Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
YY1 - YY1 transcription factor
Function
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 7528 | ENSG00000100811 | YY1 | P25490 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000100811 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-02137 | ABCA4 | up-regulates | YY1 | activates | R-62 | 25 | 5 | Drugs (3) |
| CMF-02637 | LBP | up-regulates | YY1 | activates | R-59 | 25 | 6 | Drugs (3) |
| CMF-03113 | DNAH8 | up-regulates | YY1 | activates | R-59 | 25 | 1 | Drugs (3) |
| CMF-03915 | DSP | up-regulates | YY1 | activates | R-62 | 25 | 8 | Drugs (3) |
| CMF-04283 | RBPJL | up-regulates | YY1 | activates | R-62 | 25 | 2 | Drugs (3) |
| CMF-05529 | IL18RAP | up-regulates | YY1 | activates | R-75 | 25 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09794 | OR51A2 | up-regulates | YY1 | activates | R-62 | 25 | 3 | Drugs (3) |
| CMF-12322 | GPR98 | down-regulates | YY1 | activates | R-61 | 25 | 3 | Drugs (1) |
| CMF-15190 | ERCC6 | down-regulates | YY1 | activates | R-61 | 25 | 2 | Drugs (1) |
| CMF-15854 | ZNF845 | up-regulates | YY1 | activates | R-75 | 25 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16290 | COBLL1 | up-regulates | YY1 | activates | R-62 | 25 | 2 | Drugs (3) |
| CMF-19443 | NF1 | up-regulates | YY1 | activates | R-61 | 25 | 5 | Drugs (1) |
| CMF-19445 | NF1 | up-regulates | YY1 | activates | R-62 | 25 | 5 | Drugs (3) |
| CMF-20515 | BCL11A | down-regulates | YY1 | activates | R-59 | 25 | 5 | Drugs (3) |
| CMF-20517 | BCL11A | down-regulates | YY1 | activates | R-61 | 25 | 5 | Drugs (1) |
| CMF-23898 | TP53 | up-regulates | YY1 | activates | R-75 | 25 | 14 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24203 | OR4K5 | up-regulates | YY1 | activates | R-75 | 25 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24664 | UGT2A3 | up-regulates | YY1 | activates | R-75 | 25 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25788 | FZD10 | down-regulates | YY1 | activates | R-61 | 25 | 5 | Drugs (1) |
| CMF-26252 | SLITRK2 | down-regulates | YY1 | activates | R-61 | 25 | 2 | Drugs (1) |
| CMF-26253 | SLITRK2 | down-regulates | YY1 | activates | R-62 | 25 | 2 | Drugs (3) |
| CMF-28729 | POF1B | up-regulates | YY1 | activates | R-62 | 25 | 3 | Drugs (3) |
| CMF-29315 | C12orf51 | up-regulates | YY1 | activates | R-62 | 25 | 6 | Drugs (3) |
| CMF-30226 | TEP1 | up-regulates | YY1 | activates | R-75 | 25 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |