| CMF-24909 | NLRP1 | up-regulates | IRF9 | activates | R-1446 | 15 | 5 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, ONO-2952, CARFILZOMIB |
| CMF-24911 | NLRP1 | up-regulates | IRF9 | activates | R-1451 | 15 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24913 | NLRP1 | up-regulates | PAX6 | activates | R-1285 | 16 | 3 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-24914 | NLRP1 | up-regulates | PAX6 | activates | R-1294 | 16 | 3 | Drugs (5) |
| CMF-24915 | NLRP1 | up-regulates | IRF2 | activates | R-431 | 25 | 7 | Drugs (1) |
| CMF-24916 | NLRP1 | up-regulates | IRF2 | activates | R-426 | 25 | 7 | Drugs (11) Regulator Drugs (0)Regulon Drugs (11)AMG-780, MEDI-3617, ENIBARCIMAB, F16SIP 131I, TREBANANIB, F16IL2, VANUCIZUMAB, PROBUCOL, FARICIMAB, CVX-060, NESVACUMAB |
| CMF-24917 | NLRP1 | up-regulates | IRF2 | activates | R-413 | 25 | 7 | Drugs (139) Regulator Drugs (0)Regulon Drugs (139)PF-04691502, FOSTAMATINIB DISODIUM, PICOTAMIDE, UMBRALISIB, FIBOFLAPON SODIUM, ATN-161, BGT-226, SONOLISIB, CSL-324, TERBOGREL, PARSACLISIB, INTERFERON GAMMA-1B, R-343, VOXTALISIB, BMS-986142, HM-71224, NEMIRALISIB, RP-6530, BIIB-023, APITOLISIB, AME-133V, DASATINIB, DS-7423, GSK-2269557, L19IL2, INCB-40093, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, R-348, PF-06651600, AMY-101, LIPEGFILGRASTIM, ABIVERTINIB, VRC-01LS, ABIVERTINIB MALEATE, MEDI-2338, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, VOBARILIZUMAB, CERDULATINIB, DUVELISIB, CAROTUXIMAB, L19TNFA, EFALIZUMAB, DACTOLISIB, BOSUTINIB, FILGRASTIM, ZANDELISIB, HMPL-523, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, RILZABRUTINIB, BALUGRASTIM, SPEBRUTINIB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, RO-5458640, TASELISIB, L19SIP 131I, AMG-319, IBRUTINIB, TADEKINIG ALFA, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, SELETALISIB, PF-04605412, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, IDELALISIB, ZANUBRUTINIB, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, EVOBRUTINIB, SELGANTOLIMOD, R-333, OTLERTUZUMAB, GUSACITINIB, BI-836826, MOTOLIMOD, TREGALIZUMAB, ERITORAN TETRASODIUM, TG100-801, SPEBRUTINIB BESYLATE, PEGCETACOPLAN, LENOGRASTIM, POSELTINIB, LIFITEGRAST, VB-201, ACALISIB, ZANOLIMUMAB, MIVAVOTINIB CITRATE, VELIFLAPON, PIRTOBRUTINIB, TELRATOLIMOD, IBALIZUMAB, OCRIPLASMIN, CAL-263, UB-421, ACALABRUTINIB, ERITORAN, MILATUZUMAB, VOLOCIXIMAB, FOSTAMATINIB, TOMARALIMAB, ELSUBRUTINIB, BRANEBRUTINIB, LENIOLISIB, OZAGREL, PA-799, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, PEGFILGRASTIM, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, SF-1126, ORELABRUTINIB, GSK-1070806, FIBOFLAPON, AL-78898A, ENMD-981693, PANULISIB |
| CMF-24918 | NLRP1 | up-regulates | IRF2 | activates | R-416 | 25 | 7 | Drugs (10) |
| CMF-24919 | NLRP1 | up-regulates | IRF2 | activates | R-419 | 25 | 7 | Drugs (2) |
| CMF-24922 | NLRP1 | down-regulates | LHX1 | represses | R-2964 | 17 | 4 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-24924 | NLRP1 | down-regulates | LHX1 | represses | R-2972 | 17 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24927 | NLRP1 | down-regulates | PAX1 | represses | R-254 | 3 | 2 | Drugs (29) Regulator Drugs (0)Regulon Drugs (29)RUPATADINE, CSL-324, DASATINIB, LIPEGFILGRASTIM, MEDI-2338, CAROTUXIMAB, BOSUTINIB, BAFETINIB, FILGRASTIM, BALUGRASTIM, ILORASERTIB, JNJ-26483327, TADEKINIG ALFA, PETESICATIB, NEIHULIZUMAB, XL-228, OTLERTUZUMAB, BI-836826, TOLIMIDONE, ERITORAN TETRASODIUM, TG100-801, LENOGRASTIM, OCRIPLASMIN, ERITORAN, PEGFILGRASTIM, NARATUXIMAB EMTANSINE, AMG-557, GSK-1070806, ENMD-981693 |
| CMF-24934 | NLRP1 | up-regulates | ELF1 | activates | R-326 | 24 | 6 | Drugs (124) Regulator Drugs (0)Regulon Drugs (124)PF-04691502, FOSTAMATINIB DISODIUM, PICOTAMIDE, SARGRAMOSTIM, UMBRALISIB, MIDOSTAURIN, FIBOFLAPON SODIUM, BGT-226, SONOLISIB, RUPATADINE, CSL-324, TERBOGREL, PARSACLISIB, INTERFERON GAMMA-1B, R-343, VOXTALISIB, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, APITOLISIB, AME-133V, DASATINIB, DS-7423, GSK-2269557, L19IL2, INCB-40093, PAXALISIB, AS-1409, PICTILISIB, CCR5MAB004, R-348, AMY-101, LIPEGFILGRASTIM, VICRIVIROC, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, VOBARILIZUMAB, CERDULATINIB, DUVELISIB, CAROTUXIMAB, L19TNFA, APLAVIROC, MARAVIROC, EFALIZUMAB, DACTOLISIB, FILGRASTIM, ZANDELISIB, HMPL-523, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, LERONLIMAB, BALUGRASTIM, SOTRASTAURIN, PILARALISIB, ILORASERTIB, MUPARFOSTAT, PREXIGEBERSEN, TASELISIB, L19SIP 131I, AMG-319, UCN-01, HGS-1025, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, SELETALISIB, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, CENICRIVIROC, IDELALISIB, APLAVIROC HYDROCHLORIDE, XL-228, FIMEPINOSTAT, ENTOSPLETINIB, SATRALIZUMAB, R-333, OTLERTUZUMAB, GUSACITINIB, BI-836826, MAVRILIMUMAB, ERITORAN TETRASODIUM, BMS-813160, PF-04634817, TG100-801, INCB-9471, PEGCETACOPLAN, VICRIVIROC MALEATE, LENOGRASTIM, LIFITEGRAST, DUPILUMAB, ACALISIB, PF-232798, MIVAVOTINIB CITRATE, VELIFLAPON, AZD5672, OCRIPLASMIN, CAL-263, ERITORAN, MILATUZUMAB, FOSTAMATINIB, LENIOLISIB, OZAGREL, PA-799, DELCASERTIB, LEVILIMAB, GSK-1059615, LANRAPLENIB, MIVAVOTINIB, PEGFILGRASTIM, BUPARLISIB, NARATUXIMAB EMTANSINE, GSK-690693, SF-1126, FIBOFLAPON, AL-78898A, ENMD-981693, PANULISIB |
| CMF-24936 | NLRP1 | down-regulates | HOXA3 | represses | R-1463 | 22 | 2 | Drugs (1) |
| CMF-24937 | NLRP1 | down-regulates | HOXA3 | represses | R-1465 | 22 | 2 | Drugs (4) |
| CMF-24938 | NLRP1 | up-regulates | IRF1 | activates | R-112 | 25 | 10 | Drugs (161) Regulator Drugs (0)Regulon Drugs (161)PF-04691502, PICOTAMIDE, INFLIXIMAB, UMBRALISIB, ATN-161, BGT-226, SONOLISIB, CSL-324, HYDROXYCHLOROQUINE, TERBOGREL, PARSACLISIB, INTERFERON GAMMA-1B, ONERCEPT, VOXTALISIB, BMS-986142, HM-71224, CINTREDEKIN BESUDOTOX, NEMIRALISIB, RP-6530, BIIB-023, APITOLISIB, AME-133V, DASATINIB, DS-7423, GSK-2269557, L19IL2, INCB-40093, MSC-2364447, PAXALISIB, AS-1409, PICTILISIB, CCR5MAB004, PF-06651600, AMY-101, LIPEGFILGRASTIM, PEGSUNERCEPT, ABIVERTINIB, VRC-01LS, GOLIMUMAB, ABIVERTINIB MALEATE, VICRIVIROC, MEDI-2338, TG100-115, VS-5584, COPANLISIB, SAMOTOLISIB, VOBARILIZUMAB, VESATOLIMOD, DUVELISIB, CAROTUXIMAB, L19TNFA, APLAVIROC, MARAVIROC, AZD-8848, EFALIZUMAB, DACTOLISIB, BOSUTINIB, FILGRASTIM, ZANDELISIB, ETANERCEPT, TOCILIZUMAB, AZD-8186, GNF-Pf-5468, WX-037, LERONLIMAB, RILZABRUTINIB, BALUGRASTIM, AFELIMOMAB, SPEBRUTINIB, OZORALIZUMAB, PILARALISIB, ILORASERTIB, DAPANSUTRILE, CERTOLIZUMAB PEGOL, RO-5458640, TASELISIB, L19SIP 131I, AMG-319, IBRUTINIB, TADEKINIG ALFA, HYDROXYCHLOROQUINE SULFATE, HGS-1025, COPANLISIB HYDROCHLORIDE, TENALISIB, PETESICATIB, SELETALISIB, PF-04605412, GEDATOLISIB, OMIPALISIB, SARILUMAB, UMBRALISIB TOSYLATE, NEIHULIZUMAB, ENTOLIMOD, CENICRIVIROC, IDELALISIB, APLAVIROC HYDROCHLORIDE, ZANUBRUTINIB, XL-228, FIMEPINOSTAT, SATRALIZUMAB, EVOBRUTINIB, CPG-52852, SELGANTOLIMOD, IMIQUIMOD, OTLERTUZUMAB, REMTOLUMAB, BI-836826, MOTOLIMOD, TREGALIZUMAB, ERITORAN TETRASODIUM, TOMIVOSERTIB, BMS-813160, PF-04634817, TG100-801, INCB-9471, SPEBRUTINIB BESYLATE, PEGCETACOPLAN, VICRIVIROC MALEATE, LENOGRASTIM, POSELTINIB, LIFITEGRAST, VB-201, ACALISIB, PF-232798, ZANOLIMUMAB, GSK-2245035, PIRTOBRUTINIB, TELRATOLIMOD, AZD5672, IBALIZUMAB, OCRIPLASMIN, CAL-263, UB-421, ACALABRUTINIB, ERITORAN, ADALIMUMAB, MILATUZUMAB, VOLOCIXIMAB, TOMARALIMAB, ELSUBRUTINIB, BRANEBRUTINIB, LENIOLISIB, OZAGREL, PA-799, PLACULUMAB, TIRABRUTINIB, FENEBRUTINIB, LEVILIMAB, GSK-1059615, PEGFILGRASTIM, BUPARLISIB, VESENCUMAB, NARATUXIMAB EMTANSINE, AMG-557, SF-1126, ORELABRUTINIB, GSK-1070806, AL-78898A, ENMD-981693, PANULISIB, NELFINAVIR |
| CMF-24940 | NLRP1 | up-regulates | IRF1 | activates | R-121 | 25 | 10 | Drugs (20) Regulator Drugs (0)Regulon Drugs (20)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-24941 | NLRP1 | up-regulates | IRF1 | activates | R-119 | 25 | 10 | Drugs (1) Regulator Drugs (0)Regulon Drugs (1)DIAZOXIDE |
| CMF-24943 | NLRP1 | up-regulates | IRF1 | activates | R-123 | 25 | 10 | Drugs (1) |
| CMF-24944 | NLRP1 | up-regulates | IRF1 | activates | R-133 | 25 | 10 | Drugs (42) Regulator Drugs (0)Regulon Drugs (42)EFATUTAZONE, FARGLITAZAR, SAROGLITAZAR, CHIGLITAZAR, PIOGLITAZONE HYDROCHLORIDE, OLSALAZINE, TROXACITABINE, CLOFARABINE, MURAGLITAZAR, BALAGLITAZONE, MK-0767, INT131, BEZAFIBRATE, TESAGLITAZAR, ROSIGLITAZONE MALEATE, CYTARABINE, DB959, GEMCITABINE HYDROCHLORIDE, ETALOCIB, OLSALAZINE SODIUM, MESALAMINE, ATX08-001, SODELGLITAZAR, GEMCITABINE, BALSALAZIDE DISODIUM, TROGLITAZONE, IMIGLITAZAR, MK-0533, ASPACYTARABINE, BARDOXOLONE METHYL, BALSALAZIDE, FLUDARABINE PHOSPHATE, LERIGLITAZONE, RIVOGLITAZONE, ARHALOFENATE, MBX-2044, PIOGLITAZONE, NAVEGLITAZAR, LANIFIBRANOR, INDEGLITAZAR, ROSIGLITAZONE, ALEGLITAZAR |
| CMF-24946 | NLRP1 | up-regulates | IRF1 | activates | R-115 | 25 | 10 | Drugs (13) Regulator Drugs (0)Regulon Drugs (13)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ALEMTUZUMAB, ONO-2952, CARFILZOMIB |
| CMF-24948 | NLRP1 | down-regulates | FEV | represses | R-3034 | 5 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24949 | NLRP1 | down-regulates | FEV | represses | R-3032 | 5 | 3 | Drugs (18) Regulator Drugs (0)Regulon Drugs (18)FOSTAMATINIB DISODIUM, FIBOFLAPON SODIUM, R-343, AME-133V, R-348, CERDULATINIB, EFALIZUMAB, HMPL-523, ENTOSPLETINIB, R-333, GUSACITINIB, LIFITEGRAST, MIVAVOTINIB CITRATE, VELIFLAPON, FOSTAMATINIB, LANRAPLENIB, MIVAVOTINIB, FIBOFLAPON |
| CMF-24950 | NLRP1 | down-regulates | FEV | represses | R-3031 | 5 | 3 | Drugs (2) |
| CMF-24953 | NLRP1 | up-regulates | SOX9 | activates | R-1225 | 16 | 5 | Drugs (9) |
| CMF-24956 | NLRP1 | down-regulates | RREB1 | represses | R-892 | 15 | 1 | Drugs (18) Regulator Drugs (0)Regulon Drugs (18)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-24958 | NLRP1 | down-regulates | LHX3 | represses | R-2002 | 24 | 3 | Drugs (19) Regulator Drugs (0)Regulon Drugs (19)BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB |
| CMF-24959 | NLRP1 | down-regulates | LHX3 | represses | R-2008 | 24 | 3 | Drugs (1) |
| CMF-24961 | NLRP1 | up-regulates | NR3C2 | activates | R-2018 | 2 | 1 | Drugs (3) |
| CMF-24974 | NLRP1 | down-regulates | LHX5 | represses | R-3056 | 11 | 4 | Drugs (8) |
| CMF-24976 | NLRP1 | down-regulates | LHX5 | represses | R-3061 | 11 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24991 | NLRP1 | down-regulates | PAX2 | represses | R-1185 | 4 | 3 | Drugs (1) |
| CMF-24993 | NLRP1 | down-regulates | VSX1 | represses | R-2355 | 16 | 5 | Drugs (83) Regulator Drugs (0)Regulon Drugs (83)IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, MELOXICAM, BROMFENAC SODIUM, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, MEDI-5117, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, CLAZAKIZUMAB, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, OLOKIZUMAB, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, SILTUXIMAB, MRA 003 US, ACEMETACIN, PARECOXIB SODIUM, IBUPROFEN SODIUM, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, PF-04236921, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, GLEMBATUMUMAB VEDOTIN, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, GLEMBATUMUMAB, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, SIRUKUMAB, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, POLMACOXIB, ZILTIVEKIMAB |
| CMF-24994 | NLRP1 | down-regulates | VSX1 | represses | R-2364 | 16 | 5 | Drugs (2) |
| CMF-24996 | NLRP1 | down-regulates | VSX1 | represses | R-2358 | 16 | 5 | Drugs (2) |
| CMF-24997 | NLRP1 | down-regulates | VSX1 | represses | R-2362 | 16 | 5 | Drugs (8) |
| CMF-25001 | NLRP1 | up-regulates | MSX1 | activates | R-2817 | 12 | 5 | Drugs (10) |
| CMF-25002 | NLRP1 | up-regulates | MSX1 | activates | R-2821 | 12 | 5 | Drugs (1) |
| CMF-41762 | NLRP1 | down-regulates | hsa-mir-329 | represses | R-2224 | 6 | 1 | Drugs (1) |