Program

Program Pr-177

Genes (19)

TNPO1, ANGPT2, VEGFA, IGFBP5, PALLD, ADM, SLC16A1, 9-Sep, CRY1, SAMD4A, MSN, ABCA1, POU3F2, CEBPD, TNC, TGFB1I1, KBTBD2, MID1, INHBB

Regulons (7)

R-670, R-892, R-1185, R-1285, R-2002, R-3106, R-3602

Regulons in program Pr-177

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-670	2.52192	8	17
R-892	3.05518	11	2
R-1185	3.01964	6	15
R-1285	2.82773	13	3
R-2002	2.77865	11	23
R-3106	2.72728	13	7
R-3602	3.56909	5	17

Genes in program Pr-177

EnsEMBL Id	Entrez Id	Preferred
ENSG00000083312	3842	TNPO1
ENSG00000091879	285	ANGPT2
ENSG00000112715	7422	VEGFA
ENSG00000115461	3488	IGFBP5
ENSG00000129116	23022	PALLD
ENSG00000148926	133	ADM
ENSG00000281917	6566	SLC16A1
ENSG00000282302	10801	9-Sep
ENSG00000008405	1407	CRY1
ENSG00000020577	23034	SAMD4A
ENSG00000147065	4478	MSN
ENSG00000165029	19	ABCA1
ENSG00000184486	5454	POU3F2
ENSG00000221869	1052	CEBPD
ENSG00000041982	3371	TNC
ENSG00000140682	7041	TGFB1I1
ENSG00000170852	25948	KBTBD2
ENSG00000101871	4281	MID1
ENSG00000163083	3625	INHBB

Causal Mechanistic Flows with Program Pr-177

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-00696	HMCN1	up-regulates	LTF	activates	R-3602	2	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-00975	TPTE	down-regulates	LHX3	represses	R-2002	24	9	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-01182	SKAP2	down-regulates	LHX3	represses	R-2002	24	4	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-01474	MTOR	down-regulates	LHX3	represses	R-2002	24	8	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-01523	CACNA1B	down-regulates	NKX2-8	represses	R-670	12	2	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-04756	ADAMTS20	down-regulates	LHX3	represses	R-2002	24	4	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-04783	ADAMTS20	down-regulates	PAX2	represses	R-1185	4	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-04890	ABCC5	down-regulates	PAX6	activates	R-1285	16	5	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-06001	C4orf35	up-regulates	LTF	activates	R-3602	2	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-07063	ATRX	down-regulates	LTF	activates	R-3602	2	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-07187	ATRX	up-regulates	FOXO4	represses	R-3106	17	12	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-07415	THOC2	down-regulates	LHX3	represses	R-2002	24	8	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-07467	LRRIQ1	down-regulates	NKX2-8	represses	R-670	12	1	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-07500	MAG	down-regulates	PAX2	represses	R-1185	4	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-07552	AHNAK2	down-regulates	NKX2-8	represses	R-670	12	1	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-07740	OR10G8	down-regulates	PAX2	represses	R-1185	4	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-08728	FBLN2	down-regulates	NKX2-8	represses	R-670	12	3	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-08865	FNDC1	down-regulates	NKX2-8	represses	R-670	12	1	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-08965	ARHGAP32	up-regulates	FOXO4	represses	R-3106	17	2	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-09376	CUL1	down-regulates	LHX3	represses	R-2002	24	2	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-10101	TACR3	down-regulates	PAX2	represses	R-1185	4	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-11165	ODF4	down-regulates	PAX2	represses	R-1185	4	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-11240	OR5W2	down-regulates	NKX2-8	represses	R-670	12	5	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-11374	LRRC50	down-regulates	PAX2	represses	R-1185	4	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-11587	FNDC3B	down-regulates	LHX3	represses	R-2002	24	1	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-11598	DBR1	down-regulates	NKX2-8	represses	R-670	12	1	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-11874	PALM2-AKAP2	down-regulates	LHX3	represses	R-2002	24	5	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-13447	FMN1	down-regulates	RREB1	represses	R-892	15	5	Drugs (18) Regulator Drugs (0) Regulon Drugs (18) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-13587	FMN1	up-regulates	LTF	activates	R-3602	2	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-13971	REM1	up-regulates	LTF	activates	R-3602	2	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-14142	CD1D	down-regulates	LHX3	represses	R-2002	24	2	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-14201	ZNF516	down-regulates	LHX3	represses	R-2002	24	4	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-14519	GPR112	down-regulates	NKX2-8	represses	R-670	12	3	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-14887	SDHAP3	down-regulates	NKX2-8	represses	R-670	12	4	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-15592	DCHS2	down-regulates	NKX2-8	represses	R-670	12	3	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-15656	DCHS2	down-regulates	LHX3	represses	R-2002	24	5	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-15689	DCHS2	down-regulates	PAX2	represses	R-1185	4	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-17348	CDKL5	down-regulates	LTF	activates	R-3602	2	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-17414	LGALS8	down-regulates	NKX2-8	represses	R-670	12	1	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-17831	CSF2RB	down-regulates	LHX3	represses	R-2002	24	1	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-18095	DLGAP2	up-regulates	LTF	activates	R-3602	2	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-18470	LAMA1	down-regulates	LHX3	represses	R-2002	24	8	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-18499	LAMA1	down-regulates	PAX2	represses	R-1185	4	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-20668	CYP4B1	down-regulates	LHX3	represses	R-2002	24	2	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-20747	ALPK1	down-regulates	FOXO4	represses	R-3106	17	3	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-21077	KRTAP4-7	up-regulates	LTF	activates	R-3602	2	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-21951	FAT1	down-regulates	LHX3	represses	R-2002	24	4	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-22569	IDH1	up-regulates	LHX3	represses	R-2002	24	21	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-22823	IDH1	down-regulates	LTF	activates	R-3602	2	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-23009	IDH1	up-regulates	FOXO4	represses	R-3106	17	14	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-23342	CCDC132	up-regulates	LTF	activates	R-3602	2	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-23552	TP53	up-regulates	NKX2-8	represses	R-670	12	6	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-23981	TP53	down-regulates	LTF	activates	R-3602	2	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-24123	TP53	up-regulates	FOXO4	represses	R-3106	17	9	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-24231	LRRC7	up-regulates	LTF	activates	R-3602	2	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-24766	CHAT	up-regulates	LTF	activates	R-3602	2	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-24794	HIST1H2BE	down-regulates	LHX3	represses	R-2002	24	6	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-24913	NLRP1	up-regulates	PAX6	activates	R-1285	16	3	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-24956	NLRP1	down-regulates	RREB1	represses	R-892	15	1	Drugs (18) Regulator Drugs (0) Regulon Drugs (18) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-24958	NLRP1	down-regulates	LHX3	represses	R-2002	24	3	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-24991	NLRP1	down-regulates	PAX2	represses	R-1185	4	3	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-25141	FLT3	down-regulates	LHX3	represses	R-2002	24	4	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-25679	SRGAP1	down-regulates	PAX2	represses	R-1185	4	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-26496	EGFR	up-regulates	LTF	activates	R-3602	2	2	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-26679	FBN2	down-regulates	NKX2-8	represses	R-670	12	2	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-27227	HTR3A	down-regulates	FOXO4	represses	R-3106	17	1	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-27255	PDYN	up-regulates	LTF	activates	R-3602	2	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-27488	KRTAP20-2	down-regulates	NKX2-8	represses	R-670	12	2	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-28234	REPIN1	up-regulates	LTF	activates	R-3602	2	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-28259	ZIC1	down-regulates	LHX3	represses	R-2002	24	4	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-28936	NPHS1	down-regulates	NKX2-8	represses	R-670	12	2	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-28947	NPHS1	down-regulates	LHX3	represses	R-2002	24	3	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-29093	TUBB4Q	down-regulates	LHX3	represses	R-2002	24	1	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-29326	C12orf51	down-regulates	PAX2	represses	R-1185	4	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-29337	C12orf51	down-regulates	FOXO4	represses	R-3106	17	3	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-29354	RPL13AP6	down-regulates	PAX2	represses	R-1185	4	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-29809	SLC5A7	down-regulates	PAX2	represses	R-1185	4	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-30027	FAM126B	down-regulates	NKX2-8	represses	R-670	12	2	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-30034	FAM126B	up-regulates	PAX6	activates	R-1285	16	4	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-30165	NLRP7	down-regulates	PAX2	represses	R-1185	4	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-30310	MSR1	up-regulates	LTF	activates	R-3602	2	1	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) ENIBARCIMAB
CMF-30863	ARMC4	down-regulates	NKX2-8	represses	R-670	12	1	Drugs (17) Regulator Drugs (0) Regulon Drugs (17) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-30871	ARMC4	down-regulates	LHX3	represses	R-2002	24	2	Drugs (19) Regulator Drugs (0) Regulon Drugs (19) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-35348	ATRX	up-regulates	hsa-mir-140	represses	R-3106	3	3	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-35350	ATRX	up-regulates	hsa-mir-140	represses	R-1285	3	3	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-39999	GPR15	down-regulates	hsa-mir-140	represses	R-3106	3	1	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-40670	IDH1	up-regulates	hsa-mir-140	represses	R-3106	3	3	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB
CMF-40672	IDH1	up-regulates	hsa-mir-140	represses	R-1285	3	3	Drugs (20) Regulator Drugs (0) Regulon Drugs (20) BEVACIZUMAB, CONBERCEPT, AMG-780, MEDI-3617, PEGAPTANIB SODIUM, ENIBARCIMAB, F16SIP 131I, TREBANANIB, PEGAPTANIB OCTASODIUM, MUPARFOSTAT, F16IL2, VANUCIZUMAB, PROBUCOL, RANIBIZUMAB, FARICIMAB, CVX-060, ABICIPAR PEGOL, NESVACUMAB, AFLIBERCEPT, BROLUCIZUMAB

Pr-177

Program Pr-177

Genes (19)

Regulons (7)

Regulons in program Pr-177

Genes in program Pr-177

Causal Mechanistic Flows with Program Pr-177

Regulator Drugs (0)

Regulon Drugs (1)

Regulator Drugs (0)

Regulon Drugs (19)

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Regulon Drugs (19)

Regulator Drugs (0)

Regulon Drugs (19)

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Regulon Drugs (17)

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Regulon Drugs (19)

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Regulon Drugs (1)

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Regulon Drugs (20)

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Regulon Drugs (1)

Regulator Drugs (0)

Regulon Drugs (20)

Regulator Drugs (0)

Regulon Drugs (19)

Regulator Drugs (0)

Regulon Drugs (17)

Regulator Drugs (0)

Regulon Drugs (1)

Regulator Drugs (0)

Regulon Drugs (17)

Regulator Drugs (0)

Regulon Drugs (1)

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Regulon Drugs (17)

Regulator Drugs (0)

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Regulon Drugs (20)

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Regulon Drugs (19)

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Regulon Drugs (1)

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Regulon Drugs (17)

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Regulon Drugs (19)

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Regulon Drugs (19)

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Regulon Drugs (18)

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Regulon Drugs (19)

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Regulon Drugs (17)

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Regulon Drugs (19)