Regulon

Regulon: R-2421

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
7-2.4362117Pr-120Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
7072 ENSG00000116001 TIA1 P31483
8405 ENSG00000121067 SPOP O43791
10617 ENSG00000124356 STAMBP A0A804HL38
51444 ENSG00000134758 RNF138 Q8WVD3
648 ENSG00000168283 BMI1 P35226
7324 ENSG00000170142 UBE2E1 B7Z306
8493 ENSG00000170836 PPM1D O15297

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-2421

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-00262SPTA1down-regulatesFOXD1activatesR-2421105Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-03436ZNF28down-regulatesFOXD1activatesR-2421102Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-05219C6orf170up-regulatesFOXD1activatesR-2421102Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-18082DLGAP2up-regulatesFOXD1activatesR-2421104Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-22378IDH1up-regulatesFOXD1activatesR-2421108Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-25336PARGup-regulatesFOXD1activatesR-2421102Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-30215TEP1up-regulatesFOXD1activatesR-2421102Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)