Program Pr-61

Genes (44)

FOXN3, MLLT10, RSBN1, RPS6KA5, EYA1, STRN, KIAA0907, EPB41, NR1D2, RSRC1, PBX1, DAPK1, POLG2, SPAG9, ZFYVE16, TRIT1, PER3, CEP70, PTBP2, NAB1, NBPF3, RAD21, ZNF493, TSC22D2, SDCCAG8, FMR1, RBL2, KLHL24, EPB41L5, VPS13B, CBR4, LARS, RFX5, CASP8AP2, CRB1, RNF38, FBXO11, NFIB, ZBTB5, KLHL23, CEP170, MKRN3, DDX46, RRN3

Regulons (28)

R-163, R-577, R-736, R-1015, R-1240, R-1567, R-1666, R-1678, R-1693, R-1700, R-1752, R-1763, R-2208, R-2644, R-2764, R-2842, R-2909, R-3104, R-3279, R-3284, R-3287, R-3310, R-3315, R-3318, R-3321, R-3329, R-3338, R-3585

Regulons in program Pr-61

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-163	-2.30872	13	8
R-577	-2.05392	23	4
R-736	-2.08976	28	10
R-1015	-2.00474	10	2
R-1240	-2.21232	11	9
R-1567	-2.26	21	6
R-1666	-2.2908	8	3
R-1678	-1.99957	16	15
R-1693	-2.35954	6	17
R-1700	-1.89006	12	9
R-1752	-2.28381	8	2
R-1763	-2.93885	11	6
R-2208	-2.46145	16	12
R-2644	-2.04643	25	14
R-2764	-2.63335	7	22
R-2842	-2.06211	19	4
R-2909	-2.16646	13	2
R-3104	-2.18201	21	10
R-3279	-1.29268	10	2
R-3284	-1.1479	10	13
R-3287	-2.5475	14	7
R-3310	-2.44913	8	12
R-3315	-1.40825	8	10
R-3318	-2.98	8	6
R-3321	-2.00756	13	13
R-3329	-2.10842	20	5
R-3338	-2.81849	9	5
R-3585	-2.13201	5	8

Genes in program Pr-61

EnsEMBL Id	Entrez Id	Preferred
ENSG00000053254	1112	FOXN3
ENSG00000078403	8028	MLLT10
ENSG00000081019	54665	RSBN1
ENSG00000100784	9252	RPS6KA5
ENSG00000104313	2138	EYA1
ENSG00000115808	6801	STRN
ENSG00000132680	22889	KIAA0907
ENSG00000159023	2035	EPB41
ENSG00000174738	9975	NR1D2
ENSG00000174891	51319	RSRC1
ENSG00000185630	5087	PBX1
ENSG00000196730	1612	DAPK1
ENSG00000256525	11232	POLG2
ENSG00000008294	9043	SPAG9
ENSG00000039319	9765	ZFYVE16
ENSG00000043514	54802	TRIT1
ENSG00000049246	8863	PER3
ENSG00000114107	80321	CEP70
ENSG00000117569	58155	PTBP2
ENSG00000138386	4664	NAB1
ENSG00000142794	84224	NBPF3
ENSG00000164754	5885	RAD21
ENSG00000196268	284443	ZNF493
ENSG00000196428	9819	TSC22D2
ENSG00000276111	10806	SDCCAG8
ENSG00000102081	2332	FMR1
ENSG00000103479	5934	RBL2
ENSG00000114796	54800	KLHL24
ENSG00000115109	57669	EPB41L5
ENSG00000132549	157680	VPS13B
ENSG00000145439	84869	CBR4
ENSG00000133706	51520	LARS
ENSG00000143390	5993	RFX5
ENSG00000118412	9994	CASP8AP2
ENSG00000134376	23418	CRB1
ENSG00000137075	152006	RNF38
ENSG00000138081	80204	FBXO11
ENSG00000147862	4781	NFIB
ENSG00000168795	9925	ZBTB5
ENSG00000213160	151230	KLHL23
ENSG00000276725	9859	CEP170
ENSG00000179455	7681	MKRN3
ENSG00000145833	9879	DDX46
ENSG00000278494	54700	RRN3

Causal Mechanistic Flows with Program Pr-61

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-00333	COL6A3	up-regulates	HLX	represses	R-3585	10	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-00799	MUC2	down-regulates	SATB1	activates	R-1693	24	7	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-01428	MYO7B	down-regulates	POU4F1	activates	R-2764	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-01595	MCM6	down-regulates	SATB1	activates	R-1693	24	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-01684	SGOL2	down-regulates	SATB1	activates	R-1693	24	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-01709	SGOL2	up-regulates	FOXC2	represses	R-2644	11	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-02878	SRRM2	down-regulates	POU4F1	activates	R-2764	11	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-03375	ACRC	down-regulates	FOXC2	represses	R-2644	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-03574	RGS12	up-regulates	SATB1	activates	R-1693	24	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-03711	DSP	down-regulates	FOXD3	represses	R-577	25	15	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-03989	DSP	down-regulates	FOXC2	represses	R-2644	11	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-04080	OR4D5	down-regulates	POU4F1	activates	R-2764	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-04512	LAMC3	up-regulates	SATB1	activates	R-1693	24	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-04745	ADAMTS20	down-regulates	POU4F1	activates	R-2764	11	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05143	KCNH1	down-regulates	POU4F1	activates	R-2764	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05504	IL18RAP	down-regulates	POU3F1	represses	R-1666	25	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05549	IL18RAP	down-regulates	FOXC2	represses	R-2644	11	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05636	ITGB7	down-regulates	POU4F1	activates	R-2764	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05643	ITGB7	up-regulates	POU3F1	represses	R-1666	25	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05685	FAT2	down-regulates	POU4F1	activates	R-2764	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05808	SYNE2	down-regulates	POU4F1	activates	R-2764	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05811	SYNE2	up-regulates	POU3F1	represses	R-1666	25	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-06164	MDGA2	down-regulates	POU4F1	activates	R-2764	11	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-06387	FAT3	down-regulates	MAFK	represses	R-3329	6	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-06577	RLTPR	down-regulates	SATB1	activates	R-1693	24	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-06713	ATRX	up-regulates	SATB1	activates	R-1693	24	15	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-06826	ATRX	up-regulates	POU4F1	activates	R-2764	11	11	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-08043	ABCC4	down-regulates	HLX	represses	R-3585	10	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-09153	RANBP6	down-regulates	MAFK	represses	R-3329	6	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-09420	ZIC4	down-regulates	POU4F1	activates	R-2764	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-10357	FGG	down-regulates	FOXC2	represses	R-2644	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-10456	MYOM2	up-regulates	MAFK	represses	R-3329	6	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-10459	MYOM2	down-regulates	POU4F1	activates	R-2764	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-10619	ITIH5L	down-regulates	ALX4	represses	R-2909	20	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-11081	SNX9	up-regulates	FOXD3	represses	R-577	25	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-11088	SNX9	down-regulates	POU4F1	activates	R-2764	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-13055	AKD1	down-regulates	FOXC2	represses	R-2644	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-13795	ADAMTS8	down-regulates	HLX	represses	R-3585	10	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-14723	BCOR	down-regulates	HLX	represses	R-3585	10	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-14728	BCOR	down-regulates	FOXC2	represses	R-2644	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-14780	ZNF681	down-regulates	FOXC2	represses	R-2644	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-16090	NFIX	down-regulates	FOXC2	represses	R-2644	11	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-16941	TIE1	down-regulates	BARX2	represses	R-1752	7	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-17241	MAP3K7	down-regulates	BARX2	represses	R-1752	7	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-17375	TBC1D8	down-regulates	ALX4	represses	R-2909	20	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-17387	TBC1D8	down-regulates	HLX	represses	R-3585	10	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-17728	PCDHB13	up-regulates	HLX	represses	R-3585	10	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-17754	PCDHB13	up-regulates	FOXC2	represses	R-2644	11	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-18291	MEGF8	down-regulates	POU4F1	activates	R-2764	11	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-18530	OR5D16	up-regulates	SATB1	activates	R-1693	24	7	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-19227	NF1	down-regulates	SATB1	activates	R-1693	24	9	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-19284	NF1	down-regulates	POU4F1	activates	R-2764	11	7	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-19383	NF1	up-regulates	HLX	represses	R-3585	10	10	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20218	GPR15	up-regulates	HLX	represses	R-3585	10	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20541	ADCY1	down-regulates	SATB1	activates	R-1693	24	8	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20575	ADCY1	down-regulates	POU4F1	activates	R-2764	11	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-20628	ABCD2	down-regulates	SATB1	activates	R-1693	24	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-21996	ITGB4	down-regulates	POU4F1	activates	R-2764	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22195	PODXL	down-regulates	MAFK	represses	R-3329	6	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22314	IDH1	down-regulates	MAFK	represses	R-3329	6	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22322	IDH1	up-regulates	SATB1	activates	R-1693	24	18	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-22470	IDH1	up-regulates	POU4F1	activates	R-2764	11	11	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-23054	AOX1	down-regulates	FOXC2	represses	R-2644	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-23610	TP53	up-regulates	SATB1	activates	R-1693	24	17	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-23741	TP53	up-regulates	POU4F1	activates	R-2764	11	10	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24207	OR4K5	down-regulates	FOXC2	represses	R-2644	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24682	UGT2A3	down-regulates	FOXC2	represses	R-2644	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24754	ADCY9	down-regulates	POU4F1	activates	R-2764	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-25810	CD163	up-regulates	SATB1	activates	R-1693	24	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-27757	CSMD3	down-regulates	SATB1	activates	R-1693	24	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-28056	CELSR3	up-regulates	SATB1	activates	R-1693	24	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-28068	CELSR3	up-regulates	POU4F1	activates	R-2764	11	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-28440	MYO9B	down-regulates	FOXC2	represses	R-2644	11	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-29162	AQP10	up-regulates	SATB1	activates	R-1693	24	7	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-29526	TM7SF4	down-regulates	POU4F1	activates	R-2764	11	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-30213	TEP1	down-regulates	FOXD3	represses	R-577	25	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-31205	RAG1	down-regulates	FOXD3	represses	R-577	25	1	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)

Program

Pr-61

Program Pr-61

Genes (44)

Regulons (28)

Regulons in program Pr-61

Genes in program Pr-61

Causal Mechanistic Flows with Program Pr-61

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