Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
DR1 - down-regulator of transcription 1
Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 1810 | ENSG00000117505 | DR1 | Q01658 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000117505 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-04794 | SLC6A3 | down-regulates | DR1 | activates | R-2982 | 8 | 4 | Drugs (3) Regulator Drugs (0)Regulon Drugs (3)DAVANAT, CINTREDEKIN BESUDOTOX, RECOMBINANT HUMAN INTERLEUKIN-15 |
| CMF-05453 | KIAA1549 | up-regulates | DR1 | activates | R-2982 | 8 | 1 | Drugs (3) Regulator Drugs (0)Regulon Drugs (3)DAVANAT, CINTREDEKIN BESUDOTOX, RECOMBINANT HUMAN INTERLEUKIN-15 |
| CMF-09202 | TANC2 | up-regulates | DR1 | activates | R-2982 | 8 | 2 | Drugs (3) Regulator Drugs (0)Regulon Drugs (3)DAVANAT, CINTREDEKIN BESUDOTOX, RECOMBINANT HUMAN INTERLEUKIN-15 |
| CMF-12797 | HOXA6 | down-regulates | DR1 | activates | R-2982 | 8 | 3 | Drugs (3) Regulator Drugs (0)Regulon Drugs (3)DAVANAT, CINTREDEKIN BESUDOTOX, RECOMBINANT HUMAN INTERLEUKIN-15 |
| CMF-16052 | NFIX | up-regulates | DR1 | activates | R-2981 | 8 | 5 | Drugs (1) |
| CMF-16053 | NFIX | up-regulates | DR1 | activates | R-2987 | 8 | 5 | Drugs (4) |
| CMF-17306 | SYNJ2 | up-regulates | DR1 | activates | R-2981 | 8 | 3 | Drugs (1) |
| CMF-17307 | SYNJ2 | up-regulates | DR1 | activates | R-2987 | 8 | 3 | Drugs (4) |
| CMF-18218 | CDH19 | up-regulates | DR1 | activates | R-2981 | 8 | 2 | Drugs (1) |
| CMF-19751 | BVES | up-regulates | DR1 | activates | R-2982 | 8 | 4 | Drugs (3) Regulator Drugs (0)Regulon Drugs (3)DAVANAT, CINTREDEKIN BESUDOTOX, RECOMBINANT HUMAN INTERLEUKIN-15 |
| CMF-21347 | GRIK3 | up-regulates | DR1 | activates | R-2981 | 8 | 4 | Drugs (1) |
| CMF-21348 | GRIK3 | up-regulates | DR1 | activates | R-2987 | 8 | 4 | Drugs (4) |
| CMF-21650 | MUC17 | up-regulates | DR1 | activates | R-2981 | 8 | 5 | Drugs (1) |
| CMF-21651 | MUC17 | up-regulates | DR1 | activates | R-2987 | 8 | 5 | Drugs (4) |
| CMF-21652 | MUC17 | up-regulates | DR1 | activates | R-2982 | 8 | 5 | Drugs (3) Regulator Drugs (0)Regulon Drugs (3)DAVANAT, CINTREDEKIN BESUDOTOX, RECOMBINANT HUMAN INTERLEUKIN-15 |
| CMF-26962 | TMTC1 | down-regulates | DR1 | activates | R-2982 | 8 | 2 | Drugs (3) Regulator Drugs (0)Regulon Drugs (3)DAVANAT, CINTREDEKIN BESUDOTOX, RECOMBINANT HUMAN INTERLEUKIN-15 |
| CMF-30869 | ARMC4 | up-regulates | DR1 | activates | R-2987 | 8 | 1 | Drugs (4) |