Gene details
Summary of gene annotations and link-out to annotation databases
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
IL10RB - interleukin 10 receptor subunit beta
Function
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 3588 | ENSG00000243646 | IL10RB | Q08334 |
Gene Regulons
List of regulons containing the gene.
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-1068 | Pr-0 | 1 | 1 | 4 |
| R-114 | Pr-0 | 1 | 1 | 12 |
| R-1300 | Pr-0 | 1 | 1 | 25 |
| R-1356 | Pr-0 | 1 | 1 | 4 |
| R-138 | Pr-0 | 1 | 1 | 7 |
| R-1517 | Pr-0 | 1 | 1 | 10 |
| R-1550 | Pr-0 | 1 | 1 | 3 |
| R-1676 | Pr-0 | 1 | 1 | 13 |
| R-1904 | Pr-0 | 1 | 1 | 9 |
| R-2100 | Pr-0 | 1 | 1 | 12 |
| R-2113 | Pr-0 | 1 | 1 | 5 |
| R-2348 | Pr-0 | 1 | 1 | 9 |
| R-2452 | Pr-0 | 1 | 1 | 3 |
| R-2539 | Pr-0 | 1 | 1 | 2 |
| R-2589 | Pr-0 | 1 | 1 | 4 |
| R-2687 | Pr-0 | 1 | 1 | 14 |
| R-276 | Pr-0 | 1 | 1 | 13 |
| R-2863 | Pr-0 | 1 | 1 | 2 |
| R-3073 | Pr-0 | 1 | 1 | 10 |
| R-3096 | Pr-133 | 1 | 1 | 9 |
| R-3103 | Pr-0 | 1 | 1 | 9 |
| R-3120 | Pr-0 | 1 | 1 | 8 |
| R-3127 | Pr-0 | 1 | 1 | 7 |
| R-3156 | Pr-0 | 1 | 1 | 5 |
| R-375 | Pr-0 | 1 | 1 | 9 |
| R-418 | Pr-0 | 1 | 1 | 12 |
| R-445 | Pr-0 | 1 | 1 | 15 |
| R-648 | Pr-0 | 1 | 1 | 7 |