Regulon

Regulon: R-2086

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramsHallmarks
63.0737817Pr-38Self sufficiency in growth signalInsensitivity to antigrowth signalEvading apoptosisSustained angiogenesisTissue invasion and metastasisTumor-promoting inflammationReprogramming energy metabolismEvading immune detectionLimitless replicative potentialGenome instability and mutation

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez IDEnsEMBL IDPreferred NameUniprot ID
28951 ENSG00000071575 TRIB2 Q92519
3842 ENSG00000083312 TNPO1 Q92973
2887 ENSG00000106070 GRB10 Q13322
10631 ENSG00000133110 POSTN Q15063
10253 ENSG00000136158 SPRY2 O43597
10252 ENSG00000164056 SPRY1 O43609

Regulon Drugs

NameApproved SymbolTypeAction TypeMechanism of ActionMax Trial PhaseMax GBM Phase

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-2086

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-01502MTORup-regulatesPRDM4activatesR-208683Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-07543ANO7down-regulatesPRDM4activatesR-208682Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-09527DOCK11up-regulatesPRDM4activatesR-208683Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-10083ATP8A2up-regulatesPRDM4activatesR-208682Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-12003KRTAP10-11up-regulatesPRDM4activatesR-208681Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-12515LAMB3up-regulatesPRDM4activatesR-208681Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-21397GRIK3up-regulatesPRDM4activatesR-208683Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)