Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows regulated by Mutation A6B1_AND_A6B4_INTEGRIN_SIGNALING_PID_NCI_NATURE_nonsilent_somatic

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-32061A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesIRF2activatesR-4172510Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

TOSEDOSTAT

CMF-32062A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesIRF2activatesR-4262510Drugs (11)
CMF-32064A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesIRF2activatesR-4182510Drugs (4)
CMF-32065A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesIRF2activatesR-4242510Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

IMPLITAPIDE, LOMITAPIDE MESYLATE, LOMITAPIDE, SLX-4090

CMF-32072A6B1_AND_A6B4_INTEGRIN_SIGNALINGdown-regulatesNR1H4repressesR-234461Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN

CMF-32073A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesSREBF1activatesR-2507123Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

TOSEDOSTAT

CMF-32075A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesSREBF1activatesR-2498123Drugs (5)

Regulator Drugs (0)

Regulon Drugs (5)

ATN-161, NATALIZUMAB, FIRATEGRAST, VOLOCIXIMAB, ABITUZUMAB

CMF-32076A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesMAFactivatesR-185196Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

DANVATIRSEN

CMF-32077A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesMAFactivatesR-180196Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

BI-505, OBATOCLAX MESYLATE, OBATOCLAX, AVDORALIMAB, AVACOPAN, ALICAFORSEN

CMF-32078A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesMAFactivatesR-184196Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-32089A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesTEAD3activatesR-2100155Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, PEGINTERFERON LAMBDA-1A

CMF-32090A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesTEAD3activatesR-2107155Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN

CMF-32091A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesTEAD3activatesR-2105155Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

ENIBARCIMAB, PROBUCOL

CMF-32092A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesTEAD3activatesR-2101155Drugs (11)
CMF-32097A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesMEOX2activatesR-2196144Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

OCRIPLASMIN

CMF-32100A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesMEOX2activatesR-2199144Drugs (59)
CMF-32105A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesSTAT5AactivatesR-2950216Drugs (3)

Regulator Drugs (0)

Regulon Drugs (3)

IMSIDOLIMAB, OCRIPLASMIN, SPESOLIMAB

CMF-32106A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesSTAT5AactivatesR-2940216Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-32108A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesSTAT5AactivatesR-2945216Drugs (7)
CMF-32109A6B1_AND_A6B4_INTEGRIN_SIGNALINGdown-regulatesEMX1repressesR-3049142Drugs (59)
CMF-32115A6B1_AND_A6B4_INTEGRIN_SIGNALINGdown-regulatesHOXB13repressesR-3240153Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BENFLUOREX, NEVANIMIBE

CMF-32117A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesLMO2activatesR-20343Drugs (49)
CMF-32118A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesLMO2activatesR-20643Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-32119A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesSP1activatesR-137681Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-32124A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesCEBPAactivatesR-2596217Drugs (6)

Regulator Drugs (0)

Regulon Drugs (6)

EDASALONEXENT, L19IL2, AS-1409, L19TNFA, L19SIP 131I, OCRIPLASMIN

CMF-32125A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesCEBPAactivatesR-2587217Drugs (7)
CMF-32127A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesCEBPAactivatesR-2589217Drugs (10)
CMF-32129A6B1_AND_A6B4_INTEGRIN_SIGNALINGdown-regulatesTEFrepressesR-2660153Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

EMRICASAN

CMF-32130A6B1_AND_A6B4_INTEGRIN_SIGNALINGdown-regulatesTEFrepressesR-2656153Drugs (4)

Regulator Drugs (0)

Regulon Drugs (4)

BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, FRESOLIMUMAB

CMF-32131A6B1_AND_A6B4_INTEGRIN_SIGNALINGdown-regulatesTEFrepressesR-2659153Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BENFLUOREX, NEVANIMIBE

CMF-32132A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesSP3activatesR-3423124Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-32138A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesMAXactivatesR-3501183Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

BENFLUOREX, NEVANIMIBE

CMF-32140A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesMZF1activatesR-1013162Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

OCRIPLASMIN

CMF-32141A6B1_AND_A6B4_INTEGRIN_SIGNALINGdown-regulatesPOU6F2repressesR-2616122Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

OCRIPLASMIN