Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation KCNS2_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-12892 | KCNS2 | down-regulates | SOX12 | represses | R-1100 | 18 | 3 | Drugs (2) |
| CMF-12893 | KCNS2 | down-regulates | SOX12 | activates | R-1105 | 18 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12894 | KCNS2 | down-regulates | SOX12 | represses | R-1107 | 18 | 3 | Drugs (4) |
| CMF-12899 | KCNS2 | down-regulates | ZIC1 | activates | R-3438 | 8 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12900 | KCNS2 | down-regulates | TP73 | represses | R-1962 | 1 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12901 | KCNS2 | down-regulates | POU4F2 | represses | R-2784 | 13 | 1 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, IMGN-388, CILENGITIDE, ABCIXIMAB, DIAZOXIDE, ETARACIZUMAB, INTETUMUMAB, STX-100, ABITUZUMAB |
| CMF-12904 | KCNS2 | down-regulates | NKX6-1 | represses | R-2852 | 20 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12910 | KCNS2 | down-regulates | NFIX | represses | R-1330 | 9 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12912 | KCNS2 | down-regulates | POU2F1 | represses | R-1443 | 19 | 1 | Drugs (42) Regulator Drugs (0)Regulon Drugs (42)EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR |
| CMF-37423 | KCNS2 | down-regulates | hsa-mir-9 | represses | R-1091 | 25 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |