Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation ZNF534_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-25198 | ZNF534 | up-regulates | MEOX2 | activates | R-2196 | 14 | 1 | Drugs (1) |
| CMF-25201 | ZNF534 | up-regulates | IRF3 | activates | R-2441 | 25 | 3 | Drugs (2) |
| CMF-25203 | ZNF534 | up-regulates | IRF3 | activates | R-2427 | 25 | 3 | Drugs (1) |
| CMF-25204 | ZNF534 | down-regulates | MNX1 | represses | R-2260 | 4 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25205 | ZNF534 | up-regulates | MSX1 | activates | R-2824 | 12 | 1 | Drugs (2) |
| CMF-41935 | ZNF534 | down-regulates | hsa-mir-328 | represses | R-152 | 27 | 6 | Drugs (1) |
| CMF-41936 | ZNF534 | down-regulates | hsa-mir-328 | represses | R-2441 | 27 | 6 | Drugs (2) |
| CMF-41937 | ZNF534 | down-regulates | hsa-mir-328 | represses | R-1047 | 27 | 6 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, TOSEDOSTAT, RIBAVIRIN |
| CMF-41938 | ZNF534 | down-regulates | hsa-mir-328 | represses | R-1734 | 27 | 6 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-41939 | ZNF534 | down-regulates | hsa-mir-328 | represses | R-3789 | 27 | 6 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-41940 | ZNF534 | down-regulates | hsa-mir-328 | represses | R-2043 | 27 | 6 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-41941 | ZNF534 | down-regulates | hsa-mir-153 | represses | R-152 | 62 | 6 | Drugs (1) |
| CMF-41942 | ZNF534 | down-regulates | hsa-mir-153 | represses | R-2326 | 62 | 6 | Drugs (1) |
| CMF-41943 | ZNF534 | down-regulates | hsa-mir-153 | represses | R-2441 | 62 | 6 | Drugs (2) |
| CMF-41944 | ZNF534 | down-regulates | hsa-mir-153 | represses | R-1047 | 62 | 6 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, TOSEDOSTAT, RIBAVIRIN |
| CMF-41945 | ZNF534 | down-regulates | hsa-mir-153 | represses | R-2008 | 62 | 6 | Drugs (1) |
| CMF-41946 | ZNF534 | down-regulates | hsa-mir-153 | represses | R-2043 | 62 | 6 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, RIBAVIRIN |
| CMF-41947 | ZNF534 | down-regulates | hsa-mir-326 | represses | R-2196 | 16 | 6 | Drugs (1) |
| CMF-41948 | ZNF534 | down-regulates | hsa-mir-326 | represses | R-218 | 16 | 6 | Drugs (3) |
| CMF-41949 | ZNF534 | down-regulates | hsa-mir-326 | represses | R-2260 | 16 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-41950 | ZNF534 | down-regulates | hsa-mir-326 | represses | R-2892 | 16 | 6 | Drugs (3) |
| CMF-41951 | ZNF534 | down-regulates | hsa-mir-326 | represses | R-3643 | 16 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-41952 | ZNF534 | down-regulates | hsa-mir-326 | represses | R-2006 | 16 | 6 | Drugs (3) |
| CMF-41953 | ZNF534 | down-regulates | hsa-mir-577 | represses | R-2196 | 65 | 9 | Drugs (1) |
| CMF-41954 | ZNF534 | down-regulates | hsa-mir-577 | represses | R-152 | 65 | 9 | Drugs (1) |
| CMF-41955 | ZNF534 | down-regulates | hsa-mir-577 | represses | R-166 | 65 | 9 | Drugs (1) |
| CMF-41956 | ZNF534 | down-regulates | hsa-mir-577 | represses | R-218 | 65 | 9 | Drugs (3) |
| CMF-41957 | ZNF534 | down-regulates | hsa-mir-577 | represses | R-2260 | 65 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-41958 | ZNF534 | down-regulates | hsa-mir-577 | represses | R-2441 | 65 | 9 | Drugs (2) |
| CMF-41959 | ZNF534 | down-regulates | hsa-mir-577 | represses | R-2892 | 65 | 9 | Drugs (3) |
| CMF-41960 | ZNF534 | down-regulates | hsa-mir-577 | represses | R-3643 | 65 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-41961 | ZNF534 | down-regulates | hsa-mir-577 | represses | R-2006 | 65 | 9 | Drugs (3) |