748 | 24 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28717 | TSHZ2 | up-regulates | FOXO3 | represses | R-748 | 24 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28909 | NR1H4 | down-regulates | FOXO3 | represses | R-737 | 24 | 7 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-29096 | TUBB4Q | up-regulates | FOXO3 | represses | R-748 | 24 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29708 | ESRRB | down-regulates | FOXO3 | activates | R-752 | 24 | 8 | Drugs (1) |
| CMF-30412 | FGB | up-regulates | FOXO3 | represses | R-748 | 24 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30545 | JHDM1D | down-regulates | FOXO3 | activates | R-752 | 24 | 5 | Drugs (1) |