Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
HOXA3 - homeobox A3
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 3200 | ENSG00000105997 | HOXA3 | O43365 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000105997 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00279 | SPTA1 | up-regulates | HOXA3 | represses | R-1474 | 22 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00280 | SPTA1 | up-regulates | HOXA3 | represses | R-1462 | 22 | 6 | Drugs (2) |
| CMF-01208 | IRAK3 | up-regulates | HOXA3 | represses | R-1467 | 22 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01462 | MTOR | down-regulates | HOXA3 | represses | R-1462 | 22 | 4 | Drugs (2) |
| CMF-01464 | MTOR | down-regulates | HOXA3 | represses | R-1470 | 22 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-01537 | CACNA1B | down-regulates | HOXA3 | represses | R-1463 | 22 | 7 | Drugs (1) |
| CMF-01541 | CACNA1B | down-regulates | HOXA3 | represses | R-1476 | 22 | 7 | Drugs (1) |
| CMF-01543 | CACNA1B | down-regulates | HOXA3 | represses | R-1470 | 22 | 7 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-01851 | DAO | up-regulates | HOXA3 | represses | R-1465 | 22 | 2 | Drugs (4) |
| CMF-02523 | MMP3 | down-regulates | HOXA3 | represses | R-1467 | 22 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-02786 | DHX30 | down-regulates | HOXA3 | represses | R-1465 | 22 | 1 | Drugs (4) |
| CMF-02975 | HFM1 | down-regulates | HOXA3 | represses | R-1466 | 22 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03320 | C14orf115 | down-regulates | HOXA3 | represses | R-1474 | 22 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03796 | DSP | down-regulates | HOXA3 | represses | R-1460 | 22 | 9 | Drugs (44) Regulator Drugs (0)Regulon Drugs (44)SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, AMUVATINIB, BIRINAPANT, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, MK-8033, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, NEDOSIRAN SODIUM, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN |
| CMF-03798 | DSP | down-regulates | HOXA3 | represses | R-1476 | 22 | 9 | Drugs (1) |
| CMF-04842 | NEFM | down-regulates | HOXA3 | represses | R-1467 | 22 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04845 | NEFM | down-regulates | HOXA3 | represses | R-1476 | 22 | 6 | Drugs (1) |
| CMF-06155 | MDGA2 | down-regulates | HOXA3 | represses | R-1465 | 22 | 6 | Drugs (4) |
| CMF-06157 | MDGA2 | down-regulates | HOXA3 | represses | R-1470 | 22 | 6 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-07251 | NOD2 | down-regulates | HOXA3 | represses | R-1466 | 22 | 10 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07253 | NOD2 | down-regulates | HOXA3 | represses | R-1463 | 22 | 10 | Drugs (1) |
| CMF-07255 | NOD2 | down-regulates | HOXA3 | represses | R-1460 | 22 | 10 | Drugs (44) Regulator Drugs (0)Regulon Drugs (44)SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, AMUVATINIB, BIRINAPANT, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, MK-8033, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, NEDOSIRAN SODIUM, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN |
| CMF-07257 | NOD2 | down-regulates | HOXA3 | represses | R-1476 | 22 | 10 | Drugs (1) |
| CMF-07259 | NOD2 | down-regulates | HOXA3 | represses | R-1462 | 22 | 10 | Drugs (2) |
| CMF-07260 | NOD2 | down-regulates | HOXA3 | represses | R-1465 | 22 | 10 | Drugs (4) |
| CMF-08526 | MYO3A | down-regulates | HOXA3 | represses | R-1474 | 22 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-10043 | ATP8A2 | up-regulates | HOXA3 | represses | R-1463 | 22 | 4 | Drugs (1) |
| CMF-12871 | ATP11C | down-regulates | HOXA3 | represses | R-1476 | 22 | 2 | Drugs (1) |
| CMF-13245 | SATL1 | up-regulates | HOXA3 | represses | R-1474 | 22 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-14328 | RIMS2 | down-regulates | HOXA3 | represses | R-1470 | 22 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-16188 | USP11 | up-regulates | HOXA3 | represses | R-1463 | 22 | 7 | Drugs (1) |
| CMF-16189 | USP11 | up-regulates | HOXA3 | represses | R-1467 | 22 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16191 | USP11 | up-regulates | HOXA3 | represses | R-1476 | 22 | 7 | Drugs (1) |
| CMF-24936 | NLRP1 | down-regulates | HOXA3 | represses | R-1463 | 22 | 2 | Drugs (1) |
| CMF-24937 | NLRP1 | down-regulates | HOXA3 | represses | R-1465 | 22 | 2 | Drugs (4) |
| CMF-25561 | ZNF727 | down-regulates | HOXA3 | represses | R-1466 | 22 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27208 | HTR3A | down-regulates | HOXA3 | represses | R-1474 | 22 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27232 | PCDH11X | up-regulates | HOXA3 | represses | R-1467 | 22 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27245 | PDYN | down-regulates | HOXA3 | represses | R-1470 | 22 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)AMG-780, MEDI-3617, ENIBARCIMAB, TREBANANIB, VANUCIZUMAB, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-27888 | CXorf22 | down-regulates | HOXA3 | represses | R-1466 | 22 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27890 | CXorf22 | down-regulates | HOXA3 | represses | R-1463 | 22 | 9 | Drugs (1) |
| CMF-27893 | CXorf22 | down-regulates | HOXA3 | represses | R-1460 | 22 | 9 | Drugs (44) Regulator Drugs (0)Regulon Drugs (44)SAVOLITINIB, TELISOTUZUMAB VEDOTIN, ATN-161, AMUVATINIB, BIRINAPANT, CABOZANTINIB, ALTIRATINIB, SGX-523, TEREVALEFIM, TEPOTINIB HYDROCHLORIDE, FORETINIB, ONARTUZUMAB, SAR-125844, AMG-208, CILENGITIDE, TIROFIBAN HYDROCHLORIDE, MK-8033, AMG-337, ABCIXIMAB, CAPMATINIB HYDROCHLORIDE, AMIVANTAMAB, MK-2461, MERESTINIB, BMS-777607, CAPMATINIB, ETARACIZUMAB, JNJ-38877605, GLESATINIB, INTETUMUMAB, BMS-817378, CABOZANTINIB S-MALATE, CRIZOTINIB, EMD-1204831, TIVANTINIB, NEDOSIRAN SODIUM, TELISOTUZUMAB, TEPOTINIB, EMIBETUZUMAB, BPI-9016, PF-04217903, EPTIFIBATIDE, ABITUZUMAB, GOLVATINIB, TIROFIBAN |
| CMF-27895 | CXorf22 | down-regulates | HOXA3 | represses | R-1474 | 22 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28015 | LCT | down-regulates | HOXA3 | represses | R-1467 | 22 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29298 | C12orf51 | down-regulates | HOXA3 | represses | R-1474 | 22 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30748 | POLRMT | down-regulates | HOXA3 | represses | R-1465 | 22 | 2 | Drugs (4) |