Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
IKZF1 - IKAROS family zinc finger 1
Function
Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 10320 | ENSG00000185811 | IKZF1 | Q13422 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000185811 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01623 | MCM6 | up-regulates | IKZF1 | activates | R-3137 | 16 | 6 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-01624 | MCM6 | up-regulates | IKZF1 | activates | R-3133 | 16 | 6 | Drugs (1) |
| CMF-01625 | MCM6 | up-regulates | IKZF1 | activates | R-3135 | 16 | 6 | Drugs (2) |
| CMF-01626 | MCM6 | up-regulates | IKZF1 | activates | R-3134 | 16 | 6 | Drugs (1) |
| CMF-01627 | MCM6 | up-regulates | IKZF1 | activates | R-3138 | 16 | 6 | Drugs (5) |
| CMF-02794 | DHX30 | up-regulates | IKZF1 | activates | R-3137 | 16 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-02796 | DHX30 | up-regulates | IKZF1 | activates | R-3138 | 16 | 4 | Drugs (5) |
| CMF-03091 | LAMA3 | down-regulates | IKZF1 | activates | R-3137 | 16 | 1 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-04566 | LAMC3 | down-regulates | IKZF1 | activates | R-3137 | 16 | 5 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-04567 | LAMC3 | down-regulates | IKZF1 | activates | R-3135 | 16 | 5 | Drugs (2) |
| CMF-04568 | LAMC3 | down-regulates | IKZF1 | activates | R-3140 | 16 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04570 | LAMC3 | down-regulates | IKZF1 | activates | R-3138 | 16 | 5 | Drugs (5) |
| CMF-05908 | BCL6 | up-regulates | IKZF1 | activates | R-3135 | 16 | 2 | Drugs (2) |
| CMF-06529 | SETD2 | down-regulates | IKZF1 | activates | R-3138 | 16 | 2 | Drugs (5) |
| CMF-07572 | AHNAK2 | down-regulates | IKZF1 | activates | R-3134 | 16 | 2 | Drugs (1) |
| CMF-08287 | KIF4A | down-regulates | IKZF1 | activates | R-3137 | 16 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-08288 | KIF4A | down-regulates | IKZF1 | activates | R-3133 | 16 | 4 | Drugs (1) |
| CMF-08289 | KIF4A | down-regulates | IKZF1 | activates | R-3140 | 16 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-08290 | KIF4A | down-regulates | IKZF1 | activates | R-3138 | 16 | 4 | Drugs (5) |
| CMF-10068 | ATP8A2 | down-regulates | IKZF1 | activates | R-3135 | 16 | 3 | Drugs (2) |
| CMF-10069 | ATP8A2 | down-regulates | IKZF1 | activates | R-3134 | 16 | 3 | Drugs (1) |
| CMF-10070 | ATP8A2 | down-regulates | IKZF1 | activates | R-3138 | 16 | 3 | Drugs (5) |
| CMF-10876 | GOLGA6L10 | down-regulates | IKZF1 | activates | R-3140 | 16 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-10887 | SMARCA2 | up-regulates | IKZF1 | activates | R-3134 | 16 | 3 | Drugs (1) |
| CMF-10888 | SMARCA2 | up-regulates | IKZF1 | activates | R-3138 | 16 | 3 | Drugs (5) |
| CMF-10973 | BMP5 | down-regulates | IKZF1 | activates | R-3137 | 16 | 6 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-10976 | BMP5 | down-regulates | IKZF1 | activates | R-3134 | 16 | 6 | Drugs (1) |
| CMF-11134 | MYO18A | down-regulates | IKZF1 | activates | R-3137 | 16 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-11135 | MYO18A | down-regulates | IKZF1 | activates | R-3135 | 16 | 3 | Drugs (2) |
| CMF-11421 | CYP4F22 | up-regulates | IKZF1 | activates | R-3137 | 16 | 5 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-11423 | CYP4F22 | up-regulates | IKZF1 | activates | R-3134 | 16 | 5 | Drugs (1) |
| CMF-11424 | CYP4F22 | up-regulates | IKZF1 | activates | R-3138 | 16 | 5 | Drugs (5) |
| CMF-12313 | GPR98 | down-regulates | IKZF1 | activates | R-3137 | 16 | 9 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-12314 | GPR98 | down-regulates | IKZF1 | activates | R-3135 | 16 | 9 | Drugs (2) |
| CMF-12316 | GPR98 | down-regulates | IKZF1 | activates | R-3140 | 16 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12319 | GPR98 | down-regulates | IKZF1 | activates | R-3138 | 16 | 9 | Drugs (5) |
| CMF-12612 | SLCO6A1 | down-regulates | IKZF1 | activates | R-3135 | 16 | 3 | Drugs (2) |
| CMF-13825 | ADAMTS8 | down-regulates | IKZF1 | activates | R-3137 | 16 | 5 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-13826 | ADAMTS8 | down-regulates | IKZF1 | activates | R-3135 | 16 | 5 | Drugs (2) |
| CMF-13828 | ADAMTS8 | down-regulates | IKZF1 | activates | R-3134 | 16 | 5 | Drugs (1) |
| CMF-13970 | REM1 | up-regulates | IKZF1 | activates | R-3140 | 16 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13978 | CDKN2C | up-regulates | IKZF1 | activates | R-3137 | 16 | 3 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-13979 | CDKN2C | up-regulates | IKZF1 | activates | R-3135 | 16 | 3 | Drugs (2) |
| CMF-14038 | CEACAM20 | down-regulates | IKZF1 | activates | R-3138 | 16 | 2 | Drugs (5) |
| CMF-15738 | FN1 | up-regulates | IKZF1 | activates | R-3133 | 16 | 2 | Drugs (1) |
| CMF-15851 | ZNF845 | down-regulates | IKZF1 | activates | R-3134 | 16 | 2 | Drugs (1) |
| CMF-15952 | KCNB2 | up-regulates | IKZF1 | activates | R-3134 | 16 | 1 | Drugs (1) |
| CMF-16753 | CPNE8 | up-regulates | IKZF1 | activates | R-3140 | 16 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-16754 | CPNE8 | up-regulates | IKZF1 | activates | R-3134 | 16 | 2 | Drugs (1) |
| CMF-16861 | OR5I1 | down-regulates | IKZF1 | activates | R-3137 | 16 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-16862 | OR5I1 | down-regulates | IKZF1 | activates | R-3135 | 16 | 4 | Drugs (2) |
| CMF-16864 | OR5I1 | down-regulates | IKZF1 | activates | R-3138 | 16 | 4 | Drugs (5) |
| CMF-17545 | CNTNAP3 | up-regulates | IKZF1 | activates | R-3138 | 16 | 3 | Drugs (5) |
| CMF-19659 | RPSAP58 | up-regulates | IKZF1 | activates | R-3137 | 16 | 8 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-19660 | RPSAP58 | up-regulates | IKZF1 | activates | R-3135 | 16 | 8 | Drugs (2) |
| CMF-19662 | RPSAP58 | up-regulates | IKZF1 | activates | R-3134 | 16 | 8 | Drugs (1) |
| CMF-19663 | RPSAP58 | up-regulates | IKZF1 | activates | R-3138 | 16 | 8 | Drugs (5) |
| CMF-20134 | TDRD9 | up-regulates | IKZF1 | activates | R-3137 | 16 | 5 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-20135 | TDRD9 | up-regulates | IKZF1 | activates | R-3133 | 16 | 5 | Drugs (1) |
| CMF-20136 | TDRD9 | up-regulates | IKZF1 | activates | R-3135 | 16 | 5 | Drugs (2) |
| CMF-20138 | TDRD9 | up-regulates | IKZF1 | activates | R-3134 | 16 | 5 | Drugs (1) |
| CMF-20178 | KIAA1598 | up-regulates | IKZF1 | activates | R-3133 | 16 | 2 | Drugs (1) |
| CMF-20921 | STAB2 | down-regulates | IKZF1 | activates | R-3134 | 16 | 1 | Drugs (1) |
| CMF-21672 | MUC17 | up-regulates | IKZF1 | activates | R-3137 | 16 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-21673 | MUC17 | up-regulates | IKZF1 | activates | R-3133 | 16 | 4 | Drugs (1) |
| CMF-21674 | MUC17 | up-regulates | IKZF1 | activates | R-3135 | 16 | 4 | Drugs (2) |
| CMF-21675 | MUC17 | up-regulates | IKZF1 | activates | R-3134 | 16 | 4 | Drugs (1) |
| CMF-24249 | OR5D18 | down-regulates | IKZF1 | activates | R-3134 | 16 | 1 | Drugs (1) |
| CMF-24866 | NSUN5 | down-regulates | IKZF1 | activates | R-3137 | 16 | 5 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BI-505, OBATOCLAX MESYLATE, OBATOCLAX, HCBE-11, AVDORALIMAB, AVACOPAN, ALICAFORSEN |
| CMF-24867 | NSUN5 | down-regulates | IKZF1 | activates | R-3135 | 16 | 5 | Drugs (2) |
| CMF-24869 | NSUN5 | down-regulates | IKZF1 | activates | R-3134 | 16 | 5 | Drugs (1) |
| CMF-27631 | ANKRD36 | up-regulates | IKZF1 | activates | R-3133 | 16 | 5 | Drugs (1) |
| CMF-27632 | ANKRD36 | up-regulates | IKZF1 | activates | R-3135 | 16 | 5 | Drugs (2) |
| CMF-27633 | ANKRD36 | up-regulates | IKZF1 | activates | R-3140 | 16 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27634 | ANKRD36 | up-regulates | IKZF1 | activates | R-3134 | 16 | 5 | Drugs (1) |
| CMF-29268 | ITGAM | down-regulates | IKZF1 | activates | R-3133 | 16 | 1 | Drugs (1) |
| CMF-29366 | UHRF1BP1L | down-regulates | IKZF1 | activates | R-3140 | 16 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30538 | JHDM1D | down-regulates | IKZF1 | activates | R-3140 | 16 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-30539 | JHDM1D | down-regulates | IKZF1 | activates | R-3143 | 16 | 2 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)MERIMEPODIB, MYCOPHENOLATE MOFETIL, MIZORIBINE, AVN-944, MYCOPHENOLIC ACID, MARIMASTAT, THIOGUANINE, TOSEDOSTAT, RIBAVIRIN |