Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows regulated by Mutation CYP4F12_code_potential_somatic
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-04624 | CYP4F12 | up-regulates | TEAD1 | represses | R-2400 | 15 | 1 | Drugs (2) |
| CMF-04625 | CYP4F12 | down-regulates | CDX1 | activates | R-3126 | 7 | 3 | Drugs (2) |
| CMF-04627 | CYP4F12 | down-regulates | CDX1 | activates | R-3131 | 7 | 3 | Drugs (5) |
| CMF-04630 | CYP4F12 | down-regulates | SREBF1 | activates | R-2503 | 12 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04631 | CYP4F12 | down-regulates | SREBF1 | activates | R-2501 | 12 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04640 | CYP4F12 | up-regulates | TCF3 | represses | R-1592 | 18 | 2 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-04644 | CYP4F12 | up-regulates | MYCN | represses | R-1806 | 5 | 2 | Drugs (2) |
| CMF-04646 | CYP4F12 | down-regulates | RUNX3 | activates | R-196 | 11 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-34701 | CYP4F12 | up-regulates | hsa-mir-93 | represses | R-2123 | 44 | 14 | Drugs (1) |
| CMF-34702 | CYP4F12 | up-regulates | hsa-mir-93 | represses | R-117 | 44 | 14 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-34703 | CYP4F12 | up-regulates | hsa-mir-93 | represses | R-2412 | 44 | 14 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-34704 | CYP4F12 | up-regulates | hsa-mir-93 | represses | R-371 | 44 | 14 | Drugs (31) Regulator Drugs (0)Regulon Drugs (31)RILAPLADIB, CALCIFEDIOL, BECOCALCIDIOL, TACROLIMUS, INTERFERON GAMMA-1B, TEMSIROLIMUS, PARICALCITOL, INECALCITOL, BATOCLIMAB, ERGOCALCIFEROL, CHOLECALCIFEROL, NIPOCALIMAB, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, EVEROLIMUS, DARAPLADIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SIROLIMUS, EFGARTIGIMOD ALFA, SEOCALCITOL, ROZANOLIXIZUMAB, VERNAKALANT, PEFCALCITOL, VERNAKALANT HYDROCHLORIDE, LUNACALCIPOL, PIMECROLIMUS, DP001, ALFACALCIDOL |
| CMF-34705 | CYP4F12 | up-regulates | hsa-mir-93 | represses | R-397 | 44 | 14 | Drugs (16) Regulator Drugs (0)Regulon Drugs (16)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-34706 | CYP4F12 | up-regulates | hsa-mir-93 | represses | R-419 | 44 | 14 | Drugs (2) |
| CMF-34707 | CYP4F12 | up-regulates | hsa-mir-93 | represses | R-2477 | 44 | 14 | Drugs (2) |
| CMF-34708 | CYP4F12 | up-regulates | hsa-mir-93 | represses | R-2585 | 44 | 14 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-34709 | CYP4F12 | up-regulates | hsa-mir-93 | represses | R-2885 | 44 | 14 | Drugs (1) |
| CMF-34710 | CYP4F12 | up-regulates | hsa-mir-93 | represses | R-3134 | 44 | 14 | Drugs (1) |
| CMF-34711 | CYP4F12 | up-regulates | hsa-mir-93 | represses | R-3348 | 44 | 14 | Drugs (1) |
| CMF-34712 | CYP4F12 | up-regulates | hsa-mir-93 | represses | R-1592 | 44 | 14 | Drugs (17) Regulator Drugs (0)Regulon Drugs (17)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, BRENSOCATIB, ELDECALCITOL, CALCIPOTRIENE, EMRICASAN, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-34713 | CYP4F12 | up-regulates | hsa-mir-93 | represses | R-1679 | 44 | 14 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-34714 | CYP4F12 | up-regulates | hsa-mir-93 | represses | R-1829 | 44 | 14 | Drugs (2) |