Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

TCF3 - transcription factor 3

Function

Isoform E47Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity.

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
6929 ENSG00000071564 TCF3 P15923

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000071564 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-00675HMCN1up-regulatesTCF3activatesR-1590183Drugs (92)

Regulator Drugs (0)

Regulon Drugs (92)

PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, OLECLUMAB, HYDROXYZINE, LORATADINE, LY2624803, BELZUTIFAN, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, OCRIPLASMIN, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE

CMF-00677HMCN1up-regulatesTCF3activatesR-1597183Drugs (20)
CMF-01833TMPRSS15up-regulatesTCF3activatesR-1590185Drugs (92)

Regulator Drugs (0)

Regulon Drugs (92)

PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, OLECLUMAB, HYDROXYZINE, LORATADINE, LY2624803, BELZUTIFAN, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, OCRIPLASMIN, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE

CMF-01835TMPRSS15up-regulatesTCF3activatesR-1597185Drugs (20)
CMF-01898CYP4F8up-regulatesTCF3activatesR-1590182Drugs (92)

Regulator Drugs (0)

Regulon Drugs (92)

PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, OLECLUMAB, HYDROXYZINE, LORATADINE, LY2624803, BELZUTIFAN, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, OCRIPLASMIN, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE

CMF-02198OR4N2up-regulatesTCF3repressesR-1598182Drugs (52)
CMF-02832MST1up-regulatesTCF3activatesR-1597182Drugs (20)
CMF-03171WDR90up-regulatesTCF3repressesR-1598183Drugs (52)
CMF-03172WDR90up-regulatesTCF3repressesR-1592183Drugs (17)
CMF-04640CYP4F12up-regulatesTCF3repressesR-1592182Drugs (17)
CMF-06087FGFR3down-regulatesTCF3repressesR-1592183Drugs (17)
CMF-06224GABRB2down-regulatesTCF3activatesR-1600183Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-06297AFF2up-regulatesTCF3repressesR-1598185Drugs (52)
CMF-07576AHNAK2up-regulatesTCF3repressesR-1598185Drugs (52)
CMF-07577AHNAK2up-regulatesTCF3repressesR-1592185Drugs (17)
CMF-07840TNK2up-regulatesTCF3repressesR-1592181Drugs (17)
CMF-08164UNC93Adown-regulatesTCF3repressesR-1592182Drugs (17)
CMF-10081ATP8A2up-regulatesTCF3repressesR-1592183Drugs (17)
CMF-11163ODF4up-regulatesTCF3activatesR-1597181Drugs (20)
CMF-11669AHRup-regulatesTCF3activatesR-1590184Drugs (92)

Regulator Drugs (0)

Regulon Drugs (92)

PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, OLECLUMAB, HYDROXYZINE, LORATADINE, LY2624803, BELZUTIFAN, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, OCRIPLASMIN, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE

CMF-11671AHRup-regulatesTCF3activatesR-1597184Drugs (20)
CMF-11925SPAM1up-regulatesTCF3activatesR-1597182Drugs (20)
CMF-14531GPR112up-regulatesTCF3activatesR-1590183Drugs (92)

Regulator Drugs (0)

Regulon Drugs (92)

PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, OLECLUMAB, HYDROXYZINE, LORATADINE, LY2624803, BELZUTIFAN, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, OCRIPLASMIN, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE

CMF-14532GPR112up-regulatesTCF3activatesR-1597183Drugs (20)
CMF-14702PTPN11down-regulatesTCF3activatesR-1601182Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-15530PIK3R1up-regulatesTCF3activatesR-1604182Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

BRICICLIB, THYROTROPIN, PALBOCICLIB, THYROTROPIN ALFA

CMF-15584SASH1down-regulatesTCF3repressesR-1598183Drugs (52)
CMF-16079NFIXdown-regulatesTCF3repressesR-1592184Drugs (17)
CMF-17660DOCK5up-regulatesTCF3repressesR-1598182Drugs (52)
CMF-20762TLR7up-regulatesTCF3activatesR-1600182Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-22028WNT2up-regulatesTCF3repressesR-1598182Drugs (52)
CMF-22029WNT2up-regulatesTCF3activatesR-1597182Drugs (20)
CMF-22743IDH1up-regulatesTCF3activatesR-1601187Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-22744IDH1up-regulatesTCF3activatesR-1600187Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-22745IDH1up-regulatesTCF3repressesR-1592187Drugs (17)
CMF-22746IDH1up-regulatesTCF3activatesR-1604187Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

BRICICLIB, THYROTROPIN, PALBOCICLIB, THYROTROPIN ALFA

CMF-23471OR8H3up-regulatesTCF3activatesR-1600183Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-23959TP53up-regulatesTCF3activatesR-1601188Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-23960TP53up-regulatesTCF3activatesR-1600188Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-23961TP53up-regulatesTCF3repressesR-1592188Drugs (17)
CMF-23962TP53up-regulatesTCF3activatesR-1604188Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

BRICICLIB, THYROTROPIN, PALBOCICLIB, THYROTROPIN ALFA

CMF-26151MST1P9up-regulatesTCF3activatesR-1600183Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-26871VAV1up-regulatesTCF3activatesR-1590183Drugs (92)

Regulator Drugs (0)

Regulon Drugs (92)

PROMETHAZINE HYDROCHLORIDE, TRIPROLIDINE, LEVOCETIRIZINE DIHYDROCHLORIDE, KETOTIFEN FUMARATE, PYRILAMINE MALEATE, TRIPELENNAMINE, RUPATADINE, DOXYLAMINE SUCCINATE, MECLIZINE, BEPOTASTINE, BROMPHENIRAMINE, CLEMASTINE, OLOPATADINE HYDROCHLORIDE, CYPROHEPTADINE HYDROCHLORIDE, EPINASTINE HYDROCHLORIDE, TERFENADINE, CARBINOXAMINE MALEATE, DEXCHLORPHENIRAMINE, ORPHENADRINE HYDROCHLORIDE, CHLORPHENIRAMINE MALEATE, IMSIDOLIMAB, DEXBROMPHENIRAMINE, OLOPATADINE, ASTEMIZOLE, CHLORPHENIRAMINE, HISTAMINE, LEVOCABASTINE, DEXBROMPHENIRAMINE MALEATE, EBASTINE, CINNARIZINE, OLECLUMAB, HYDROXYZINE, LORATADINE, LY2624803, BELZUTIFAN, PHENIRAMINE MALEATE, TRIPROLIDINE HYDROCHLORIDE, DIPHENHYDRAMINE HYDROCHLORIDE, TRIMIPRAMINE, BUCLIZINE, EPINASTINE, ORPHENADRINE, KETOTIFEN, FEXOFENADINE, BILASTINE, CHLORPHENOXAMINE, LEVOCABASTINE HYDROCHLORIDE, DIBENZEPIN, PROMETHAZINE, AZELASTINE, DIPHENHYDRAMINE CITRATE, TOLAZOLINE, METHYLPROMAZINE, AZELASTINE HYDROCHLORIDE, ANTAZOLINE, CYCLIZINE, FEXOFENADINE HYDROCHLORIDE, DOXYLAMINE, CETIRIZINE HYDROCHLORIDE, DIPHENYLPYRALINE, ESMIRTAZAPINE MALEATE, LEVOCETIRIZINE, ACRIVASTINE, BEPOTASTINE BESYLATE, DIPHENHYDRAMINE, THENALIDINE, DIMENHYDRINATE, GSK-1004723, PYRILAMINE, ORPHENADRINE CITRATE, DEXCHLORPHENIRAMINE MALEATE, CYPROHEPTADINE, PHENIRAMINE, CLEMASTINE FUMARATE, OCRIPLASMIN, BROMODIPHENHYDRAMINE, DIMETHINDENE, AZATADINE, ESMIRTAZAPINE, BROMPHENIRAMINE MALEATE, MECLIZINE HYDROCHLORIDE, METHAPYRILENE, EMEDASTINE, MIZOLASTINE, HYDROXYZINE PAMOATE, ALCAFTADINE, BETAHISTINE, CARBINOXAMINE, DESLORATADINE, CETIRIZINE, SPESOLIMAB, METHDILAZINE

CMF-29682ESRRBdown-regulatesTCF3repressesR-1592186Drugs (17)
CMF-30108MTUS2up-regulatesTCF3activatesR-1597184Drugs (20)
CMF-31154LRFN2up-regulatesTCF3activatesR-1600187Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN

CMF-31155LRFN2up-regulatesTCF3repressesR-1592187Drugs (17)