Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
E2F2 - E2F transcription factor 2
Function
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 1870 | ENSG00000282899 | E2F2 | Q14209 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000282899 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-02901 | SRRM2 | down-regulates | E2F2 | represses | R-548 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-07948 | SLC27A2 | down-regulates | E2F2 | represses | R-548 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18250 | CDH19 | down-regulates | E2F2 | represses | R-548 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-24549 | SEMA3C | up-regulates | E2F2 | represses | R-548 | 3 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-31389 | ANGIOPOIETIN_RECEPTOR_TIE2_MEDIATED_SIGNALING | down-regulates | E2F2 | represses | R-548 | 3 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |