Regulon – gbmMINER Portal

Regulon: R-2588

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
25	1.66046	1	0	Pr-143

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
1495	ENSG00000044115	CTNNA1	E5RGS1
23161	ENSG00000071189	SNX13	A0A087WUZ7
9689	ENSG00000082153	BZW1	Q7L1Q6
334	ENSG00000084234	APLP2	Q06481
3655	ENSG00000091409	ITGA6	P23229
3717	ENSG00000096968	JAK2	O60674
5216	ENSG00000108518	PFN1	P07737
3312	ENSG00000109971	HSPA8	A8K7Q2
50862	ENSG00000110315	RNF141	Q8WVD5
10114	ENSG00000110422	HIPK3	Q9H422
10728	ENSG00000110958	PTGES3	Q15185
55825	ENSG00000115425	PECR	Q9BY49
5052	ENSG00000117450	PRDX1	Q06830
6272	ENSG00000134243	SORT1	Q99523
3936	ENSG00000136167	LCP1	P13796
7099	ENSG00000136869	TLR4	O00206
9180	ENSG00000145623	OSMR	Q99650
1973	ENSG00000161960	EIF4A1	P60842
6565	ENSG00000163406	SLC15A2	Q16348
25932	ENSG00000169504	CLIC4	Q9Y696
4973	ENSG00000173391	OLR1	A0A024RAU0
3766	ENSG00000177807	KCNJ10	P78508
2760	ENSG00000196743	GM2A	P17900
5660	ENSG00000197746	PSAP	P07602
4067	ENSG00000254087	LYN	P07948

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
RUXOLITINIB	JAK1	Small molecule	INHIBITOR	Tyrosine-protein kinase JAK2 inhibitor	4	1
PACRITINIB	FLT3	Small molecule	INHIBITOR	Tyrosine-protein kinase receptor FLT3 inhibitor	3	0
IZENCITINIB	JAK1	Small molecule	INHIBITOR	Janus Kinase (JAK) inhibitor	2	0
TOFACITINIB	JAK1	Small molecule	INHIBITOR	Janus Kinase (JAK) inhibitor	4	0
GANDOTINIB	JAK2	Small molecule	INHIBITOR	Tyrosine-protein kinase JAK2 inhibitor	2	0
DASATINIB	ABL1	Small molecule	INHIBITOR	Platelet-derived growth factor receptor beta inhibitor	4	2
RUXOLITINIB PHOSPHATE	JAK1	Small molecule	INHIBITOR	Tyrosine-protein kinase JAK2 inhibitor	4	0
PEFICITINIB	JAK1	Small molecule	INHIBITOR	Janus Kinase (JAK) inhibitor	3	0
FORIGERIMOD	HSPA8	Protein	INHIBITOR	Heat shock cognate 71 kDa protein inhibitor	3	0
LESTAURTINIB	JAK2	Small molecule	INHIBITOR	Tyrosine-protein kinase JAK2 inhibitor	3	0
AC-430	JAK2	Small molecule	INHIBITOR	Tyrosine-protein kinase JAK2 inhibitor	1	0
BOSUTINIB	ABL1	Small molecule	INHIBITOR	Bcr/Abl fusion protein	4	2
BAFETINIB	LYN	Small molecule	INHIBITOR	Tyrosine-protein kinase ABL inhibitor	2	0
MOMELOTINIB	JAK1	Small molecule	INHIBITOR	Tyrosine-protein kinase JAK2 inhibitor	3	0
NS-018	JAK2	Small molecule	INHIBITOR	Tyrosine-protein kinase JAK2 inhibitor	2	0
BARICITINIB	JAK1	Small molecule	INHIBITOR	Tyrosine-protein kinase JAK2 inhibitor	4	0
ILORASERTIB	PDGFRB	Small molecule	INHIBITOR	Serine/threonine-protein kinase Aurora inhibitor	2	0
BMS-911543	JAK2	Small molecule	INHIBITOR	Tyrosine-protein kinase JAK2 inhibitor	2	0
JNJ-26483327	ERBB2	Small molecule	INHIBITOR	Tyrosine-protein kinase FYN inhibitor	1	0
UPADACITINIB	JAK1	Small molecule	INHIBITOR	Janus Kinase (JAK) inhibitor	4	0
FEDRATINIB HYDROCHLORIDE	JAK2	Small molecule	INHIBITOR	Tyrosine-protein kinase JAK2 inhibitor	4	0
RESATORVID	TLR4	Small molecule	INHIBITOR	Toll-like receptor 4 inhibitor	3	0
XL-228	ABL1	Small molecule	INHIBITOR	Tyrosine-protein kinase ABL inhibitor	1	0
ZOTIRACICLIB	CDK9	Small molecule	INHIBITOR	Cyclin-dependent kinase 9 inhibitor	1	1
TOFACITINIB CITRATE	JAK1	Small molecule	INHIBITOR	Janus Kinase (JAK) inhibitor	4	0
FORIGERIMOD ACETATE	HSPA8	Protein	INHIBITOR	Heat shock cognate 71 kDa protein inhibitor	3	0
GUSACITINIB	SYK	Small molecule	INHIBITOR	Janus Kinase (JAK) inhibitor	2	0
TOLIMIDONE	LYN	Small molecule	POSITIVE ALLOSTERIC MODULATOR	Tyrosine-protein kinase Lyn positive allosteric modulator	2	0
ERITORAN TETRASODIUM	TLR4	Small molecule	ANTAGONIST	Toll-like receptor 4/MD-2 antagonist	3	0
TG100-801	EPHB4	Small molecule	INHIBITOR	SRC inhibitor	2	0
XL-019	JAK2	Small molecule	INHIBITOR	Tyrosine-protein kinase JAK2 inhibitor	1	0
AZD-1480	JAK2	Small molecule	INHIBITOR	Tyrosine-protein kinase JAK2 inhibitor	2	0
DELGOCITINIB	JAK1	Small molecule	INHIBITOR	Janus Kinase (JAK) inhibitor	3	0
ERITORAN	TLR4	Small molecule	ANTAGONIST	Toll-like receptor 4/MD-2 antagonist	3	0
AT-9283	AURKB	Small molecule	INHIBITOR	Tyrosine-protein kinase JAK3 inhibitor	2	0
FEDRATINIB	JAK2	Small molecule	INHIBITOR	Tyrosine-protein kinase JAK2 inhibitor	4	0
ENMD-981693	PDGFRB	Small molecule	INHIBITOR	Platelet-derived growth factor receptor inhibitor	2	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-2588

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs