Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

E2F3 - E2F transcription factor 3

Function

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
1871 ENSG00000112242 E2F3 O00716

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000112242 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-05329PCSK6down-regulatesE2F3activatesR-49662Drugs (64)
CMF-06211HYDINdown-regulatesE2F3activatesR-49661Drugs (64)
CMF-07128ATRXup-regulatesE2F3activatesR-49662Drugs (64)
CMF-09855ABP1down-regulatesE2F3activatesR-49661Drugs (64)
CMF-11805DNAH17up-regulatesE2F3activatesR-49662Drugs (64)
CMF-16339PRG4up-regulatesE2F3activatesR-49661Drugs (64)
CMF-17630ODZ1down-regulatesE2F3activatesR-49663Drugs (64)
CMF-20635ABCD2down-regulatesE2F3activatesR-49661Drugs (64)
CMF-22919IDH1up-regulatesE2F3activatesR-49662Drugs (64)
CMF-24058TP53up-regulatesE2F3activatesR-49665Drugs (64)
CMF-26510EGFRdown-regulatesE2F3activatesR-49661Drugs (64)
CMF-26707FBN2down-regulatesE2F3activatesR-49661Drugs (64)
CMF-27817CSMD3down-regulatesE2F3activatesR-49662Drugs (64)
CMF-28148IQCEdown-regulatesE2F3activatesR-49661Drugs (64)