Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
ZNF263 - zinc finger protein 263
Function
Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553). Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553). Acts as transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 10127 | ENSG00000006194 | ZNF263 | O14978 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000006194 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-02567 | PLCL1 | down-regulates | ZNF263 | activates | R-564 | 20 | 2 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-02973 | HFM1 | down-regulates | ZNF263 | activates | R-557 | 20 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03749 | DSP | up-regulates | ZNF263 | activates | R-557 | 20 | 10 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-05047 | ITPR3 | up-regulates | ZNF263 | activates | R-560 | 20 | 1 | Drugs (1) |
| CMF-05222 | C6orf170 | up-regulates | ZNF263 | activates | R-557 | 20 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07530 | ANO7 | down-regulates | ZNF263 | activates | R-560 | 20 | 3 | Drugs (1) |
| CMF-07531 | ANO7 | down-regulates | ZNF263 | activates | R-553 | 20 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, GSK-690693 |
| CMF-07532 | ANO7 | down-regulates | ZNF263 | activates | R-556 | 20 | 3 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-08751 | FBLN2 | up-regulates | ZNF263 | activates | R-564 | 20 | 8 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-08754 | FBLN2 | up-regulates | ZNF263 | activates | R-556 | 20 | 8 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-08904 | OAS2 | up-regulates | ZNF263 | activates | R-556 | 20 | 1 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-09150 | PRKCB | down-regulates | ZNF263 | activates | R-560 | 20 | 1 | Drugs (1) |
| CMF-09598 | OR9G9 | up-regulates | ZNF263 | activates | R-564 | 20 | 5 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-09599 | OR9G9 | up-regulates | ZNF263 | activates | R-553 | 20 | 5 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, GSK-690693 |
| CMF-09600 | OR9G9 | up-regulates | ZNF263 | activates | R-556 | 20 | 5 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-10301 | FGG | up-regulates | ZNF263 | activates | R-557 | 20 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-10608 | ITIH5L | up-regulates | ZNF263 | activates | R-557 | 20 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12583 | CD22 | up-regulates | ZNF263 | activates | R-556 | 20 | 2 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-14896 | SDHAP3 | up-regulates | ZNF263 | activates | R-560 | 20 | 4 | Drugs (1) |
| CMF-14898 | SDHAP3 | up-regulates | ZNF263 | activates | R-564 | 20 | 4 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-14899 | SDHAP3 | up-regulates | ZNF263 | activates | R-556 | 20 | 4 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)BEVACIZUMAB, CONBERCEPT, PEGAPTANIB SODIUM, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, ABICIPAR PEGOL, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-23494 | CUBN | up-regulates | ZNF263 | activates | R-557 | 20 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23662 | TP53 | up-regulates | ZNF263 | activates | R-557 | 20 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26304 | CHGB | up-regulates | ZNF263 | activates | R-560 | 20 | 2 | Drugs (1) |
| CMF-26305 | CHGB | up-regulates | ZNF263 | activates | R-553 | 20 | 2 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)VANDETANIB, TESEVATINIB, JI-101, TG100-801, OCRIPLASMIN, GSK-690693 |
| CMF-26358 | ZFHX4 | down-regulates | ZNF263 | activates | R-557 | 20 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |