Program – gbmMINER Portal

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Program – gbmMINER Portal

Program

Program Pr-92

Genes (45)

DTWD1, TMEM106B, STAM2, ACADM, BLZF1, FASTKD2, NDUFA5, DPY19L4, ZCCHC4, SLC39A9, U2AF2, METTL4, DNAJC17, ILVBL, GRWD1, ARMC6, ERF, AKAP7, RNF185, HAPLN1, ATP5A1, PLEKHA2, SOCS6, TLE1, ADA, TAF11, SLC25A17, NUTF2, CLEC11A, LSM5, AHR, UCHL3, ZNF639, TMEM177, UBB, P2RY14, ST20, TRAPPC2, ZNF468, SACM1L, H2AFJ, LIAS, FAHD2A, CYCS, LIN7C

Regulons (16)

R-132, R-422, R-595, R-664, R-740, R-2204, R-2235, R-2360, R-2602, R-2725, R-2923, R-3247, R-3457, R-3502, R-3678, R-3750

Regulons in program Pr-92

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-132	-0.041136	9	4
R-422	-0.187269	17	16
R-595	-0.0256344	8	7
R-664	-1.37875	8	17
R-740	0.146856	16	6
R-2204	0.670929	5	8
R-2235	1.93985	5	7
R-2360	1.44491	7	6
R-2602	-1.13584	7	7
R-2725	0.851346	8	11
R-2923	-0.0526506	6	7
R-3247	0.931079	8	3
R-3457	0.0202386	5	7
R-3502	-1.51612	6	4
R-3678	1.96962	6	2
R-3750	1.52258	6	4

Genes in program Pr-92

EnsEMBL Id	Entrez Id	Preferred
ENSG00000104047	56986	DTWD1
ENSG00000106460	54664	TMEM106B
ENSG00000115145	10254	STAM2
ENSG00000117054	34	ACADM
ENSG00000117475	8548	BLZF1
ENSG00000118246	22868	FASTKD2
ENSG00000128609	4698	NDUFA5
ENSG00000156162	286148	DPY19L4
ENSG00000168228	29063	ZCCHC4
ENSG00000029364	55334	SLC39A9
ENSG00000063244	11338	U2AF2
ENSG00000101574	64863	METTL4
ENSG00000104129	55192	DNAJC17
ENSG00000105135	10994	ILVBL
ENSG00000105447	83743	GRWD1
ENSG00000105676	93436	ARMC6
ENSG00000105722	2077	ERF
ENSG00000118507	9465	AKAP7
ENSG00000138942	91445	RNF185
ENSG00000145681	1404	HAPLN1
ENSG00000152234	498	ATP5A1
ENSG00000169499	59339	PLEKHA2
ENSG00000170677	9306	SOCS6
ENSG00000196781	7088	TLE1
ENSG00000196839	100	ADA
ENSG00000064995	6882	TAF11
ENSG00000100372	10478	SLC25A17
ENSG00000102898	10204	NUTF2
ENSG00000105472	6320	CLEC11A
ENSG00000106355	23658	LSM5
ENSG00000106546	196	AHR
ENSG00000118939	7347	UCHL3
ENSG00000121864	51193	ZNF639
ENSG00000144120	80775	TMEM177
ENSG00000170315	7314	UBB
ENSG00000174944	9934	P2RY14
ENSG00000180953	400410	ST20
ENSG00000196459	6399	TRAPPC2
ENSG00000204604	90333	ZNF468
ENSG00000211456	22908	SACM1L
ENSG00000246705	55766	H2AFJ
ENSG00000121897	11019	LIAS
ENSG00000115042	51011	FAHD2A
ENSG00000172115	54205	CYCS
ENSG00000148943	55327	LIN7C

Causal Mechanistic Flows with Program Pr-92

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-14785	ZNF681	up-regulates	NFIL3	activates	R-3678	7	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TAPINAROF
CMF-20355	OR8H2	up-regulates	NFIL3	activates	R-3678	7	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) TAPINAROF

CMFlow summary not available

Enrichment summary not available