Regulon

Regulon: R-600

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
25	2.0764	1	1	Pr-40

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
2137	ENSG00000012232	EXTL3	O43909
54929	ENSG00000064545	TMEM161A	Q9NX61
28951	ENSG00000071575	TRIB2	Q92519
23209	ENSG00000100427	MLC1	Q15049
9770	ENSG00000101265	RASSF2	P50749
1471	ENSG00000101439	CST3	P01034
56062	ENSG00000102271	KLHL4	Q9C0H6
4223	ENSG00000106511	MEOX2	P50222
6662	ENSG00000125398	SOX9	P48436
5786	ENSG00000132670	PTPRA	P18433
10253	ENSG00000136158	SPRY2	O43597
6744	ENSG00000138434	SSFA2	P28290
1956	ENSG00000146648	EGFR	P00533
64067	ENSG00000151322	NPAS3	Q8IXF0
10252	ENSG00000164056	SPRY1	O43609
308	ENSG00000164111	ANXA5	P08758
1000	ENSG00000170558	CDH2	P19022
3913	ENSG00000172037	LAMB2	P55268
1605	ENSG00000173402	DAG1	Q14118
10186	ENSG00000183722	LHFP	Q9Y693
81848	ENSG00000187678	SPRY4	Q9C004
54413	ENSG00000196338	NLGN3	X5D2P6
54898	ENSG00000197977	ELOVL2	Q9NXB9
23237	ENSG00000198576	ARC	Q7LC44
113178	ENSG00000227500	SCAMP4	Q969E2

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
POZIOTINIB	ERBB2	Small molecule	INHIBITOR	Epidermal growth factor receptor inhibitor	2	0
VARLITINIB	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	2	0
CUDC-101	HDAC1	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	1	0
LAPATINIB DITOSYLATE	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	4	0
DULIGOTUZUMAB	ERBB3	Antibody	INHIBITOR	Receptor tyrosine-protein kinase erbB-3 inhibitor	2	0
FUTUXIMAB	EGFR	Antibody	ANTAGONIST	Epidermal growth factor receptor erbB1 antagonist	3	2
NAZARTINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
MP-412	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	1	0
NIMOTUZUMAB	EGFR	Antibody	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	3	3
TOMUZOTUXIMAB	EGFR	Antibody	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
ROCILETINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	3	0
CANERTINIB DIHYDROCHLORIDE	ERBB4	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	3	0
NERATINIB MALEATE	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-4 inhibitor	4	0
MOBOCERTINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	4	0
GEFITINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	4	2
CEP-32496	EGFR	Small molecule	INHIBITOR	Serine/threonine-protein kinase B-raf inhibitor	1	0
LAPATINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	4	0
ALMONERTINIB	EGFR	Unknown	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	3	0
BRIGATINIB	ALK	Small molecule	INHIBITOR	ALK tyrosine kinase receptor inhibitor	4	0
EPITINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	1	1
SAPITINIB	EGFR	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	2	0
NERATINIB	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	4	2
BMS-690514	KDR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
PELITINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
AC-480	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	1	0
PANITUMUMAB	EGFR	Antibody	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	4	0
DACOMITINIB	EGFR	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-4 inhibitor	4	2
ABIVERTINIB	BTK	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	3	0
KBP5209	ERBB2	Unknown	INHIBITOR	Epidermal growth factor receptor inhibitor	1	0
TARLOXOTINIB	ERBB2	Small molecule	INHIBITOR	Epidermal growth factor receptor inhibitor	2	0
ABIVERTINIB MALEATE	EGFR	Small molecule	INHIBITOR	Tyrosine-protein kinase BTK inhibitor	3	0
DEPATUXIZUMAB	EGFR	Antibody	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
ALFLUTINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
SIMOTINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	3	0
PF-06459988	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
THELIATINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	1	0
VANDETANIB	EPHA2	Small molecule	INHIBITOR	Tyrosine-protein kinase SRC inhibitor	4	2
ALLITINIB	ERBB2	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
DEPATUXIZUMAB MAFODOTIN	EGFR	Antibody	BINDING AGENT	Epidermal growth factor receptor erbB1 binding agent	3	3
OLMUTINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
CLN-081	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	1	0
AZD-3759	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
OSIMERTINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	4	2
MAB-425	EGFR	Antibody	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
CANERTINIB	ERBB4	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	3	0
BDTX189	EGFR	Small molecule	NEGATIVE ALLOSTERIC MODULATOR	Epidermal growth factor receptor erbB1 negative allosteric modulator	1	0
AMIVANTAMAB	MET	Antibody	INHIBITOR	Hepatocyte growth factor receptor inhibitor	4	0
GC1118	EGFR	Antibody	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	2
JNJ-26483327	ERBB2	Small molecule	INHIBITOR	Tyrosine-protein kinase FYN inhibitor	1	0
TESEVATINIB	ERBB2	Small molecule	INHIBITOR	Ephrin type-B receptor 4 inhibitor	3	2
NECITUMUMAB	EGFR	Antibody	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	4	0
MATUZUMAB	EGFR	Antibody	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
ZALUTUMUMAB	EGFR	Antibody	ANTAGONIST	Epidermal growth factor receptor erbB1 antagonist	3	0
FALNIDAMOL	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	1	0
ERLOTINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	4	2
AFATINIB DIMALEATE	EGFR	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	4	0
IMGATUZUMAB	EGFR	Antibody	CROSS-LINKING AGENT	Low affinity immunoglobulin gamma Fc region receptor III-A cross-linking agent	2	0
AFATINIB	ERBB2	Small molecule	INHIBITOR	Receptor protein-tyrosine kinase erbB-2 inhibitor	4	1
CETUXIMAB	EGFR	Antibody	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	4	2
RINDOPEPIMUT	EGFR	Unknown	VACCINE ANTIGEN	Epidermal growth factor receptor erbB1 vaccine antigen	3	2
NAQUOTINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	3	0
OCRIPLASMIN	LAMA2	Enzyme	PROTEOLYTIC ENZYME	Fibronectin proteolytic enzyme	4	0
MDX-447	EGFR	Antibody	CROSS-LINKING AGENT	Epidermal growth factor receptor erbB1 cross-linking agent	2	0
AEE-788	KDR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	1
PYROTINIB	ERBB2	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	3	0
ERLOTINIB HYDROCHLORIDE	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	4	2
SKLB1028	ABL1	Small molecule	INHIBITOR	Tyrosine-protein kinase ABL inhibitor	3	0
OSIMERTINIB MESYLATE	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	4	0
TAK-285	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	1	0
MAVELERTINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	2	0
ICOTINIB	EGFR	Small molecule	INHIBITOR	Epidermal growth factor receptor erbB1 inhibitor	3	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-600

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-08223	EPHA5	down-regulates	MAZ	activates	R-600	25	6	Drugs (71) Regulator Drugs (0) Regulon Drugs (71) POZIOTINIB, VARLITINIB, CUDC-101, LAPATINIB DITOSYLATE, DULIGOTUZUMAB, FUTUXIMAB, NAZARTINIB, MP-412, NIMOTUZUMAB, TOMUZOTUXIMAB, ROCILETINIB, CANERTINIB DIHYDROCHLORIDE, NERATINIB MALEATE, MOBOCERTINIB, GEFITINIB, CEP-32496, LAPATINIB, ALMONERTINIB, BRIGATINIB, EPITINIB, SAPITINIB, NERATINIB, BMS-690514, PELITINIB, AC-480, PANITUMUMAB, DACOMITINIB, ABIVERTINIB, KBP5209, TARLOXOTINIB, ABIVERTINIB MALEATE, DEPATUXIZUMAB, ALFLUTINIB, SIMOTINIB, PF-06459988, THELIATINIB, VANDETANIB, ALLITINIB, DEPATUXIZUMAB MAFODOTIN, OLMUTINIB, CLN-081, AZD-3759, OSIMERTINIB, MAB-425, CANERTINIB, BDTX189, AMIVANTAMAB, GC1118, JNJ-26483327, TESEVATINIB, NECITUMUMAB, MATUZUMAB, ZALUTUMUMAB, FALNIDAMOL, ERLOTINIB, AFATINIB DIMALEATE, IMGATUZUMAB, AFATINIB, CETUXIMAB, RINDOPEPIMUT, NAQUOTINIB, OCRIPLASMIN, MDX-447, AEE-788, PYROTINIB, ERLOTINIB HYDROCHLORIDE, SKLB1028, OSIMERTINIB MESYLATE, TAK-285, MAVELERTINIB, ICOTINIB