Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows regulated by Mutation UPF1_code_potential_somatic

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-19025UPF1down-regulatesPOU2F3repressesR-1706164Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

2X-121

CMF-19029UPF1up-regulatesTBPactivatesR-3460182Drugs (11)
CMF-19040UPF1down-regulatesHSF4repressesR-279741Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

OCRIPLASMIN

CMF-19045UPF1down-regulatesFOXO4repressesR-3103173Drugs (8)
CMF-39344UPF1down-regulateshsa-mir-346repressesR-21232016Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BRENSOCATIB

CMF-39345UPF1down-regulateshsa-mir-346repressesR-21612016Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BRENSOCATIB, EMRICASAN

CMF-39346UPF1down-regulateshsa-mir-346repressesR-1172016Drugs (16)
CMF-39347UPF1down-regulateshsa-mir-346repressesR-3972016Drugs (16)
CMF-39348UPF1down-regulateshsa-mir-346repressesR-4192016Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BRENSOCATIB, EMRICASAN

CMF-39349UPF1down-regulateshsa-mir-346repressesR-24772016Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BRENSOCATIB, EMRICASAN

CMF-39350UPF1down-regulateshsa-mir-346repressesR-25852016Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-39351UPF1down-regulateshsa-mir-346repressesR-27672016Drugs (16)
CMF-39352UPF1down-regulateshsa-mir-346repressesR-7372016Drugs (17)
CMF-39353UPF1down-regulateshsa-mir-346repressesR-28852016Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BRENSOCATIB

CMF-39354UPF1down-regulateshsa-mir-346repressesR-31342016Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BRENSOCATIB

CMF-39355UPF1down-regulateshsa-mir-346repressesR-33482016Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

EMRICASAN

CMF-39356UPF1down-regulateshsa-mir-346repressesR-15922016Drugs (17)
CMF-39357UPF1down-regulateshsa-mir-346repressesR-16792016Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-39358UPF1down-regulateshsa-mir-346repressesR-18292016Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BRENSOCATIB, EMRICASAN

CMF-39359UPF1down-regulateshsa-mir-346repressesR-19262016Drugs (15)
CMF-39360UPF1down-regulateshsa-mir-328repressesR-158272Drugs (110)
CMF-39361UPF1down-regulateshsa-mir-328repressesR-257272Drugs (149)

Regulator Drugs (0)

Regulon Drugs (149)

PF-04691502, FOSTAMATINIB DISODIUM, PICOTAMIDE, INFLIXIMAB, UMBRALISIB, MIDOSTAURIN, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, RUPATADINE, HYDROXYCHLOROQUINE, TERBOGREL, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, PICLIDENOSON, NEMIRALISIB, RP-6530, APITOLISIB, DASATINIB, DS-7423, GSK-2269557, ABATACEPT, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, CCR5MAB004, R-348, AMY-101, PEGSUNERCEPT, GOLIMUMAB, VICRIVIROC, CAFFEINE, CITRATED, MEDI-2338, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, AVE-9633, VOBARILIZUMAB, CERDULATINIB, VESATOLIMOD, DUVELISIB, L19TNFA, APLAVIROC, MARAVIROC, AZD-8848, DACTOLISIB, BOSUTINIB, BAFETINIB, ZANDELISIB, HMPL-523, ETANERCEPT, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, LERONLIMAB, AFELIMOMAB, SOTRASTAURIN, OZORALIZUMAB, PILARALISIB, ILORASERTIB, CERTOLIZUMAB PEGOL, TASELISIB, JNJ-26483327, L19SIP 131I, AMG-319, UCN-01, TADEKINIG ALFA, HYDROXYCHLOROQUINE SULFATE, HGS-1025, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, GEMTUZUMAB, CENICRIVIROC, IDELALISIB, APLAVIROC HYDROCHLORIDE, BELATACEPT, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, CPG-52852, SELGANTOLIMOD, R-333, IMIQUIMOD, GUSACITINIB, REMTOLUMAB, TOLIMIDONE, CAFFEINE, MOTOLIMOD, TOMIVOSERTIB, BMS-813160, GEMTUZUMAB OZOGAMICIN, PF-04634817, TG100-801, INCB-9471, PEGCETACOPLAN, VICRIVIROC MALEATE, ADENOSINE, DUPILUMAB, ACALISIB, PF-232798, GSK-2245035, MIVAVOTINIB CITRATE, VELIFLAPON, TELRATOLIMOD, AZD5672, OCRIPLASMIN, CAL-263, OXTRIPHYLLINE, ADALIMUMAB, MILATUZUMAB, FOSTAMATINIB, NAMODENOSON, LENIOLISIB, OZAGREL, PA-799, PLACULUMAB, LINTUZUMAB, DELCASERTIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, BUPARLISIB, VESENCUMAB, GSK-690693, THEOPHYLLINE, SF-1126, AMINOPHYLLINE, GSK-1070806, FIBOFLAPON, AL-78898A, ENMD-981693, PANULISIB

CMF-39362UPF1down-regulateshsa-mir-139repressesR-1175813Drugs (16)
CMF-39363UPF1down-regulateshsa-mir-139repressesR-3975813Drugs (16)
CMF-39364UPF1down-regulateshsa-mir-139repressesR-4195813Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BRENSOCATIB, EMRICASAN

CMF-39365UPF1down-regulateshsa-mir-139repressesR-24775813Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BRENSOCATIB, EMRICASAN

CMF-39366UPF1down-regulateshsa-mir-139repressesR-25855813Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-39367UPF1down-regulateshsa-mir-139repressesR-27605813Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-39368UPF1down-regulateshsa-mir-139repressesR-7375813Drugs (17)
CMF-39369UPF1down-regulateshsa-mir-139repressesR-28855813Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BRENSOCATIB

CMF-39370UPF1down-regulateshsa-mir-139repressesR-31345813Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BRENSOCATIB

CMF-39371UPF1down-regulateshsa-mir-139repressesR-33485813Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

EMRICASAN

CMF-39372UPF1down-regulateshsa-mir-139repressesR-15925813Drugs (17)
CMF-39373UPF1down-regulateshsa-mir-139repressesR-18295813Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BRENSOCATIB, EMRICASAN

CMF-39374UPF1down-regulateshsa-mir-139repressesR-16715813Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BARDOXOLONE METHYL