Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
SPIB - Spi-B transcription factor
Function
Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 6689 | ENSG00000269404 | SPIB | Q01892 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000269404 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01406 | UGGT1 | down-regulates | SPIB | activates | R-3629 | 4 | 1 | Drugs (3) |
| CMF-03007 | SPEF2 | down-regulates | SPIB | activates | R-3629 | 4 | 1 | Drugs (3) |
| CMF-05306 | PCSK6 | down-regulates | SPIB | activates | R-3629 | 4 | 1 | Drugs (3) |
| CMF-06048 | OTOA | down-regulates | SPIB | activates | R-3629 | 4 | 2 | Drugs (3) |
| CMF-06531 | SETD2 | down-regulates | SPIB | activates | R-3629 | 4 | 2 | Drugs (3) |
| CMF-07574 | AHNAK2 | down-regulates | SPIB | activates | R-3629 | 4 | 1 | Drugs (3) |
| CMF-08073 | TRIM6-TRIM34 | down-regulates | SPIB | activates | R-3629 | 4 | 1 | Drugs (3) |
| CMF-10158 | ANK2 | down-regulates | SPIB | activates | R-3629 | 4 | 1 | Drugs (3) |
| CMF-11585 | DNAH7 | down-regulates | SPIB | activates | R-3629 | 4 | 1 | Drugs (3) |
| CMF-15032 | TG | down-regulates | SPIB | activates | R-3629 | 4 | 1 | Drugs (3) |
| CMF-15853 | ZNF845 | down-regulates | SPIB | activates | R-3629 | 4 | 2 | Drugs (3) |
| CMF-17395 | TBC1D8 | down-regulates | SPIB | activates | R-3629 | 4 | 1 | Drugs (3) |
| CMF-17777 | C3 | down-regulates | SPIB | activates | R-3629 | 4 | 2 | Drugs (3) |
| CMF-18018 | PRPF40B | down-regulates | SPIB | activates | R-3629 | 4 | 1 | Drugs (3) |
| CMF-19614 | BRCA1 | down-regulates | SPIB | activates | R-3629 | 4 | 1 | Drugs (3) |
| CMF-22721 | IDH1 | down-regulates | SPIB | activates | R-3629 | 4 | 4 | Drugs (3) |
| CMF-23053 | AOX1 | down-regulates | SPIB | activates | R-3629 | 4 | 2 | Drugs (3) |
| CMF-26219 | CARD11 | down-regulates | SPIB | activates | R-3629 | 4 | 1 | Drugs (3) |
| CMF-26752 | RB1 | up-regulates | SPIB | activates | R-3629 | 4 | 2 | Drugs (3) |
| CMF-28550 | SNTG2 | down-regulates | SPIB | activates | R-3629 | 4 | 1 | Drugs (3) |
| CMF-31149 | LRFN2 | down-regulates | SPIB | activates | R-3629 | 4 | 2 | Drugs (3) |