Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

PAX5 - paired box 5

Function

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Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
5079 ENSG00000196092 PAX5 E7ERK2

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000196092 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-02331ERGdown-regulatesPAX5repressesR-35262Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-05131NEBdown-regulatesPAX5repressesR-35061Drugs (20)
CMF-06123HTR5Adown-regulatesPAX5repressesR-35261Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-07455THOC2down-regulatesPAX5repressesR-35261Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-09101TLL2down-regulatesPAX5repressesR-35261Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-09305HCLS1down-regulatesPAX5repressesR-35261Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-11218NRKdown-regulatesPAX5repressesR-35261Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-14644C1orf177down-regulatesPAX5repressesR-35061Drugs (20)
CMF-16762CPNE8down-regulatesPAX5repressesR-35061Drugs (20)
CMF-21428GRIK3down-regulatesPAX5repressesR-35263Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-24072TP53up-regulatesPAX5repressesR-35064Drugs (20)
CMF-24075TP53up-regulatesPAX5repressesR-35264Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-24687UGT2A3down-regulatesPAX5repressesR-35261Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-26605NAALADL1down-regulatesPAX5repressesR-35063Drugs (20)
CMF-27480SDK1down-regulatesPAX5repressesR-35061Drugs (20)
CMF-27659ANKRD36down-regulatesPAX5repressesR-35063Drugs (20)
CMF-28029AMPD1down-regulatesPAX5repressesR-35061Drugs (20)