Gene details
Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
IFI30 - IFI30 lysosomal thiol reductase
Function
Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 10437 | ENSG00000216490 | IFI30 | P13284 |
Gene Regulons
A gene can be associated with multiple causal flows as a member of multiple regulons
| Regulon | Program | # genes | # regulators | # causal flows |
|---|---|---|---|---|
| R-117 | Pr-4 | 1 | 1 | 99 |
| R-1518 | Pr-4 | 1 | 1 | 7 |
| R-1592 | Pr-4 | 1 | 1 | 87 |
| R-1608 | Pr-4 | 1 | 1 | 8 |
| R-1679 | Pr-4 | 1 | 1 | 92 |
| R-2161 | Pr-4 | 1 | 1 | 71 |
| R-2456 | Pr-4 | 1 | 1 | 3 |
| R-2477 | Pr-4 | 1 | 1 | 77 |
| R-2767 | Pr-4 | 1 | 1 | 70 |
| R-2885 | Pr-4 | 1 | 1 | 81 |
| R-2943 | Pr-4 | 1 | 1 | 14 |
| R-3126 | Pr-4 | 1 | 1 | 11 |
| R-3134 | Pr-4 | 1 | 1 | 97 |
| R-3345 | Pr-4 | 1 | 1 | 2 |
| R-3377 | Pr-4 | 1 | 1 | 7 |
| R-371 | Pr-4 | 1 | 1 | 74 |
| R-397 | Pr-4 | 1 | 1 | 107 |
| R-419 | Pr-4 | 1 | 1 | 90 |
| R-449 | Pr-4 | 1 | 1 | 10 |
| R-737 | Pr-4 | 1 | 1 | 72 |