Regulon

Regulon: R-708

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
13-2.1504518Pr-110Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
10129 ENSG00000073910 FRY Q5TBA9
8648 ENSG00000084676 NCOA1 Q15788
3983 ENSG00000099204 ABLIM1 O14639
22852 ENSG00000107890 ANKRD26 Q9UPS8
7915 ENSG00000112294 ALDH5A1 P51649
7067 ENSG00000126351 THRA P10827
7014 ENSG00000132604 TERF2 Q15554
5295 ENSG00000145675 PIK3R1 P27986
51560 ENSG00000154917 RAB6B Q9NRW1
26050 ENSG00000165300 SLITRK5 O94991
2066 ENSG00000178568 ERBB4 Q15303
9722 ENSG00000198929 NOS1AP O75052
23026 ENSG00000282848 MYO16

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase
PF-04691502PIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
POZIOTINIBERBB2Small moleculeINHIBITOREpidermal growth factor receptor inhibitor20
DEXTROTHYROXINETHRASmall moleculeAGONISTThyroid hormone receptor agonist40
BGT-226PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
SONOLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor22
VOXTALISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor21
CANERTINIB DIHYDROCHLORIDEERBB4Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor30
NERATINIB MALEATEERBB2Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-4 inhibitor40
APITOLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
DS-7423PIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor10
NERATINIBERBB2Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor42
BMS-690514KDRSmall moleculeINHIBITOREpidermal growth factor receptor erbB1 inhibitor20
AC-480ERBB2Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor10
PAXALISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor22
PICTILISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
LIOTHYRONINETHRASmall moleculeAGONISTThyroid hormone receptor agonist40
DEXTROTHYROXINE SODIUMTHRASmall moleculeAGONISTThyroid hormone receptor agonist40
DACOMITINIBEGFRSmall moleculeINHIBITORReceptor protein-tyrosine kinase erbB-4 inhibitor42
KBP5209ERBB2UnknownINHIBITOREpidermal growth factor receptor inhibitor10
TARLOXOTINIBERBB2Small moleculeINHIBITOREpidermal growth factor receptor inhibitor20
VS-5584PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
VALPROIC ACIDALDH5A1Small moleculeINHIBITORSuccinate semialdehyde dehydrogenase inhibitor42
SAMOTOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
VANDETANIBEPHA2Small moleculeINHIBITORTyrosine-protein kinase SRC inhibitor42
DACTOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor30
DIVALPROEX SODIUMALDH5A1Small moleculeINHIBITORSuccinate semialdehyde dehydrogenase inhibitor40
GNF-Pf-5468PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
WX-037PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
CANERTINIBERBB4Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor30
PILARALISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor21
TASELISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor30
JNJ-26483327ERBB2Small moleculeINHIBITORTyrosine-protein kinase FYN inhibitor10
LEVOTHYROXINE SODIUMTHRASmall moleculeAGONISTThyroid hormone receptor agonist40
GEDATOLISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor20
OMIPALISIBPIK3R1Small moleculeINHIBITORSerine/threonine-protein kinase mTOR inhibitor10
AFATINIB DIMALEATEEGFRSmall moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor40
AFATINIBERBB2Small moleculeINHIBITORReceptor protein-tyrosine kinase erbB-2 inhibitor41
LIOTHYRONINE SODIUMTHRASmall moleculeAGONISTThyroid hormone receptor agonist40
VALPROATE SODIUMALDH5A1Small moleculeINHIBITORSuccinate semialdehyde dehydrogenase inhibitor41
LEVOTHYROXINETHRASmall moleculeAGONISTThyroid hormone receptor agonist40
PA-799PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
GSK-1059615PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor10
BUPARLISIBPIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor32
SF-1126PIK3R1Small moleculeINHIBITORPI3-kinase class I inhibitor20
PANULISIBACVRL1Small moleculeINHIBITORSerine/threonine-protein kinase receptor R3 inhibitor10

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-708

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-01680SLCO5A1down-regulatesFOXO1activatesR-708212Drugs (45)
CMF-02461DNAH9up-regulatesFOXO1activatesR-708213Drugs (45)
CMF-06468LGSNup-regulatesFOXO1activatesR-708212Drugs (45)
CMF-14225SEC23Bup-regulatesFOXO1activatesR-708211Drugs (45)
CMF-24456SEMA3Cdown-regulatesFOXO1activatesR-7082110Drugs (45)
CMF-25499OR8K3up-regulatesFOXO1activatesR-708211Drugs (45)
CMF-29591ESRRBdown-regulatesFOXO1activatesR-708215Drugs (45)
CMF-29769SLC5A7up-regulatesFOXO1activatesR-708213Drugs (45)