Regulon – gbmMINER Portal

Regulon: R-1377

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share.

Regulon Summary

Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

Genes	Cox Hazard Ratio	Regulators	Causal Flows	Transcriptional Programs	Hallmarks
15	2.86306	0	0	Pr-108

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
23154	ENSG00000020129	NCDN	Q9UBB6
5141	ENSG00000065989	PDE4A	P27815
782	ENSG00000067191	CACNB1	Q02641
7301	ENSG00000092445	TYRO3	Q06418
6804	ENSG00000106089	STX1A	Q16623
10120	ENSG00000115073	ACTR1B	P42025
2185	ENSG00000120899	PTK2B	Q14289
9572	ENSG00000126368	NR1D1	F1D8S3
7277	ENSG00000127824	TUBA4A	P68366
3706	ENSG00000137825	ITPKA	P23677
57731	ENSG00000160460	SPTBN4	Q9H254
8941	ENSG00000171450	CDK5R2	Q13319
1212	ENSG00000175416	CLTB	P09497
5575	ENSG00000188191	PRKAR1B	P31321
50861	ENSG00000197457	STMN3	A0A0J9YXY4

Regulon Drugs

Name	Approved Symbol	Type	Action Type	Mechanism of Action	Max Trial Phase	Max GBM Phase
ERIBULIN MESYLATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
SAGOPILONE	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	2
AGS-16C3F	TUBB1	Unknown	DISRUPTING AGENT	Tubulin disrupting agent	2	0
TERODILINE	CACNA1D	Small molecule	BLOCKER	Voltage-gated calcium channel blocker	4	0
TELISOTUZUMAB VEDOTIN	MET	Antibody	BINDING AGENT	Hepatocyte growth factor receptor binding agent	3	0
DOCETAXEL	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
FOSBRETABULIN DISODIUM	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	2	0
CHF-6001	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
VINCRISTINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	3
VINFLUNINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
LEXIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	2	1
VINCRISTINE SULFATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	3
TRASTUZUMAB EMTANSINE	ERBB2	Antibody	INHIBITOR	Tubulin inhibitor	4	0
ENFORTUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Nectin-4 binding agent	4	0
VINORELBINE TARTRATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
LIFASTUZUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Sodium-dependent phosphate transport protein 2B binding agent	2	0
KOS-1584	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	0
APREMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	4	0
PRALUZATAMAB RAVTANSINE	ALCAM	Antibody	INHIBITOR	Tubulin inhibitor	2	0
DYPHYLLINE	PDE3A	Small molecule	INHIBITOR	Phosphodiesterase 3A inhibitor	4	0
OGLEMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
LADIRATUZUMAB VEDOTIN	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	2	0
FLAVOXATE HYDROCHLORIDE	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 8 inhibitor	4	0
PACLITAXEL	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	1
CROLIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	1	0
MK-0873	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
TOFIMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
PACLITAXEL POLIGLUMEX	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	0
PATUPILONE	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	1
PENTOXIFYLLINE	PDE4A	Small molecule	ANTAGONIST	Adenosine A2 receptor antagonist	4	0
ASG-5ME	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
ANG1005	LRP1	Protein	BINDING AGENT	Prolow-density lipoprotein receptor-related protein 1 binding agent	3	2
DROTAVERINE	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	3	0
PINATUZUMAB VEDOTIN	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
DIPYRIDAMOLE	SLC29A1	Small molecule	INHIBITOR	3',5'-cyclic phosphodiesterase inhibitor	4	0
VERUBULIN	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	2	2
VINBLASTINE SULFATE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
VINORELBINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	2
DEFACTINIB	PTK2B	Small molecule	INHIBITOR	Focal adhesion kinase 1 inhibitor	2	0
DAVUNETIDE	TUBB1	Protein	STABILISER	Tubulin stabiliser	2	0
BELANTAMAB MAFODOTIN	TUBB1	Antibody	BINDING AGENT	Tumor necrosis factor receptor superfamily member 17 binding agent	4	0
FOSBRETABULIN	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	3	0
IBUDILAST	PDE3A	Small molecule	INHIBITOR	Phosphodiesterase 3A inhibitor	3	1
MIRVETUXIMAB SORAVTANSINE	FOLR1	Antibody	INHIBITOR	Tubulin inhibitor	3	0
GSK-256066	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
ROFLUMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	4	0
IXABEPILONE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	1
POLATUZUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	B-cell antigen receptor complex-associated protein beta chain binding agent	4	0
T-900607	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	2	0
DIFAMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	3	0
APRUTUMAB IXADOTIN	TUBB1	Antibody	BINDING AGENT	Fibroblast growth factor receptor 2 binding agent	1	0
PLINABULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	3	0
GABAPENTIN ENACARBIL	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	4	0
TISOTUMAB VEDOTIN	F3	Antibody	BINDING AGENT	Coagulation factor III binding agent	4	0
DOLASTATIN-10	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	2	0
FOSBRETABULIN TROMETHAMINE	TUBB1	Small molecule	DISRUPTING AGENT	Tubulin disrupting agent	2	0
CILOMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	3	0
SAR-408701	TUBB1	Unknown	BINDING AGENT	Carcinoembryonic antigen-related cell adhesion molecule 5 binding agent	3	0
CABAZITAXEL	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	2
FLAVOXATE	PDE8B	Small molecule	INHIBITOR	Phosphodiesterase 8 inhibitor	4	0
PACLITAXEL DOCOSAHEXAENOIC ACID	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	0
PREGABALIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	4	0
ATAGABALIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	2	0
GABAPENTIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	4	0
ERIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
BMS-275183	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	0
INDUSATUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Heat-stable enterotoxin receptor binding agent	2	0
CRISABOROLE	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	4	0
GLEMBATUMUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Transmembrane glycoprotein NMB binding agent	2	0
COLCHICINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
VANDORTUZUMAB VEDOTIN	STEAP1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
VINBLASTINE	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	4	0
BEPRIDIL	CACNA1D	Small molecule	BLOCKER	Voltage-gated calcium channel blocker	4	0
BRENTUXIMAB VEDOTIN	TNFRSF8	Antibody	INHIBITOR	Tubulin inhibitor	4	0
SULOCTIDIL	CACNA1D	Small molecule	BLOCKER	Voltage-gated calcium channel blocker	4	0
IMAGABALIN	CACNA1D	Small molecule	MODULATOR	Voltage-gated calcium channel modulator	3	0
TETOMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	3	0
AMLEXANOX	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	4	0
EPOTHILONE D	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	2	0
SOFITUZUMAB VEDOTIN	TUBB1	Antibody	BINDING AGENT	Mucin-16 binding agent	1	0
INDIBULIN	TUBB1	Small molecule	INHIBITOR	Tubulin inhibitor	1	0
OXTRIPHYLLINE	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 3 inhibitor	4	0
AZINTUXIZUMAB VEDOTIN	TUBB1	Antibody	INHIBITOR	Tubulin inhibitor	1	0
HT-0712	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
LOTAMILAST	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
LAROTAXEL	TUBB1	Small molecule	STABILISER	Tubulin stabiliser	3	0
RG-7841	TUBB1	Unknown	INHIBITOR	Tubulin inhibitor	1	0
CC-11050	PDE4A	Small molecule	INHIBITOR	Phosphodiesterase 4 inhibitor	2	0
LORVOTUZUMAB MERTANSINE	NCAM1	Antibody	INHIBITOR	Tubulin inhibitor	2	0
THEOPHYLLINE	ADORA1	Small molecule	INHIBITOR	Phosphodiesterase 3 inhibitor	4	0
AMINOPHYLLINE	PDE3A	Small molecule	INHIBITOR	Phosphodiesterase 3 inhibitor	4	0
CONTELTINIB	PTK2	Small molecule	INHIBITOR	Protein tyrosine kinase 2 beta inhibitor	1	0

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulon R-1377

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs