Regulon

Regulon: R-3127

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
212.8551617Pr-0Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
9168 ENSG00000034510 TMSB10 P63313
841 ENSG00000064012 CASP8 Q14790
29957 ENSG00000085491 SLC25A24 Q6NUK1
7076 ENSG00000102265 TIMP1 Q6FGX5
27286 ENSG00000102359 SRPX2 O60687
2184 ENSG00000103876 FAH P16930
10312 ENSG00000110719 TCIRG1 Q13488
6237 ENSG00000126458 RRAS P10301
813 ENSG00000128595 CALU O43852
3597 ENSG00000131724 IL13RA1 P78552
8763 ENSG00000135535 CD164 Q04900
4060 ENSG00000139329 LUM P51884
3688 ENSG00000150093 ITGB1 P05556
831 ENSG00000153113 CAST P20810
302 ENSG00000182718 ANXA2 P07355
307 ENSG00000196975 ANXA4 Q6P452
375035 ENSG00000213064 SFT2D2 O95562
81567 ENSG00000239264 TXNDC5 Q8NBS9
3588 ENSG00000243646 IL10RB Q08334
3460 ENSG00000262795 IFNGR2 P38484
123803 ENSG00000275779 NTAN1 H3BNJ5

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
ATN-161ITGB3ProteinANTAGONISTIntegrin alpha-5/beta-1 antagonist20
CINTREDEKIN BESUDOTOXIL4RProteinBINDING AGENTInterleukin 13 receptor binding agent33
NIVOCASANCASP1Small moleculeINHIBITORCaspase-9 inhibitor20
NATALIZUMABITGA4AntibodyINHIBITORIntegrin alpha-4/beta-1 inhibitor40
FIRATEGRASTITGB1Small moleculeANTAGONISTIntegrin alpha-4/beta-1 antagonist20
EMRICASANCASP4Small moleculeINHIBITORCaspase inhibitor20
VOLOCIXIMABITGB1AntibodyANTAGONISTIntegrin alpha-5/beta-1 antagonist30
PEGINTERFERON LAMBDA-1AIL10RBProteinAGONISTInterferon lambda receptor agonist30
ABITUZUMABITGAVAntibodyINHIBITORIntegrin alpha-V/beta-5 inhibitor20

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-3127

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-05342AMAC1down-regulatesCDX1activatesR-312771Drugs (9)
CMF-05749ADAMTS19down-regulatesCDX1activatesR-312772Drugs (9)
CMF-15138YEATS2down-regulatesCDX1activatesR-312774Drugs (9)
CMF-16168USP11down-regulatesCDX1activatesR-312772Drugs (9)
CMF-19048ST6GAL2down-regulatesCDX1activatesR-312774Drugs (9)
CMF-28049CELSR3down-regulatesCDX1activatesR-312774Drugs (9)
CMF-29383PTCHD3down-regulatesCDX1activatesR-312772Drugs (9)