Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation IL6_MEDIATED_SIGNALING_EVENTS_PID_NCI_NATURE_nonsilent_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-33701 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF9 | activates | R-1457 | 15 | 3 | Drugs (2) |
| CMF-33706 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF2 | activates | R-424 | 25 | 5 | Drugs (4) |
| CMF-33712 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | MAF | activates | R-189 | 19 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-33714 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF7 | activates | R-2479 | 21 | 7 | Drugs (2) |
| CMF-33715 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF7 | activates | R-2489 | 21 | 7 | Drugs (2) |
| CMF-33716 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF7 | activates | R-2491 | 21 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-33717 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF7 | activates | R-2482 | 21 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-33718 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF7 | activates | R-2485 | 21 | 7 | Drugs (2) |
| CMF-33719 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF7 | activates | R-2476 | 21 | 7 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)OPROZOMIB, INTERFERON GAMMA-1B, IXAZOMIB, MARIZOMIB, NIVOCASAN, BORTEZOMIB, EMRICASAN, EMAPUNIL, BELNACASAN, IXAZOMIB CITRATE, ONO-2952, CARFILZOMIB |
| CMF-33720 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | IRF7 | activates | R-2495 | 21 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-33725 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | EP300 | activates | R-3413 | 5 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-33731 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | STAT5B | activates | R-1544 | 9 | 2 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)BINTRAFUSP ALFA, TRILACICLIB, RIBOCICLIB, PALBOCICLIB, ABEMACICLIB, PHA-793887, LUSPATERCEPT, AZD-5438, RIBOCICLIB SUCCINATE, TRILACICLIB DIHYDROCHLORIDE, UCN-01, ALVOCIDIB, FRESOLIMUMAB, RONICICLIB, AT-7519, MARIMASTAT |
| CMF-33732 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | CEBPA | activates | R-2605 | 21 | 1 | Drugs (2) |
| CMF-33736 | IL6_MEDIATED_SIGNALING_EVENTS | up-regulates | KLF4 | activates | R-2120 | 10 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |