Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
IRF7 - interferon regulatory factor 7
Function
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:28342865). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:17574024, PubMed:32972995). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity) (PubMed:11073981, PubMed:12374802, PubMed:15361868, PubMed:17404045).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 3665 | ENSG00000276561 | IRF7 | Q92985 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000276561 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01203 | IRAK3 | down-regulates | IRF7 | activates | R-2476 | 21 | 5 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB |
| CMF-01204 | IRAK3 | down-regulates | IRF7 | activates | R-2492 | 21 | 5 | Drugs (1) |
| CMF-01206 | IRAK3 | down-regulates | IRF7 | activates | R-2477 | 21 | 5 | Drugs (2) |
| CMF-02107 | ABCA4 | up-regulates | IRF7 | activates | R-2479 | 21 | 4 | Drugs (2) |
| CMF-02108 | ABCA4 | up-regulates | IRF7 | activates | R-2491 | 21 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02109 | ABCA4 | up-regulates | IRF7 | activates | R-2492 | 21 | 4 | Drugs (1) |
| CMF-02266 | CHD9 | up-regulates | IRF7 | activates | R-2482 | 21 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02700 | ABCA5 | up-regulates | IRF7 | activates | R-2489 | 21 | 5 | Drugs (2) |
| CMF-02701 | ABCA5 | up-regulates | IRF7 | activates | R-2491 | 21 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02702 | ABCA5 | up-regulates | IRF7 | activates | R-2482 | 21 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02703 | ABCA5 | up-regulates | IRF7 | activates | R-2476 | 21 | 5 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB |
| CMF-02704 | ABCA5 | up-regulates | IRF7 | activates | R-2495 | 21 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02873 | SRRM2 | up-regulates | IRF7 | activates | R-2479 | 21 | 3 | Drugs (2) |
| CMF-02874 | SRRM2 | up-regulates | IRF7 | activates | R-2489 | 21 | 3 | Drugs (2) |
| CMF-02875 | SRRM2 | up-regulates | IRF7 | activates | R-2495 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03241 | OBSCN | down-regulates | IRF7 | activates | R-2495 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03328 | C12orf63 | up-regulates | IRF7 | activates | R-2479 | 21 | 3 | Drugs (2) |
| CMF-03329 | C12orf63 | up-regulates | IRF7 | activates | R-2491 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03330 | C12orf63 | up-regulates | IRF7 | activates | R-2495 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04910 | ABCC5 | down-regulates | IRF7 | activates | R-2479 | 21 | 9 | Drugs (2) |
| CMF-04911 | ABCC5 | down-regulates | IRF7 | activates | R-2491 | 21 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04912 | ABCC5 | down-regulates | IRF7 | activates | R-2482 | 21 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04913 | ABCC5 | down-regulates | IRF7 | activates | R-2486 | 21 | 9 | Drugs (1) |
| CMF-04914 | ABCC5 | down-regulates | IRF7 | activates | R-2493 | 21 | 9 | Drugs (1) |
| CMF-04915 | ABCC5 | down-regulates | IRF7 | activates | R-2475 | 21 | 9 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB |
| CMF-04916 | ABCC5 | down-regulates | IRF7 | activates | R-2492 | 21 | 9 | Drugs (1) |
| CMF-04917 | ABCC5 | down-regulates | IRF7 | activates | R-2478 | 21 | 9 | Drugs (2) |
| CMF-04918 | ABCC5 | down-regulates | IRF7 | activates | R-2481 | 21 | 9 | Drugs (1) |
| CMF-05633 | ITGB7 | up-regulates | IRF7 | activates | R-2479 | 21 | 2 | Drugs (2) |
| CMF-05634 | ITGB7 | up-regulates | IRF7 | activates | R-2476 | 21 | 2 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB |
| CMF-05896 | MKRN3 | down-regulates | IRF7 | activates | R-2489 | 21 | 2 | Drugs (2) |
| CMF-05897 | MKRN3 | down-regulates | IRF7 | activates | R-2495 | 21 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06784 | ATRX | down-regulates | IRF7 | activates | R-2483 | 21 | 19 | Drugs (4) |
| CMF-06785 | ATRX | down-regulates | IRF7 | activates | R-2479 | 21 | 19 | Drugs (2) |
| CMF-06787 | ATRX | down-regulates | IRF7 | activates | R-2489 | 21 | 19 | Drugs (2) |
| CMF-06788 | ATRX | down-regulates | IRF7 | activates | R-2491 | 21 | 19 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06789 | ATRX | down-regulates | IRF7 | activates | R-2482 | 21 | 19 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06790 | ATRX | down-regulates | IRF7 | activates | R-2486 | 21 | 19 | Drugs (1) |
| CMF-06791 | ATRX | down-regulates | IRF7 | activates | R-2476 | 21 | 19 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB |
| CMF-06792 | ATRX | down-regulates | IRF7 | activates | R-2493 | 21 | 19 | Drugs (1) |
| CMF-06793 | ATRX | down-regulates | IRF7 | activates | R-2480 | 21 | 19 | Drugs (21) Regulator Drugs (0)Regulon Drugs (21)TRELAGLIPTIN SUCCINATE, VILDAGLIPTIN, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, ENIBARCIMAB, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-06795 | ATRX | down-regulates | IRF7 | activates | R-2475 | 21 | 19 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB |
| CMF-06796 | ATRX | down-regulates | IRF7 | activates | R-2492 | 21 | 19 | Drugs (1) |
| CMF-06797 | ATRX | down-regulates | IRF7 | activates | R-2484 | 21 | 19 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06798 | ATRX | down-regulates | IRF7 | activates | R-2478 | 21 | 19 | Drugs (2) |
| CMF-06800 | ATRX | down-regulates | IRF7 | activates | R-2477 | 21 | 19 | Drugs (2) |
| CMF-06801 | ATRX | down-regulates | IRF7 | activates | R-2481 | 21 | 19 | Drugs (1) |
| CMF-07512 | OR4N4 | down-regulates | IRF7 | activates | R-2495 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08024 | ATP10B | down-regulates | IRF7 | activates | R-2491 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08170 | TESK1 | down-regulates | IRF7 | activates | R-2495 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08336 | AFM | down-regulates | IRF7 | activates | R-2491 | 21 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08337 | AFM | down-regulates | IRF7 | activates | R-2476 | 21 | 2 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB |
| CMF-09041 | PSD4 | down-regulates | IRF7 | activates | R-2495 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09069 | FLT1 | down-regulates | IRF7 | activates | R-2491 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09070 | FLT1 | down-regulates | IRF7 | activates | R-2475 | 21 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB |
| CMF-09071 | FLT1 | down-regulates | IRF7 | activates | R-2481 | 21 | 3 | Drugs (1) |
| CMF-10116 | PCDHGA8 | down-regulates | IRF7 | activates | R-2475 | 21 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB |
| CMF-11167 | DGKD | down-regulates | IRF7 | activates | R-2482 | 21 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11168 | DGKD | down-regulates | IRF7 | activates | R-2486 | 21 | 4 | Drugs (1) |
| CMF-11170 | DGKD | down-regulates | IRF7 | activates | R-2495 | 21 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11231 | TJP3 | down-regulates | IRF7 | activates | R-2495 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12989 | UGT3A2 | down-regulates | IRF7 | activates | R-2495 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-14690 | PIGR | up-regulates | IRF7 | activates | R-2489 | 21 | 1 | Drugs (2) |
| CMF-15017 | TG | down-regulates | IRF7 | activates | R-2489 | 21 | 2 | Drugs (2) |
| CMF-15018 | TG | down-regulates | IRF7 | activates | R-2476 | 21 | 2 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB |
| CMF-15785 | GRM3 | up-regulates | IRF7 | activates | R-2479 | 21 | 7 | Drugs (2) |
| CMF-15787 | GRM3 | up-regulates | IRF7 | activates | R-2489 | 21 | 7 | Drugs (2) |
| CMF-15788 | GRM3 | up-regulates | IRF7 | activates | R-2491 | 21 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15789 | GRM3 | up-regulates | IRF7 | activates | R-2486 | 21 | 7 | Drugs (1) |
| CMF-15790 | GRM3 | up-regulates | IRF7 | activates | R-2475 | 21 | 7 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB |
| CMF-15791 | GRM3 | up-regulates | IRF7 | activates | R-2478 | 21 | 7 | Drugs (2) |
| CMF-15944 | KCNB2 | up-regulates | IRF7 | activates | R-2482 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15945 | KCNB2 | up-regulates | IRF7 | activates | R-2476 | 21 | 3 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB |
| CMF-15946 | KCNB2 | up-regulates | IRF7 | activates | R-2477 | 21 | 3 | Drugs (2) |
| CMF-16396 | SUSD5 | up-regulates | IRF7 | activates | R-2489 | 21 | 12 | Drugs (2) |
| CMF-16397 | SUSD5 | up-regulates | IRF7 | activates | R-2491 | 21 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16398 | SUSD5 | up-regulates | IRF7 | activates | R-2486 | 21 | 12 | Drugs (1) |
| CMF-16399 | SUSD5 | up-regulates | IRF7 | activates | R-2485 | 21 | 12 | Drugs (2) |
| CMF-16400 | SUSD5 | up-regulates | IRF7 | activates | R-2476 | 21 | 12 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB |
| CMF-16402 | SUSD5 | up-regulates | IRF7 | activates | R-2492 | 21 | 12 | Drugs (1) |
| CMF-16403 | SUSD5 | up-regulates | IRF7 | activates | R-2484 | 21 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16404 | SUSD5 | up-regulates | IRF7 | activates | R-2478 | 21 | 12 | Drugs (2) |
| CMF-16406 | SUSD5 | up-regulates | IRF7 | activates | R-2495 | 21 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17084 | A2BP1 | down-regulates | IRF7 | activates | R-2489 | 21 | 2 | Drugs (2) |
| CMF-17085 | A2BP1 | down-regulates | IRF7 | activates | R-2475 | 21 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB |
| CMF-17522 | CNTNAP3 | up-regulates | IRF7 | activates | R-2489 | 21 | 5 | Drugs (2) |
| CMF-17523 | CNTNAP3 | up-regulates | IRF7 | activates | R-2482 | 21 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17524 | CNTNAP3 | up-regulates | IRF7 | activates | R-2481 | 21 | 5 | Drugs (1) |
| CMF-17525 | CNTNAP3 | up-regulates | IRF7 | activates | R-2495 | 21 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18148 | NWD1 | up-regulates | IRF7 | activates | R-2489 | 21 | 2 | Drugs (2) |
| CMF-18149 | NWD1 | up-regulates | IRF7 | activates | R-2491 | 21 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18699 | MPP7 | down-regulates | IRF7 | activates | R-2479 | 21 | 6 | Drugs (2) |
| CMF-18700 | MPP7 | down-regulates | IRF7 | activates | R-2486 | 21 | 6 | Drugs (1) |
| CMF-18702 | MPP7 | down-regulates | IRF7 | activates | R-2475 | 21 | 6 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB |
| CMF-18703 | MPP7 | down-regulates | IRF7 | activates | R-2484 | 21 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18704 | MPP7 | down-regulates | IRF7 | activates | R-2478 | 21 | 6 | Drugs (2) |
| CMF-18907 | TEAD1 | down-regulates | IRF7 | activates | R-2491 | 21 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18908 | TEAD1 | down-regulates | IRF7 | activates | R-2486 | 21 | 4 | Drugs (1) |
| CMF-18910 | TEAD1 | down-regulates | IRF7 | activates | R-2495 | 21 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-19611 | BRCA1 | down-regulates | IRF7 | activates | R-2489 | 21 | 2 | Drugs (2) |
| CMF-20707 | ALPK1 | up-regulates | IRF7 | activates | R-2493 | 21 | 1 | Drugs (1) |
| CMF-20893 | CD3EAP | down-regulates | IRF7 | activates | R-2491 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21620 | MUC17 | up-regulates | IRF7 | activates | R-2483 | 21 | 12 | Drugs (4) |
| CMF-21621 | MUC17 | up-regulates | IRF7 | activates | R-2489 | 21 | 12 | Drugs (2) |
| CMF-21622 | MUC17 | up-regulates | IRF7 | activates | R-2491 | 21 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21623 | MUC17 | up-regulates | IRF7 | activates | R-2482 | 21 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21624 | MUC17 | up-regulates | IRF7 | activates | R-2485 | 21 | 12 | Drugs (2) |
| CMF-21625 | MUC17 | up-regulates | IRF7 | activates | R-2476 | 21 | 12 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB |
| CMF-21626 | MUC17 | up-regulates | IRF7 | activates | R-2493 | 21 | 12 | Drugs (1) |
| CMF-21627 | MUC17 | up-regulates | IRF7 | activates | R-2484 | 21 | 12 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21628 | MUC17 | up-regulates | IRF7 | activates | R-2478 | 21 | 12 | Drugs (2) |
| CMF-21629 | MUC17 | up-regulates | IRF7 | activates | R-2477 | 21 | 12 | Drugs (2) |
| CMF-21630 | MUC17 | up-regulates | IRF7 | activates | R-2481 | 21 | 12 | Drugs (1) |
| CMF-22018 | MOCS3 | up-regulates | IRF7 | activates | R-2489 | 21 | 3 | Drugs (2) |
| CMF-22019 | MOCS3 | up-regulates | IRF7 | activates | R-2482 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22423 | IDH1 | down-regulates | IRF7 | activates | R-2483 | 21 | 20 | Drugs (4) |
| CMF-22424 | IDH1 | down-regulates | IRF7 | activates | R-2479 | 21 | 20 | Drugs (2) |
| CMF-22426 | IDH1 | down-regulates | IRF7 | activates | R-2489 | 21 | 20 | Drugs (2) |
| CMF-22427 | IDH1 | down-regulates | IRF7 | activates | R-2491 | 21 | 20 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22428 | IDH1 | down-regulates | IRF7 | activates | R-2482 | 21 | 20 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22429 | IDH1 | down-regulates | IRF7 | activates | R-2486 | 21 | 20 | Drugs (1) |
| CMF-22430 | IDH1 | down-regulates | IRF7 | activates | R-2485 | 21 | 20 | Drugs (2) |
| CMF-22431 | IDH1 | down-regulates | IRF7 | activates | R-2476 | 21 | 20 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB |
| CMF-22432 | IDH1 | down-regulates | IRF7 | activates | R-2493 | 21 | 20 | Drugs (1) |
| CMF-22433 | IDH1 | down-regulates | IRF7 | activates | R-2480 | 21 | 20 | Drugs (21) Regulator Drugs (0)Regulon Drugs (21)TRELAGLIPTIN SUCCINATE, VILDAGLIPTIN, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, ENIBARCIMAB, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-22435 | IDH1 | down-regulates | IRF7 | activates | R-2475 | 21 | 20 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB |
| CMF-22436 | IDH1 | down-regulates | IRF7 | activates | R-2492 | 21 | 20 | Drugs (1) |
| CMF-22437 | IDH1 | down-regulates | IRF7 | activates | R-2484 | 21 | 20 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22438 | IDH1 | down-regulates | IRF7 | activates | R-2478 | 21 | 20 | Drugs (2) |
| CMF-22440 | IDH1 | down-regulates | IRF7 | activates | R-2477 | 21 | 20 | Drugs (2) |
| CMF-22441 | IDH1 | down-regulates | IRF7 | activates | R-2481 | 21 | 20 | Drugs (1) |
| CMF-23066 | HLTF | up-regulates | IRF7 | activates | R-2489 | 21 | 1 | Drugs (2) |
| CMF-23118 | CTAGE1 | up-regulates | IRF7 | activates | R-2493 | 21 | 1 | Drugs (1) |
| CMF-23439 | SRCAP | down-regulates | IRF7 | activates | R-2489 | 21 | 2 | Drugs (2) |
| CMF-24736 | RABGEF1 | up-regulates | IRF7 | activates | R-2495 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27673 | FAM83H | down-regulates | IRF7 | activates | R-2483 | 21 | 6 | Drugs (4) |
| CMF-27674 | FAM83H | down-regulates | IRF7 | activates | R-2489 | 21 | 6 | Drugs (2) |
| CMF-27675 | FAM83H | down-regulates | IRF7 | activates | R-2482 | 21 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27676 | FAM83H | down-regulates | IRF7 | activates | R-2476 | 21 | 6 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB |
| CMF-27677 | FAM83H | down-regulates | IRF7 | activates | R-2478 | 21 | 6 | Drugs (2) |
| CMF-27742 | C21orf29 | down-regulates | IRF7 | activates | R-2475 | 21 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB |
| CMF-28354 | LAMB1 | up-regulates | IRF7 | activates | R-2479 | 21 | 3 | Drugs (2) |
| CMF-28355 | LAMB1 | up-regulates | IRF7 | activates | R-2491 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28356 | LAMB1 | up-regulates | IRF7 | activates | R-2495 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28619 | ARHGAP28 | up-regulates | IRF7 | activates | R-2486 | 21 | 1 | Drugs (1) |
| CMF-28724 | POF1B | up-regulates | IRF7 | activates | R-2479 | 21 | 3 | Drugs (2) |
| CMF-28726 | POF1B | up-regulates | IRF7 | activates | R-2495 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29259 | NEU2 | down-regulates | IRF7 | activates | R-2475 | 21 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)DASATINIB, VANDETANIB, TESEVATINIB, JI-101, TG100-801, REGORAFENIB |
| CMF-29260 | NEU2 | down-regulates | IRF7 | activates | R-2492 | 21 | 2 | Drugs (1) |
| CMF-29412 | EPHA8 | up-regulates | IRF7 | activates | R-2479 | 21 | 6 | Drugs (2) |
| CMF-29414 | EPHA8 | up-regulates | IRF7 | activates | R-2489 | 21 | 6 | Drugs (2) |
| CMF-29415 | EPHA8 | up-regulates | IRF7 | activates | R-2491 | 21 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29416 | EPHA8 | up-regulates | IRF7 | activates | R-2486 | 21 | 6 | Drugs (1) |
| CMF-29417 | EPHA8 | up-regulates | IRF7 | activates | R-2495 | 21 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29455 | OR2T3 | down-regulates | IRF7 | activates | R-2479 | 21 | 1 | Drugs (2) |
| CMF-30000 | CYP4F3 | down-regulates | IRF7 | activates | R-2495 | 21 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30243 | SCN7A | up-regulates | IRF7 | activates | R-2493 | 21 | 1 | Drugs (1) |
| CMF-30773 | ZDBF2 | down-regulates | IRF7 | activates | R-2489 | 21 | 3 | Drugs (2) |
| CMF-30774 | ZDBF2 | down-regulates | IRF7 | activates | R-2491 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30775 | ZDBF2 | down-regulates | IRF7 | activates | R-2495 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-31448 | SIGNALING_EVENTS_MEDIATED_BY_TCPTP | up-regulates | IRF7 | activates | R-2479 | 21 | 5 | Drugs (2) |
| CMF-31449 | SIGNALING_EVENTS_MEDIATED_BY_TCPTP | up-regulates | IRF7 | activates | R-2482 | 21 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-31450 | SIGNALING_EVENTS_MEDIATED_BY_TCPTP | up-regulates | IRF7 | activates | R-2485 | 21 | 5 | Drugs (2) |
| CMF-31451 | SIGNALING_EVENTS_MEDIATED_BY_TCPTP | up-regulates | IRF7 | activates | R-2476 | 21 | 5 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB |
| CMF-31452 | SIGNALING_EVENTS_MEDIATED_BY_TCPTP | up-regulates | IRF7 | activates | R-2484 | 21 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-31747 | PDGFR_ALPHA_SIGNALING_PATHWAY | up-regulates | IRF7 | activates | R-2491 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-31748 | PDGFR_ALPHA_SIGNALING_PATHWAY | up-regulates | IRF7 | activates | R-2482 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-31749 | PDGFR_ALPHA_SIGNALING_PATHWAY | up-regulates | IRF7 | activates | R-2495 | 21 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-33714 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF7 | activates | R-2479 | 21 | 7 | Drugs (2) |
| CMF-33715 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF7 | activates | R-2489 | 21 | 7 | Drugs (2) |
| CMF-33716 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF7 | activates | R-2491 | 21 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-33717 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF7 | activates | R-2482 | 21 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-33718 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF7 | activates | R-2485 | 21 | 7 | Drugs (2) |
| CMF-33719 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF7 | activates | R-2476 | 21 | 7 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB |
| CMF-33720 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF7 | activates | R-2495 | 21 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |