Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
MSX1 - msh homeobox 1
Function
Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 4487 | ENSG00000163132 | MSX1 | P28360 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000163132 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01733 | ARHGAP5 | up-regulates | MSX1 | activates | R-2824 | 12 | 2 | Drugs (2) |
| CMF-02168 | ABCA4 | up-regulates | MSX1 | activates | R-2817 | 12 | 2 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)AMG-780, MEDI-3617, F16SIP 131I, TREBANANIB, F16IL2, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-04445 | ADAM6 | up-regulates | MSX1 | activates | R-2819 | 12 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-05466 | KIAA1549 | up-regulates | MSX1 | activates | R-2819 | 12 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06008 | C4orf35 | up-regulates | MSX1 | activates | R-2821 | 12 | 2 | Drugs (1) |
| CMF-08005 | OR5D13 | up-regulates | MSX1 | activates | R-2821 | 12 | 2 | Drugs (1) |
| CMF-08006 | OR5D13 | up-regulates | MSX1 | activates | R-2825 | 12 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08200 | TPO | up-regulates | MSX1 | activates | R-2820 | 12 | 3 | Drugs (13) Regulator Drugs (0)Regulon Drugs (13)TRILACICLIB, RIBOCICLIB, PALBOCICLIB, ABEMACICLIB, PHA-793887, AZD-5438, RIBOCICLIB SUCCINATE, TRILACICLIB DIHYDROCHLORIDE, UCN-01, ALVOCIDIB, RONICICLIB, AT-7519, ABITUZUMAB |
| CMF-08202 | TPO | up-regulates | MSX1 | activates | R-2821 | 12 | 3 | Drugs (1) |
| CMF-08417 | ADCY2 | up-regulates | MSX1 | activates | R-2824 | 12 | 1 | Drugs (2) |
| CMF-10372 | FGG | up-regulates | MSX1 | activates | R-2819 | 12 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13625 | FMN1 | up-regulates | MSX1 | activates | R-2820 | 12 | 4 | Drugs (13) Regulator Drugs (0)Regulon Drugs (13)TRILACICLIB, RIBOCICLIB, PALBOCICLIB, ABEMACICLIB, PHA-793887, AZD-5438, RIBOCICLIB SUCCINATE, TRILACICLIB DIHYDROCHLORIDE, UCN-01, ALVOCIDIB, RONICICLIB, AT-7519, ABITUZUMAB |
| CMF-13627 | FMN1 | up-regulates | MSX1 | activates | R-2817 | 12 | 4 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)AMG-780, MEDI-3617, F16SIP 131I, TREBANANIB, F16IL2, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-13628 | FMN1 | up-regulates | MSX1 | activates | R-2824 | 12 | 4 | Drugs (2) |
| CMF-14108 | DENND2A | up-regulates | MSX1 | activates | R-2817 | 12 | 1 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)AMG-780, MEDI-3617, F16SIP 131I, TREBANANIB, F16IL2, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-14951 | SDHAP3 | up-regulates | MSX1 | activates | R-2817 | 12 | 1 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)AMG-780, MEDI-3617, F16SIP 131I, TREBANANIB, F16IL2, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-16964 | TIE1 | up-regulates | MSX1 | activates | R-2816 | 12 | 2 | Drugs (2) |
| CMF-17190 | CREB3L3 | down-regulates | MSX1 | activates | R-2824 | 12 | 2 | Drugs (2) |
| CMF-17335 | SYNJ2 | up-regulates | MSX1 | activates | R-2821 | 12 | 2 | Drugs (1) |
| CMF-18257 | CDH19 | up-regulates | MSX1 | activates | R-2817 | 12 | 1 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)AMG-780, MEDI-3617, F16SIP 131I, TREBANANIB, F16IL2, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-18356 | SHB | up-regulates | MSX1 | activates | R-2820 | 12 | 1 | Drugs (13) Regulator Drugs (0)Regulon Drugs (13)TRILACICLIB, RIBOCICLIB, PALBOCICLIB, ABEMACICLIB, PHA-793887, AZD-5438, RIBOCICLIB SUCCINATE, TRILACICLIB DIHYDROCHLORIDE, UCN-01, ALVOCIDIB, RONICICLIB, AT-7519, ABITUZUMAB |
| CMF-18419 | FANCM | down-regulates | MSX1 | activates | R-2825 | 12 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18425 | FILIP1 | down-regulates | MSX1 | activates | R-2819 | 12 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18763 | LY75 | down-regulates | MSX1 | activates | R-2819 | 12 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-19827 | OR6C75 | up-regulates | MSX1 | activates | R-2819 | 12 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-19828 | OR6C75 | up-regulates | MSX1 | activates | R-2824 | 12 | 2 | Drugs (2) |
| CMF-21190 | ATM | up-regulates | MSX1 | activates | R-2817 | 12 | 2 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)AMG-780, MEDI-3617, F16SIP 131I, TREBANANIB, F16IL2, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-21191 | ATM | up-regulates | MSX1 | activates | R-2825 | 12 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24366 | SMCHD1 | up-regulates | MSX1 | activates | R-2817 | 12 | 6 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)AMG-780, MEDI-3617, F16SIP 131I, TREBANANIB, F16IL2, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-24368 | SMCHD1 | up-regulates | MSX1 | activates | R-2821 | 12 | 6 | Drugs (1) |
| CMF-24369 | SMCHD1 | up-regulates | MSX1 | activates | R-2824 | 12 | 6 | Drugs (2) |
| CMF-25001 | NLRP1 | up-regulates | MSX1 | activates | R-2817 | 12 | 5 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)AMG-780, MEDI-3617, F16SIP 131I, TREBANANIB, F16IL2, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-25002 | NLRP1 | up-regulates | MSX1 | activates | R-2821 | 12 | 5 | Drugs (1) |
| CMF-25205 | ZNF534 | up-regulates | MSX1 | activates | R-2824 | 12 | 1 | Drugs (2) |
| CMF-32380 | STABILIZATION | up-regulates | MSX1 | activates | R-2817 | 12 | 3 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)AMG-780, MEDI-3617, F16SIP 131I, TREBANANIB, F16IL2, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-32382 | STABILIZATION | up-regulates | MSX1 | activates | R-2824 | 12 | 3 | Drugs (2) |
| CMF-31270 | SHP2_SIGNALING | up-regulates | MSX1 | activates | R-2820 | 12 | 2 | Drugs (13) Regulator Drugs (0)Regulon Drugs (13)TRILACICLIB, RIBOCICLIB, PALBOCICLIB, ABEMACICLIB, PHA-793887, AZD-5438, RIBOCICLIB SUCCINATE, TRILACICLIB DIHYDROCHLORIDE, UCN-01, ALVOCIDIB, RONICICLIB, AT-7519, ABITUZUMAB |
| CMF-31723 | THROMBOXANE_A2_RECEPTOR_SIGNALING | up-regulates | MSX1 | activates | R-2817 | 12 | 3 | Drugs (10) Regulator Drugs (0)Regulon Drugs (10)AMG-780, MEDI-3617, F16SIP 131I, TREBANANIB, F16IL2, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-31725 | THROMBOXANE_A2_RECEPTOR_SIGNALING | up-regulates | MSX1 | activates | R-2824 | 12 | 3 | Drugs (2) |