Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

SOX3 - SRY-box transcription factor 3

Function

Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity).

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
6658 ENSG00000134595 SOX3 P41225

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000134595 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-00213PCLOdown-regulatesSOX3repressesR-173261Drugs (59)
CMF-00755DNAH5down-regulatesSOX3repressesR-173061Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-01194SKAP2down-regulatesSOX3repressesR-172861Drugs (10)
CMF-01243TLR2up-regulatesSOX3repressesR-173161Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-02914CDK13down-regulatesSOX3repressesR-173261Drugs (59)
CMF-03237FAT4down-regulatesSOX3repressesR-173261Drugs (59)
CMF-04336RBPJLdown-regulatesSOX3repressesR-173265Drugs (59)
CMF-04337RBPJLdown-regulatesSOX3repressesR-173065Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-04338RBPJLdown-regulatesSOX3repressesR-173165Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-04967ABCC5up-regulatesSOX3repressesR-173061Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-07136ATRXup-regulatesSOX3repressesR-173265Drugs (59)
CMF-07137ATRXup-regulatesSOX3repressesR-173065Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-07138ATRXup-regulatesSOX3repressesR-173165Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-07139ATRXup-regulatesSOX3repressesR-172865Drugs (10)
CMF-09644OR9G9down-regulatesSOX3repressesR-173261Drugs (59)
CMF-15467DSEdown-regulatesSOX3repressesR-173263Drugs (59)
CMF-15468DSEdown-regulatesSOX3repressesR-173063Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20615ADCY1down-regulatesSOX3repressesR-173063Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20616ADCY1down-regulatesSOX3repressesR-173163Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-20691CYP4B1down-regulatesSOX3repressesR-173262Drugs (59)
CMF-20692CYP4B1down-regulatesSOX3repressesR-172862Drugs (10)
CMF-21719MUC17down-regulatesSOX3repressesR-173265Drugs (59)
CMF-21720MUC17down-regulatesSOX3repressesR-173065Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-21721MUC17down-regulatesSOX3repressesR-173165Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-21722MUC17down-regulatesSOX3repressesR-172865Drugs (10)
CMF-21921PRAMEdown-regulatesSOX3repressesR-172861Drugs (10)
CMF-22927IDH1up-regulatesSOX3repressesR-173265Drugs (59)
CMF-22928IDH1up-regulatesSOX3repressesR-173065Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-22929IDH1up-regulatesSOX3repressesR-173165Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-22930IDH1up-regulatesSOX3repressesR-172865Drugs (10)
CMF-23287RNF17down-regulatesSOX3repressesR-173261Drugs (59)
CMF-24068TP53up-regulatesSOX3repressesR-173265Drugs (59)
CMF-24069TP53up-regulatesSOX3repressesR-173065Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-24070TP53up-regulatesSOX3repressesR-173165Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-24071TP53up-regulatesSOX3repressesR-172865Drugs (10)
CMF-26511EGFRdown-regulatesSOX3repressesR-173261Drugs (59)
CMF-26652C5AR1down-regulatesSOX3repressesR-173261Drugs (59)
CMF-27353CHD5down-regulatesSOX3repressesR-173262Drugs (59)
CMF-27354CHD5down-regulatesSOX3repressesR-173062Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-27560CXorf57up-regulatesSOX3repressesR-173061Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-27656ANKRD36down-regulatesSOX3repressesR-173064Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-27657ANKRD36down-regulatesSOX3repressesR-173164Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BERMEKIMAB, LUTIKIZUMAB

CMF-27658ANKRD36down-regulatesSOX3repressesR-172864Drugs (10)
CMF-30761POLRMTdown-regulatesSOX3repressesR-172861Drugs (10)
CMF-31756PDGFR_ALPHA_SIGNALING_PATHWAYdown-regulatesSOX3repressesR-173261Drugs (59)