Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
SPRY4 - sprouty RTK signaling antagonist 4
Function
Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 81848 | ENSG00000187678 | SPRY4 | Q9C004 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1011 | Pr-38 | 1 | 1 | 22 |
| R-1016 | Pr-38 | 1 | 1 | 9 |
| R-1036 | Pr-38 | 1 | 1 | 9 |
| R-1099 | Pr-38 | 1 | 1 | 11 |
| R-1101 | Pr-40 | 1 | 1 | 7 |
| R-1210 | Pr-38 | 1 | 1 | 8 |
| R-1239 | Pr-38 | 1 | 1 | 25 |
| R-1301 | Pr-38 | 1 | 1 | 38 |
| R-1355 | Pr-40 | 1 | 1 | 8 |
| R-1462 | Pr-38 | 1 | 1 | 3 |
| R-1590 | Pr-38 | 1 | 1 | 22 |
| R-1736 | Pr-38 | 1 | 1 | 2 |
| R-1772 | Pr-38 | 1 | 1 | 26 |
| R-1830 | Pr-38 | 1 | 1 | 16 |
| R-1873 | Pr-38 | 1 | 1 | 27 |
| R-1875 | Pr-38 | 1 | 1 | 6 |
| R-1884 | Pr-38 | 1 | 1 | 7 |
| R-1938 | Pr-38 | 1 | 1 | 36 |
| R-1950 | Pr-43 | 1 | 1 | 45 |
| R-1967 | Pr-40 | 1 | 1 | 6 |
| R-2021 | Pr-38 | 1 | 1 | 69 |
| R-2032 | Pr-38 | 1 | 1 | 54 |
| R-2159 | Pr-38 | 1 | 1 | 32 |
| R-2370 | Pr-38 | 1 | 1 | 1 |
| R-2371 | Pr-40 | 1 | 1 | 5 |
| R-2381 | Pr-40 | 1 | 1 | 11 |
| R-2383 | Pr-38 | 1 | 1 | 9 |
| R-2384 | Pr-38 | 1 | 1 | 16 |
| R-2411 | Pr-40 | 1 | 1 | 6 |
| R-2685 | Pr-38 | 1 | 1 | 42 |
| R-2737 | Pr-38 | 1 | 1 | 42 |
| R-2738 | Pr-38 | 1 | 1 | 21 |
| R-2768 | Pr-38 | 1 | 1 | 6 |
| R-2807 | Pr-38 | 1 | 1 | 5 |
| R-2816 | Pr-38 | 1 | 1 | 20 |
| R-2843 | Pr-38 | 1 | 1 | 36 |
| R-2861 | Pr-38 | 1 | 1 | 31 |
| R-2884 | Pr-38 | 1 | 1 | 33 |
| R-2944 | Pr-38 | 1 | 1 | 16 |
| R-2962 | Pr-38 | 1 | 1 | 52 |
| R-3403 | Pr-40 | 1 | 1 | 14 |
| R-462 | Pr-38 | 1 | 1 | 24 |
| R-600 | Pr-40 | 1 | 1 | 1 |
| R-625 | Pr-38 | 1 | 1 | 5 |
| R-650 | Pr-38 | 1 | 1 | 36 |
| R-698 | Pr-38 | 1 | 1 | 26 |
| R-767 | Pr-38 | 1 | 1 | 3 |
| R-871 | Pr-38 | 1 | 1 | 25 |
| R-968 | Pr-38 | 1 | 1 | 22 |