Program – gbmMINER Portal

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Program – gbmMINER Portal

Program

Program Pr-175

Genes (40)

BAD, CD81, SORBS3, SIRT3, B3GAT3, IRF2, GPR137, C11orf68, GRINA, THAP7, TFE3, CRAT, FAM134A, CTBP1, MAPK7, HGS, RPS6KA4, PLEKHB1, DNM2, CSK, GLTP, RXRG, ALPL, PACS2, PYGB, ST3GAL5, NMT1, PMVK, VPS11, BRD9, ST8SIA5, TFR2, FOXK2, PCYOX1L, CHMP7, MRM1, PPP1R3C, RAD23A, MOCS3, FAM134C

Regulons (7)

R-302, R-489, R-827, R-1247, R-2131, R-2736, R-3418

Regulons in program Pr-175

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-302	2.00311	10	9
R-489	0.54155	6	3
R-827	0.981864	8	1
R-1247	0.404619	5	13
R-2131	2.01869	7	6
R-2736	-0.660265	5	7
R-3418	-0.462777	6	5

Genes in program Pr-175

EnsEMBL Id	Entrez Id	Preferred
ENSG00000002330	572	BAD
ENSG00000110651	975	CD81
ENSG00000120896	10174	SORBS3
ENSG00000142082	23410	SIRT3
ENSG00000149541	26229	B3GAT3
ENSG00000168310	3660	IRF2
ENSG00000173264	56834	GPR137
ENSG00000175573	83638	C11orf68
ENSG00000178719	2907	GRINA
ENSG00000184436	80764	THAP7
ENSG00000068323	7030	TFE3
ENSG00000095321	1384	CRAT
ENSG00000144567	79137	FAM134A
ENSG00000159692	1487	CTBP1
ENSG00000166484	5598	MAPK7
ENSG00000185359	9146	HGS
ENSG00000162302	8986	RPS6KA4
ENSG00000021300	58473	PLEKHB1
ENSG00000079805	1785	DNM2
ENSG00000103653	1445	CSK
ENSG00000139433	51228	GLTP
ENSG00000143171	6258	RXRG
ENSG00000162551	249	ALPL
ENSG00000179364	23241	PACS2
ENSG00000100994	5834	PYGB
ENSG00000115525	8869	ST3GAL5
ENSG00000136448	4836	NMT1
ENSG00000163344	10654	PMVK
ENSG00000280616	55823	VPS11
ENSG00000028310	65980	BRD9
ENSG00000101638	29906	ST8SIA5
ENSG00000106327	7036	TFR2
ENSG00000141568	3607	FOXK2
ENSG00000145882	78991	PCYOX1L
ENSG00000147457	91782	CHMP7
ENSG00000278619	79922	MRM1
ENSG00000119938	5507	PPP1R3C
ENSG00000179262	5886	RAD23A
ENSG00000124217	27304	MOCS3
ENSG00000141699	162427	FAM134C

Causal Mechanistic Flows with Program Pr-175

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-03687	DSP	up-regulates	NFKB1	activates	R-302	25	13	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-05851	LGI2	up-regulates	NFKB1	activates	R-302	25	3	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-11298	RPTN	up-regulates	NFKB1	activates	R-302	25	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-14369	ST18	down-regulates	NFKB1	activates	R-302	25	2	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-24440	SEMA3C	down-regulates	NFKB1	activates	R-302	25	6	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-30041	FAM126B	up-regulates	NFKB1	activates	R-302	25	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-31631	PDGFR_BETA_SIGNALING_PATHWAY	up-regulates	NFKB1	activates	R-302	25	5	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)
CMF-32482	CXCR4_MEDIATED_SIGNALING_EVENTS	up-regulates	NFKB1	activates	R-302	25	4	Drugs (0) Regulator Drugs (0) Regulon Drugs (0)

CMFlow summary not available

Enrichment summary not available