Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
TP73 - tumor protein p73
Function
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 7161 | ENSG00000078900 | TP73 | A0A0C4DFW9 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000078900 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-03466 | AK7 | down-regulates | TP73 | represses | R-1962 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04167 | ESPNP | down-regulates | TP73 | represses | R-1962 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04767 | ADAMTS20 | down-regulates | TP73 | represses | R-1962 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04862 | NEFM | down-regulates | TP73 | represses | R-1962 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09125 | NLRP3 | down-regulates | TP73 | represses | R-1962 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-10989 | BMP5 | down-regulates | TP73 | represses | R-1962 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11890 | PALM2-AKAP2 | down-regulates | TP73 | represses | R-1962 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12900 | KCNS2 | down-regulates | TP73 | represses | R-1962 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16707 | SI | down-regulates | TP73 | represses | R-1962 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-19447 | NF1 | down-regulates | TP73 | represses | R-1962 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23903 | TP53 | up-regulates | TP73 | represses | R-1962 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24517 | SEMA3C | up-regulates | TP73 | represses | R-1962 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28152 | CACNA1H | down-regulates | TP73 | represses | R-1962 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |