Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
MAFF - MAF bZIP transcription factor F
Function
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:8932385, PubMed:16549056). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 23764 | ENSG00000185022 | MAFF | Q9ULX9 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000185022 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00759 | DNAH5 | up-regulates | MAFF | activates | R-3371 | 2 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)FIBOFLAPON SODIUM, AME-133V, EFALIZUMAB, LIFITEGRAST, VELIFLAPON, FIBOFLAPON |
| CMF-00760 | DNAH5 | up-regulates | MAFF | activates | R-3370 | 2 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01637 | MCM6 | up-regulates | MAFF | activates | R-3371 | 2 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)FIBOFLAPON SODIUM, AME-133V, EFALIZUMAB, LIFITEGRAST, VELIFLAPON, FIBOFLAPON |
| CMF-01638 | MCM6 | up-regulates | MAFF | activates | R-3370 | 2 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-05212 | ZFYVE26 | down-regulates | MAFF | activates | R-3370 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07177 | ATRX | down-regulates | MAFF | activates | R-3371 | 2 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)FIBOFLAPON SODIUM, AME-133V, EFALIZUMAB, LIFITEGRAST, VELIFLAPON, FIBOFLAPON |
| CMF-07178 | ATRX | down-regulates | MAFF | activates | R-3370 | 2 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07863 | TNK2 | down-regulates | MAFF | activates | R-3371 | 2 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)FIBOFLAPON SODIUM, AME-133V, EFALIZUMAB, LIFITEGRAST, VELIFLAPON, FIBOFLAPON |
| CMF-07864 | TNK2 | down-regulates | MAFF | activates | R-3370 | 2 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13878 | ADAMTS8 | down-regulates | MAFF | activates | R-3371 | 2 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)FIBOFLAPON SODIUM, AME-133V, EFALIZUMAB, LIFITEGRAST, VELIFLAPON, FIBOFLAPON |
| CMF-13879 | ADAMTS8 | down-regulates | MAFF | activates | R-3370 | 2 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15962 | KCNB2 | up-regulates | MAFF | activates | R-3371 | 2 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)FIBOFLAPON SODIUM, AME-133V, EFALIZUMAB, LIFITEGRAST, VELIFLAPON, FIBOFLAPON |
| CMF-15963 | KCNB2 | up-regulates | MAFF | activates | R-3370 | 2 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22991 | IDH1 | down-regulates | MAFF | activates | R-3370 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24220 | OR4K5 | down-regulates | MAFF | activates | R-3370 | 2 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27565 | JPH2 | up-regulates | MAFF | activates | R-3371 | 2 | 1 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)FIBOFLAPON SODIUM, AME-133V, EFALIZUMAB, LIFITEGRAST, VELIFLAPON, FIBOFLAPON |