Regulon

Regulon: R-117

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
262.58511199Pr-4Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
5329 ENSG00000011422 PLAUR Q03405
1992 ENSG00000021355 SERPINB1 P30740
2896 ENSG00000030582 GRN P28799
2769 ENSG00000060558 GNA15 K7EP74
55843 ENSG00000075884 ARHGAP15 Q53QZ3
7421 ENSG00000111424 VDR F1D8P8
50856 ENSG00000111729 CLEC4A Q9UMR7
59342 ENSG00000121064 SCPEP1 I3L2N6
1475 ENSG00000121552 CSTA P01040
5880 ENSG00000128340 RAC2 P15153
10095 ENSG00000130429 ARPC1B O15143
3936 ENSG00000136167 LCP1 P13796
58472 ENSG00000137767 SQRDL Q9Y6N5
8804 ENSG00000143162 CREG1 A0A3B3IRL2
25816 ENSG00000145779 TNFAIP8 O95379
9056 ENSG00000155465 SLC7A7 Q9UM01
5603 ENSG00000156711 MAPK13 A0A024RD04
56833 ENSG00000158714 SLAMF8 Q9P0V8
6282 ENSG00000163191 S100A11 P31949
1508 ENSG00000164733 CTSB E9PSG5
399 ENSG00000168421 RHOH Q15669
64581 ENSG00000172243 CLEC7A Q9BXN2
837 ENSG00000196954 CASP4 P49662
10437 ENSG00000216490 IFI30 P13284
240 ENSG00000275565 ALOX5 P09917
5265 ENSG00000277377 SERPINA1 P01009

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
CALCIFEDIOLVDRSmall moleculeAGONISTVitamin D receptor agonist40
BECOCALCIDIOLVDRSmall moleculeAGONISTVitamin D receptor agonist20
PARICALCITOLVDRSmall moleculeAGONISTVitamin D receptor agonist40
INECALCITOLVDRSmall moleculeAGONISTVitamin D receptor agonist20
ERGOCALCIFEROLVDRSmall moleculeAGONISTVitamin D receptor agonist40
CHOLECALCIFEROLVDRSmall moleculeAGONISTVitamin D receptor agonist41
DOXERCALCIFEROLVDRSmall moleculeAGONISTVitamin D receptor agonist40
CALCITRIOLVDRSmall moleculeAGONISTVitamin D receptor agonist40
ELDECALCITOLVDRSmall moleculeAGONISTVitamin D receptor agonist30
CALCIPOTRIENEVDRSmall moleculeAGONISTVitamin D receptor agonist40
EMRICASANCASP4Small moleculeINHIBITORCaspase inhibitor20
SEOCALCITOLVDRSmall moleculeAGONISTVitamin D receptor agonist30
PEFCALCITOLVDRSmall moleculeAGONISTVitamin D receptor agonist30
LUNACALCIPOLVDRSmall moleculeAGONISTVitamin D receptor agonist20
DP001VDRSmall moleculeAGONISTVitamin D receptor agonist20
ALFACALCIDOLVDRSmall moleculeAGONISTVitamin D receptor agonist40

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-117

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-00586HMCN1up-regulatesIRF1activatesR-117256Drugs (16)
CMF-04225RBPJLup-regulatesIRF1activatesR-1172510Drugs (16)
CMF-06856ATRXdown-regulatesIRF1activatesR-1172513Drugs (16)
CMF-12668WDFY3up-regulatesIRF1activatesR-117253Drugs (16)
CMF-14464ANKRD33up-regulatesIRF1activatesR-117254Drugs (16)
CMF-17001FLNAdown-regulatesIRF1activatesR-117254Drugs (16)
CMF-18877INPP5Jdown-regulatesIRF1activatesR-117256Drugs (16)
CMF-21649MUC17up-regulatesIRF1activatesR-1172512Drugs (16)
CMF-22502IDH1down-regulatesIRF1activatesR-1172514Drugs (16)
CMF-23757TP53down-regulatesIRF1activatesR-1172514Drugs (16)
CMF-25032IQSEC3down-regulatesIRF1activatesR-117256Drugs (16)
CMF-25822CD163down-regulatesIRF1activatesR-117253Drugs (16)
CMF-27607ANKRD36up-regulatesIRF1activatesR-117256Drugs (16)
CMF-33949MCM6down-regulateshsa-mir-139repressesR-1175834Drugs (16)
CMF-33989MCM6down-regulateshsa-mir-129repressesR-11715576Drugs (16)
CMF-34091TMEM146down-regulateshsa-mir-454-3prepressesR-1173112Drugs (16)
CMF-34361SPEF2up-regulateshsa-mir-20brepressesR-117443Drugs (16)
CMF-34394WDR90up-regulateshsa-mir-106brepressesR-117216Drugs (16)
CMF-34401WDR90up-regulateshsa-mir-93repressesR-1174416Drugs (16)
CMF-34585MYH8down-regulateshsa-mir-346repressesR-1172014Drugs (16)
CMF-34614MYH8down-regulateshsa-mir-129repressesR-11715550Drugs (16)
CMF-34702CYP4F12up-regulateshsa-mir-93repressesR-1174414Drugs (16)
CMF-34916KIAA1549down-regulateshsa-mir-346repressesR-1172013Drugs (16)
CMF-34977SIRPGdown-regulateshsa-mir-346repressesR-1172018Drugs (16)
CMF-35027FGFR3down-regulateshsa-mir-346repressesR-1172016Drugs (16)
CMF-35045FGFR3down-regulateshsa-mir-454-3prepressesR-1173129Drugs (16)
CMF-35077FGFR3down-regulateshsa-mir-20brepressesR-1174426Drugs (16)
CMF-35200ATRXup-regulateshsa-mir-139repressesR-1175858Drugs (16)
CMF-35270ATRXup-regulateshsa-mir-454-3prepressesR-1173122Drugs (16)
CMF-35473ATRXup-regulateshsa-mir-106brepressesR-1172112Drugs (16)
CMF-35486ATRXup-regulateshsa-mir-17-3prepressesR-1175231Drugs (16)
CMF-35518ATRXup-regulateshsa-mir-93repressesR-1174435Drugs (16)
CMF-35704ATRXup-regulateshsa-mir-20brepressesR-1174435Drugs (16)
CMF-35968AHNAK2up-regulateshsa-mir-106brepressesR-1172116Drugs (16)
CMF-35990AHNAK2up-regulateshsa-mir-93repressesR-1174426Drugs (16)
CMF-36018AHNAK2up-regulateshsa-mir-20brepressesR-1174426Drugs (16)
CMF-36064DPPA4down-regulateshsa-mir-93repressesR-1174422Drugs (16)
CMF-36139TNK2up-regulateshsa-mir-17-3prepressesR-1175240Drugs (16)
CMF-36684ATP8A2up-regulateshsa-mir-454-3prepressesR-1173127Drugs (16)
CMF-36715ATP8A2up-regulateshsa-mir-17-3prepressesR-1175240Drugs (16)
CMF-36753ATP8A2up-regulateshsa-mir-93repressesR-1174432Drugs (16)
CMF-36787ATP8A2up-regulateshsa-mir-20brepressesR-1174431Drugs (16)
CMF-37197CYP4F22down-regulateshsa-mir-129repressesR-11715535Drugs (16)
CMF-37382WDFY3down-regulateshsa-mir-106brepressesR-117217Drugs (16)
CMF-37682ADAMTS8up-regulateshsa-mir-17-3prepressesR-1175240Drugs (16)
CMF-37811ANKRD33down-regulateshsa-mir-106brepressesR-117215Drugs (16)
CMF-37816ANKRD33down-regulateshsa-mir-93repressesR-1174425Drugs (16)
CMF-37935SLC5A12down-regulateshsa-mir-17-3prepressesR-1175213Drugs (16)
CMF-38008PPEF2down-regulateshsa-mir-346repressesR-1172016Drugs (16)
CMF-38056FAM110Bup-regulateshsa-mir-139repressesR-117588Drugs (16)
CMF-38081OR51F1up-regulateshsa-mir-106brepressesR-1172117Drugs (16)
CMF-38099OR51F1up-regulateshsa-mir-93repressesR-1174435Drugs (16)
CMF-38316ZNF845up-regulateshsa-mir-454-3prepressesR-1173127Drugs (16)
CMF-38420KCNB2down-regulateshsa-mir-106brepressesR-1172115Drugs (16)
CMF-38437KCNB2down-regulateshsa-mir-17-3prepressesR-1175236Drugs (16)
CMF-38472KCNB2down-regulateshsa-mir-93repressesR-1174427Drugs (16)
CMF-38498NFIXdown-regulateshsa-mir-346repressesR-1172017Drugs (16)
CMF-38560CPNE8down-regulateshsa-mir-17-3prepressesR-1175228Drugs (16)
CMF-38586CPNE8down-regulateshsa-mir-93repressesR-1174420Drugs (16)
CMF-38768FLNAup-regulateshsa-mir-106brepressesR-117217Drugs (16)
CMF-38981SGIP1down-regulateshsa-mir-17-3prepressesR-1175226Drugs (16)
CMF-39008SGIP1down-regulateshsa-mir-93repressesR-1174423Drugs (16)
CMF-39031SGIP1down-regulateshsa-mir-20brepressesR-1174423Drugs (16)
CMF-39335DENND1Cup-regulateshsa-mir-454-3prepressesR-117314Drugs (16)
CMF-39342DENND1Cup-regulateshsa-mir-20brepressesR-117442Drugs (16)
CMF-39346UPF1down-regulateshsa-mir-346repressesR-1172016Drugs (16)
CMF-39362UPF1down-regulateshsa-mir-139repressesR-1175813Drugs (16)
CMF-39553NF1down-regulateshsa-mir-106brepressesR-1172120Drugs (16)
CMF-39621NF1down-regulateshsa-mir-93repressesR-1174431Drugs (16)
CMF-39711NF1down-regulateshsa-mir-20brepressesR-1174431Drugs (16)
CMF-39757RPSAP58down-regulateshsa-mir-17-3prepressesR-1175240Drugs (16)
CMF-39798UGT2B4down-regulateshsa-mir-139repressesR-117589Drugs (16)
CMF-39813UGT2B4down-regulateshsa-mir-149repressesR-1175135Drugs (16)
CMF-39924TDRD9down-regulateshsa-mir-106brepressesR-1172121Drugs (16)
CMF-39948TDRD9down-regulateshsa-mir-17-3prepressesR-1175242Drugs (16)
CMF-40203KRTAP4-7down-regulateshsa-mir-17-3prepressesR-1175217Drugs (16)
CMF-40425IDH1up-regulateshsa-mir-346repressesR-1172020Drugs (16)
CMF-40444IDH1up-regulateshsa-mir-139repressesR-1175858Drugs (16)
CMF-40514IDH1up-regulateshsa-mir-454-3prepressesR-1173122Drugs (16)
CMF-40761IDH1up-regulateshsa-mir-106brepressesR-1172112Drugs (16)
CMF-40774IDH1up-regulateshsa-mir-17-3prepressesR-1175231Drugs (16)
CMF-40808IDH1up-regulateshsa-mir-93repressesR-1174435Drugs (16)
CMF-40994IDH1up-regulateshsa-mir-20brepressesR-1174435Drugs (16)
CMF-41223TP53up-regulateshsa-mir-346repressesR-1172020Drugs (16)
CMF-41319TP53up-regulateshsa-mir-17-3prepressesR-1175252Drugs (16)
CMF-41370TP53up-regulateshsa-mir-93repressesR-1174444Drugs (16)
CMF-41531TP53up-regulateshsa-mir-20brepressesR-1174444Drugs (16)
CMF-41573WBSCR17down-regulateshsa-mir-17-3prepressesR-1175212Drugs (16)
CMF-41772IQSEC3up-regulateshsa-mir-454-3prepressesR-1173125Drugs (16)
CMF-41900IQSEC3up-regulateshsa-mir-20brepressesR-1174434Drugs (16)
CMF-42010CD163up-regulateshsa-mir-149repressesR-1175116Drugs (16)
CMF-42144NAALADL1down-regulateshsa-mir-346repressesR-1172018Drugs (16)
CMF-42167NAALADL1down-regulateshsa-mir-139repressesR-1175814Drugs (16)
CMF-42286MVPup-regulateshsa-mir-17-3prepressesR-1175212Drugs (16)
CMF-42326SDK1down-regulateshsa-mir-346repressesR-1172014Drugs (16)
CMF-42361SDK1down-regulateshsa-mir-129repressesR-11715522Drugs (16)
CMF-42464FSTL5down-regulateshsa-mir-17-3prepressesR-1175216Drugs (16)
CMF-42745AQP10up-regulateshsa-mir-129repressesR-11715541Drugs (16)
CMF-43183PRKDCdown-regulateshsa-mir-346repressesR-1172016Drugs (16)