Pr-133
Genes (135)
IL7, HTATIP2, ITGA4, DOK1, MBD4, PTPN7, CRTAP, MYD88, COQ2, CD47, HERPUD1, ATG7, MICB, VNN1, SLC31A1, TMSB10, CASP8, SLC25A24, TCIRG1, TGFBI, FKBP11, IL15RA, ITGB1, CAST, CASP7, ANXA2, SFT2D2, NTAN1, CD46, CD164, LUM, IQGAP1, RBMS1, ANXA4, IFNGR2, HEXB, OBFC1, CLEC2B, KYNU, ARPC2, RAB27A, ADPGK, HFE, MAT2B, STK3, PPIC, MFN1, PAWR, XBP1, PLEK2, ASB9, PERP, RAB38, RHOD, FOLR1, PRKAA1, CEPT1, TANK, SLFN12, S100A14, CD2AP, SNAI1, FKBP10, PRKCDBP, TEAD4, LY6E, SNX16, CTBS, SLC19A2, CLIC2, GK, CHUK, MGST2, TRIM38, PPARG, P2RX4, POLD4, PRR13, HEXA, TMEM38B, ASIP, GNPDA1, LRRC42, ZNF706, SLC39A1, HIST1H2BC, HIST2H2BE, HIST1H2AG, HIST1H2AL, HIST1H2BF, HIST1H2AM, AFP, SHBG, MTTP, ACAA2, BTC, TXNRD1, TRADD, BACE2, TSPAN4, TXNDC5, LLGL2, TUBD1, C17orf75, ATF1, NMI, SIRT5, GABPA, USP25, ZMYM6, MYCBP, RLN2, PEX13, CRLF3, TNFSF4, ZFAND1, SDHD, CD59, FAH, PFN1, CALU, GLB1, IL10RB, SRPX2, IL13RA1, ST6GAL1, APBB1IP, PIK3CG, TGFBR1, B3GNT2, PELO, AVEN, DES, MSC, SLC35C1Regulons (47)
R-145, R-364, R-384, R-398, R-657, R-680, R-691, R-1076, R-1081, R-1086, R-1154, R-1337, R-1352, R-1384, R-1585, R-1628, R-1690, R-1695, R-1806, R-1989, R-2015, R-2162, R-2174, R-2188, R-2286, R-2439, R-2450, R-2481, R-2494, R-2714, R-2721, R-2744, R-2778, R-2859, R-2912, R-2926, R-3018, R-3096, R-3132, R-3173, R-3336, R-3383, R-3557, R-3568, R-3598, R-3687, R-3692Regulons in program Pr-133
| Regulon | Cox Hazard Ratio | # genes | # causal flows |
|---|---|---|---|
| R-145 | 2.57178 | 10 | 10 |
| R-364 | 1.0623 | 7 | 5 |
| R-384 | 1.91464 | 14 | 20 |
| R-398 | 2.68655 | 13 | 4 |
| R-657 | 1.83876 | 14 | 3 |
| R-680 | 2.56643 | 16 | 12 |
| R-691 | 1.89415 | 5 | 6 |
| R-1076 | 1.66916 | 10 | 1 |
| R-1081 | 2.22713 | 6 | 6 |
| R-1086 | 1.51242 | 7 | 7 |
| R-1154 | 0.683997 | 6 | 16 |
| R-1337 | 1.05086 | 9 | 9 |
| R-1352 | 1.47282 | 5 | 17 |
| R-1384 | -0.158359 | 6 | 12 |
| R-1585 | 1.9342 | 7 | 5 |
| R-1628 | 0.302857 | 25 | 6 |
| R-1690 | 1.81448 | 6 | 8 |
| R-1695 | 1.89415 | 5 | 8 |
| R-1806 | 2.64858 | 7 | 21 |
| R-1989 | 0.675816 | 5 | 10 |
| R-2015 | 1.9661 | 5 | 5 |
| R-2162 | 0.831177 | 22 | 2 |
| R-2174 | 1.90867 | 7 | 4 |
| R-2188 | 1.66921 | 6 | 6 |
| R-2286 | 0.163124 | 5 | 15 |
| R-2439 | 1.91375 | 11 | 5 |
| R-2450 | 1.81814 | 6 | 8 |
| R-2481 | 2.24622 | 10 | 6 |
| R-2494 | 1.78624 | 5 | 5 |
| R-2714 | 1.83602 | 5 | 8 |
| R-2721 | 0.377846 | 10 | 3 |
| R-2744 | 1.09398 | 5 | 11 |
| R-2778 | 2.03902 | 6 | 6 |
| R-2859 | 1.50061 | 5 | 6 |
| R-2912 | 1.02102 | 11 | 9 |
| R-2926 | 2.42938 | 5 | 7 |
| R-3018 | 1.72473 | 13 | 13 |
| R-3096 | 2.42612 | 20 | 9 |
| R-3132 | 1.81814 | 6 | 8 |
| R-3173 | 2.14502 | 9 | 18 |
| R-3336 | -0.0629838 | 7 | 11 |
| R-3383 | 2.0216 | 5 | 6 |
| R-3557 | 1.81814 | 6 | 5 |
| R-3568 | 1.98331 | 6 | 3 |
| R-3598 | 1.36545 | 5 | 4 |
| R-3687 | 1.83876 | 14 | 9 |
| R-3692 | 2.0869 | 10 | 10 |
Genes in program Pr-133
Causal Mechanistic Flows with Program Pr-133
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00253 | CDC27 | down-regulates | IRF8 | activates | R-398 | 18 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, ABITUZUMAB |
| CMF-00318 | COL6A3 | up-regulates | ARID3A | activates | R-680 | 19 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-00557 | HMCN1 | up-regulates | ARID3A | activates | R-680 | 19 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-00691 | HMCN1 | up-regulates | PRDM1 | activates | R-145 | 21 | 16 | Drugs (5) |
| CMF-00772 | TPTE2 | up-regulates | MYCN | represses | R-1806 | 5 | 1 | Drugs (2) |
| CMF-01072 | ZNF292 | down-regulates | HMGA1 | activates | R-1081 | 16 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01081 | ZNF292 | up-regulates | ALX4 | represses | R-2926 | 20 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01108 | ZNF292 | down-regulates | ARID3A | activates | R-680 | 19 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-01381 | CNTN5 | up-regulates | NR2F1 | represses | R-2778 | 15 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01382 | CNTN5 | down-regulates | ARID3A | activates | R-680 | 19 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-01607 | MCM6 | down-regulates | ALX4 | represses | R-2926 | 20 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01614 | MCM6 | down-regulates | SIX6 | represses | R-3173 | 4 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-02303 | ERG | down-regulates | SIX6 | represses | R-3173 | 4 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-03099 | LAMA3 | down-regulates | PRDM1 | activates | R-145 | 21 | 4 | Drugs (5) |
| CMF-04236 | RBPJL | down-regulates | LHX3 | represses | R-2015 | 24 | 11 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04306 | RBPJL | up-regulates | IRF8 | activates | R-398 | 18 | 6 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, ABITUZUMAB |
| CMF-04315 | RBPJL | down-regulates | MYCN | represses | R-1806 | 5 | 2 | Drugs (2) |
| CMF-04476 | MYH8 | up-regulates | GATA3 | activates | R-3096 | 7 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-04578 | LAMC3 | down-regulates | PRDM1 | activates | R-145 | 21 | 7 | Drugs (5) |
| CMF-04589 | LAMC3 | up-regulates | MYCN | represses | R-1806 | 5 | 2 | Drugs (2) |
| CMF-04644 | CYP4F12 | up-regulates | MYCN | represses | R-1806 | 5 | 2 | Drugs (2) |
| CMF-04805 | SLC6A3 | up-regulates | SOX21 | represses | R-3568 | 9 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04918 | ABCC5 | down-regulates | IRF7 | activates | R-2481 | 21 | 9 | Drugs (1) |
| CMF-05179 | XIRP2 | down-regulates | PRDM1 | activates | R-145 | 21 | 3 | Drugs (5) |
| CMF-05639 | ITGB7 | down-regulates | SIX6 | represses | R-3173 | 4 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-06556 | STAG2 | down-regulates | ALX4 | represses | R-2926 | 20 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06801 | ATRX | down-regulates | IRF7 | activates | R-2481 | 21 | 19 | Drugs (1) |
| CMF-07093 | ATRX | up-regulates | MYCN | represses | R-1806 | 5 | 4 | Drugs (2) |
| CMF-07123 | ATRX | down-regulates | ELF3 | activates | R-3692 | 14 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07140 | ATRX | down-regulates | GATA3 | activates | R-3096 | 7 | 5 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-07410 | THOC2 | down-regulates | SIX6 | represses | R-3173 | 4 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-07988 | OR5D13 | down-regulates | SIX6 | represses | R-3173 | 4 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-08272 | KIF4A | down-regulates | ARID3A | activates | R-680 | 19 | 6 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-08297 | KIF4A | up-regulates | MYCN | represses | R-1806 | 5 | 2 | Drugs (2) |
| CMF-08624 | LOC401010 | down-regulates | GATA3 | activates | R-3096 | 7 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-08912 | ZNF618 | down-regulates | NR2F1 | represses | R-2778 | 15 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09036 | NALCN | up-regulates | MYCN | represses | R-1806 | 5 | 1 | Drugs (2) |
| CMF-09071 | FLT1 | down-regulates | IRF7 | activates | R-2481 | 21 | 3 | Drugs (1) |
| CMF-09200 | TANC2 | down-regulates | SIX6 | represses | R-3173 | 4 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-09221 | TANC2 | up-regulates | PRDM1 | activates | R-145 | 21 | 8 | Drugs (5) |
| CMF-09231 | TANC2 | down-regulates | MYCN | represses | R-1806 | 5 | 1 | Drugs (2) |
| CMF-09265 | RP1 | down-regulates | HMGA1 | activates | R-1081 | 16 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-10222 | SEMG1 | down-regulates | ARID3A | activates | R-680 | 19 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-10920 | BMP5 | up-regulates | NR2F1 | represses | R-2778 | 15 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11305 | RPTN | down-regulates | SIX6 | represses | R-3173 | 4 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-11621 | CHSY3 | down-regulates | HMGA1 | activates | R-1081 | 16 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12567 | ADAMTS16 | down-regulates | ELF3 | activates | R-3692 | 14 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12670 | WDFY3 | down-regulates | SIX6 | represses | R-3173 | 4 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-12672 | WDFY3 | down-regulates | LHX3 | represses | R-2015 | 24 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13741 | TUBA3C | down-regulates | MYCN | represses | R-1806 | 5 | 2 | Drugs (2) |
| CMF-13888 | HRH2 | down-regulates | NR2F1 | represses | R-2778 | 15 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-14198 | ZNF516 | down-regulates | SIX6 | represses | R-3173 | 4 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-14505 | PRKCD | down-regulates | GATA3 | activates | R-3096 | 7 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-14764 | SLC5A12 | up-regulates | IRF8 | activates | R-398 | 18 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, ABITUZUMAB |
| CMF-14983 | XK | up-regulates | SOX21 | represses | R-3568 | 9 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-15540 | TAS2R41 | down-regulates | SIX6 | represses | R-3173 | 4 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-15726 | FN1 | down-regulates | SIX6 | represses | R-3173 | 4 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-16664 | DNAJC11 | down-regulates | SIX6 | represses | R-3173 | 4 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-17262 | MAP3K7 | down-regulates | ELF3 | activates | R-3692 | 14 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17351 | CDKL5 | up-regulates | MYCN | represses | R-1806 | 5 | 1 | Drugs (2) |
| CMF-17524 | CNTNAP3 | up-regulates | IRF7 | activates | R-2481 | 21 | 5 | Drugs (1) |
| CMF-17678 | DCAF8L2 | down-regulates | ELF3 | activates | R-3692 | 14 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17871 | SYT16 | up-regulates | MYCN | represses | R-1806 | 5 | 1 | Drugs (2) |
| CMF-17948 | PRPF40B | down-regulates | HMGA1 | activates | R-1081 | 16 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18027 | PRPF40B | down-regulates | PRDM1 | activates | R-145 | 21 | 12 | Drugs (5) |
| CMF-18139 | SGIP1 | down-regulates | LHX3 | represses | R-2015 | 24 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18667 | CHRND | down-regulates | ELF3 | activates | R-3692 | 14 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18696 | MPP7 | down-regulates | ARID3A | activates | R-680 | 19 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-19274 | NF1 | up-regulates | ARID3A | activates | R-680 | 19 | 9 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-19324 | NF1 | down-regulates | SIX6 | represses | R-3173 | 4 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-19502 | NF1 | up-regulates | PRDM1 | activates | R-145 | 21 | 16 | Drugs (5) |
| CMF-19537 | NF1 | down-regulates | MYCN | represses | R-1806 | 5 | 3 | Drugs (2) |
| CMF-19557 | NF1 | up-regulates | GATA3 | activates | R-3096 | 7 | 6 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-19802 | CDH9 | down-regulates | PRDM1 | activates | R-145 | 21 | 3 | Drugs (5) |
| CMF-20127 | TDRD9 | down-regulates | SIX6 | represses | R-3173 | 4 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-20343 | FTMT | down-regulates | ARID3A | activates | R-680 | 19 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-20408 | CUX2 | up-regulates | ARID3A | activates | R-680 | 19 | 8 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-20417 | CUX2 | down-regulates | SIX6 | represses | R-3173 | 4 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-20535 | ADCY1 | down-regulates | NR2F1 | represses | R-2778 | 15 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20571 | ADCY1 | down-regulates | ALX4 | represses | R-2926 | 20 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20582 | ADCY1 | down-regulates | LHX3 | represses | R-2015 | 24 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20661 | CYP4B1 | down-regulates | ALX4 | represses | R-2926 | 20 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20667 | CYP4B1 | down-regulates | SIX6 | represses | R-3173 | 4 | 1 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-21031 | KRTAP4-7 | up-regulates | ARID3A | activates | R-680 | 19 | 6 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-21079 | KRTAP4-7 | down-regulates | MYCN | represses | R-1806 | 5 | 3 | Drugs (2) |
| CMF-21170 | ADAM30 | down-regulates | MYCN | represses | R-1806 | 5 | 2 | Drugs (2) |
| CMF-21537 | KLHL34 | up-regulates | MYCN | represses | R-1806 | 5 | 1 | Drugs (2) |
| CMF-21598 | MUC17 | down-regulates | ALX4 | represses | R-2926 | 20 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21630 | MUC17 | up-regulates | IRF7 | activates | R-2481 | 21 | 12 | Drugs (1) |
| CMF-21897 | PRAME | down-regulates | SIX6 | represses | R-3173 | 4 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-22177 | PDGFRA | down-regulates | ELF3 | activates | R-3692 | 14 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22441 | IDH1 | down-regulates | IRF7 | activates | R-2481 | 21 | 20 | Drugs (1) |
| CMF-22575 | IDH1 | up-regulates | LHX3 | represses | R-2015 | 24 | 21 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22774 | IDH1 | down-regulates | PRDM1 | activates | R-145 | 21 | 18 | Drugs (5) |
| CMF-22866 | IDH1 | up-regulates | MYCN | represses | R-1806 | 5 | 4 | Drugs (2) |
| CMF-22914 | IDH1 | down-regulates | ELF3 | activates | R-3692 | 14 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22931 | IDH1 | down-regulates | GATA3 | activates | R-3096 | 7 | 5 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-23056 | AOX1 | down-regulates | ELF3 | activates | R-3692 | 14 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24014 | TP53 | up-regulates | MYCN | represses | R-1806 | 5 | 3 | Drugs (2) |
| CMF-24192 | OR4K5 | down-regulates | HMGA1 | activates | R-1081 | 16 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25833 | CD163 | up-regulates | MYCN | represses | R-1806 | 5 | 3 | Drugs (2) |
| CMF-25862 | PIK3CA | up-regulates | HMGA1 | activates | R-1081 | 16 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26270 | CEP250 | up-regulates | SOX21 | represses | R-3568 | 9 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-26276 | CEP250 | down-regulates | PRDM1 | activates | R-145 | 21 | 7 | Drugs (5) |
| CMF-26651 | C5AR1 | down-regulates | MYCN | represses | R-1806 | 5 | 1 | Drugs (2) |
| CMF-27446 | SDK1 | down-regulates | ALX4 | represses | R-2926 | 20 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27610 | ANKRD36 | down-regulates | SIX6 | represses | R-3173 | 4 | 2 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-27710 | FAM83H | up-regulates | MYCN | represses | R-1806 | 5 | 2 | Drugs (2) |
| CMF-27719 | FAM83H | down-regulates | GATA3 | activates | R-3096 | 7 | 5 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-28118 | CELSR3 | down-regulates | GATA3 | activates | R-3096 | 7 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-28401 | MYO9B | down-regulates | ARID3A | activates | R-680 | 19 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, ABITUZUMAB |
| CMF-28742 | SYN3 | down-regulates | IRF8 | activates | R-398 | 18 | 4 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, RECOMBINANT HUMAN INTERLEUKIN-15, ABITUZUMAB |
| CMF-29245 | AQP10 | down-regulates | GATA3 | activates | R-3096 | 7 | 3 | Drugs (8) Regulator Drugs (0)Regulon Drugs (8)ATN-161, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-29269 | ITGAM | up-regulates | MYCN | represses | R-1806 | 5 | 1 | Drugs (2) |
| CMF-29378 | UHRF1BP1L | down-regulates | ELF3 | activates | R-3692 | 14 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30778 | ZDBF2 | down-regulates | ELF3 | activates | R-3692 | 14 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-31074 | LRFN2 | up-regulates | NR2F1 | represses | R-2778 | 15 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-33925 | MYO7B | down-regulates | hsa-mir-301 | represses | R-2481 | 37 | 3 | Drugs (1) |
| CMF-34069 | ZNF814 | up-regulates | hsa-mir-129 | represses | R-2481 | 155 | 8 | Drugs (1) |
| CMF-34074 | ZNF814 | up-regulates | hsa-mir-331 | represses | R-2481 | 7 | 1 | Drugs (1) |
| CMF-34365 | OR5D14 | down-regulates | hsa-mir-346 | represses | R-2481 | 20 | 2 | Drugs (1) |
| CMF-34372 | OR5D14 | down-regulates | hsa-mir-328 | represses | R-2481 | 27 | 13 | Drugs (1) |
| CMF-34415 | GCC2 | up-regulates | hsa-mir-153 | represses | R-2481 | 62 | 3 | Drugs (1) |
| CMF-34831 | ITPR3 | down-regulates | hsa-mir-346 | represses | R-2481 | 20 | 1 | Drugs (1) |
| CMF-34832 | ITPR3 | down-regulates | hsa-mir-328 | represses | R-2481 | 27 | 1 | Drugs (1) |
| CMF-34951 | DLC1 | up-regulates | hsa-mir-331 | represses | R-2481 | 7 | 1 | Drugs (1) |
| CMF-34982 | SIRPG | down-regulates | hsa-mir-346 | represses | R-2481 | 20 | 18 | Drugs (1) |
| CMF-35032 | FGFR3 | down-regulates | hsa-mir-346 | represses | R-2481 | 20 | 16 | Drugs (1) |
| CMF-35104 | SBF1 | down-regulates | hsa-mir-346 | represses | R-2481 | 20 | 1 | Drugs (1) |
| CMF-35373 | ATRX | up-regulates | hsa-mir-301 | represses | R-2481 | 37 | 32 | Drugs (1) |
| CMF-36012 | AHNAK2 | up-regulates | hsa-mir-331 | represses | R-2481 | 7 | 1 | Drugs (1) |
| CMF-36309 | FOXR2 | up-regulates | hsa-mir-301 | represses | R-2481 | 37 | 12 | Drugs (1) |
| CMF-37234 | DNAH7 | up-regulates | hsa-mir-129 | represses | R-2481 | 155 | 1 | Drugs (1) |
| CMF-38228 | NCAPG | down-regulates | hsa-mir-346 | represses | R-2481 | 20 | 1 | Drugs (1) |
| CMF-38547 | TBX5 | down-regulates | hsa-mir-346 | represses | R-2481 | 20 | 1 | Drugs (1) |
| CMF-38552 | TBX5 | down-regulates | hsa-mir-301 | represses | R-2481 | 37 | 4 | Drugs (1) |
| CMF-38888 | CNTNAP3 | down-regulates | hsa-mir-346 | represses | R-2481 | 20 | 2 | Drugs (1) |
| CMF-40049 | CUX2 | down-regulates | hsa-mir-153 | represses | R-2481 | 62 | 10 | Drugs (1) |
| CMF-40262 | SH3TC2 | down-regulates | hsa-mir-328 | represses | R-2481 | 27 | 1 | Drugs (1) |
| CMF-40431 | IDH1 | up-regulates | hsa-mir-346 | represses | R-2481 | 20 | 20 | Drugs (1) |
| CMF-40600 | IDH1 | up-regulates | hsa-mir-153 | represses | R-2481 | 62 | 62 | Drugs (1) |
| CMF-40695 | IDH1 | up-regulates | hsa-mir-301 | represses | R-2481 | 37 | 32 | Drugs (1) |
| CMF-41229 | TP53 | up-regulates | hsa-mir-346 | represses | R-2481 | 20 | 20 | Drugs (1) |
| CMF-41273 | TP53 | up-regulates | hsa-mir-301 | represses | R-2481 | 37 | 28 | Drugs (1) |
| CMF-41603 | SFRS15 | down-regulates | hsa-mir-153 | represses | R-2481 | 62 | 13 | Drugs (1) |
| CMF-42149 | NAALADL1 | down-regulates | hsa-mir-346 | represses | R-2481 | 20 | 18 | Drugs (1) |
| CMF-42165 | NAALADL1 | down-regulates | hsa-mir-328 | represses | R-2481 | 27 | 7 | Drugs (1) |
| CMF-42187 | NAALADL1 | down-regulates | hsa-mir-301 | represses | R-2481 | 37 | 10 | Drugs (1) |
| CMF-42330 | SDK1 | down-regulates | hsa-mir-346 | represses | R-2481 | 20 | 14 | Drugs (1) |
| CMF-42342 | SDK1 | down-regulates | hsa-mir-328 | represses | R-2481 | 27 | 6 | Drugs (1) |
| CMF-42367 | SDK1 | down-regulates | hsa-mir-129 | represses | R-2481 | 155 | 22 | Drugs (1) |
| CMF-42539 | LCT | up-regulates | hsa-mir-331 | represses | R-2481 | 7 | 1 | Drugs (1) |
| CMF-42688 | IFT172 | up-regulates | hsa-mir-301 | represses | R-2481 | 37 | 7 | Drugs (1) |
| CMF-43188 | PRKDC | down-regulates | hsa-mir-346 | represses | R-2481 | 20 | 16 | Drugs (1) |
| CMF-43198 | PRKDC | down-regulates | hsa-mir-328 | represses | R-2481 | 27 | 1 | Drugs (1) |
| CMF-43270 | POLRMT | down-regulates | hsa-mir-346 | represses | R-2481 | 20 | 1 | Drugs (1) |
| CMF-43272 | POLRMT | down-regulates | hsa-mir-328 | represses | R-2481 | 27 | 11 | Drugs (1) |
CMFlow summary not available
Enrichment summary not available