Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

SP1 - Sp1 transcription factor

Function

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21798247, PubMed:21046154). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity).

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
6667 ENSG00000185591 SP1 P08047

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000185591 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-00105LRP2up-regulatesSP1activatesR-137682Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-00168SCN9Adown-regulatesSP1activatesR-137681Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-00415NF1up-regulatesSP1activatesR-137682Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-01967PCDH9down-regulatesSP1activatesR-137681Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-02252GPR65up-regulatesSP1activatesR-137681Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-02951ADCY5down-regulatesSP1repressesR-137085Drugs (120)

Regulator Drugs (0)

Regulon Drugs (120)

ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB

CMF-02955ADCY5down-regulatesSP1repressesR-137385Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-03075SFRS2IPup-regulatesSP1repressesR-137081Drugs (120)

Regulator Drugs (0)

Regulon Drugs (120)

ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB

CMF-04281RBPJLup-regulatesSP1repressesR-137082Drugs (120)

Regulator Drugs (0)

Regulon Drugs (120)

ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB

CMF-04282RBPJLup-regulatesSP1repressesR-137382Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-05927CACNA1Eup-regulatesSP1repressesR-137082Drugs (120)

Regulator Drugs (0)

Regulon Drugs (120)

ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB

CMF-06196MYO5Bup-regulatesSP1repressesR-137081Drugs (120)

Regulator Drugs (0)

Regulon Drugs (120)

ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB

CMF-07675SAMD9Ldown-regulatesSP1activatesR-137682Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-07960F5up-regulatesSP1repressesR-137383Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-08980GPR132up-regulatesSP1activatesR-137681Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-10472LPAup-regulatesSP1repressesR-137082Drugs (120)

Regulator Drugs (0)

Regulon Drugs (120)

ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB

CMF-10766UGT2B10down-regulatesSP1repressesR-137381Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-11478SPENup-regulatesSP1repressesR-137081Drugs (120)

Regulator Drugs (0)

Regulon Drugs (120)

ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB

CMF-11555PREX2up-regulatesSP1repressesR-137081Drugs (120)

Regulator Drugs (0)

Regulon Drugs (120)

ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB

CMF-12431HSPG2up-regulatesSP1repressesR-137081Drugs (120)

Regulator Drugs (0)

Regulon Drugs (120)

ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB

CMF-12816UNC5Cup-regulatesSP1repressesR-137381Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-16240USP11down-regulatesSP1repressesR-137381Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-16887CR2up-regulatesSP1repressesR-137383Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-17835CSF2RBup-regulatesSP1repressesR-137085Drugs (120)

Regulator Drugs (0)

Regulon Drugs (120)

ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB

CMF-17836CSF2RBup-regulatesSP1activatesR-137685Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-18587CNTNAP2down-regulatesSP1repressesR-137383Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-18758LY75up-regulatesSP1repressesR-137382Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-20440CUX2up-regulatesSP1activatesR-137681Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-20901CD3EAPup-regulatesSP1repressesR-137381Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-23310CD44up-regulatesSP1repressesR-137081Drugs (120)

Regulator Drugs (0)

Regulon Drugs (120)

ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB

CMF-24576KIF16Bdown-regulatesSP1repressesR-137382Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-25151FLT3up-regulatesSP1repressesR-137082Drugs (120)

Regulator Drugs (0)

Regulon Drugs (120)

ERIBULIN MESYLATE, SAGOPILONE, AGS-16C3F, TERODILINE, TELISOTUZUMAB VEDOTIN, ACAMPROSATE CALCIUM, DOCETAXEL, FOSBRETABULIN DISODIUM, CHF-6001, VINCRISTINE, VINFLUNINE, AV-101, LEXIBULIN, VINCRISTINE SULFATE, TRASTUZUMAB EMTANSINE, ENFORTUMAB VEDOTIN, MEMANTINE, VINORELBINE TARTRATE, LIFASTUZUMAB VEDOTIN, KOS-1584, APREMILAST, PRALUZATAMAB RAVTANSINE, DYPHYLLINE, OGLEMILAST, LADIRATUZUMAB VEDOTIN, MEMANTINE HYDROCHLORIDE, FLAVOXATE HYDROCHLORIDE, PACLITAXEL, ORPHENADRINE HYDROCHLORIDE, CROLIBULIN, MK-0873, TOFIMILAST, PACLITAXEL POLIGLUMEX, PATUPILONE, PENTOXIFYLLINE, ASG-5ME, ANG1005, DROTAVERINE, CEP-1347, PINATUZUMAB VEDOTIN, DIPYRIDAMOLE, VERUBULIN, VINBLASTINE SULFATE, VINORELBINE, DEFACTINIB, DAVUNETIDE, BELANTAMAB MAFODOTIN, FOSBRETABULIN, TRAXOPRODIL, NERAMEXANE, EVT-101, KETAMINE, IBUDILAST, MIRVETUXIMAB SORAVTANSINE, GSK-256066, ROFLUMILAST, IXABEPILONE, POLATUZUMAB VEDOTIN, ORPHENADRINE, T-900607, DIFAMILAST, APRUTUMAB IXADOTIN, PLINABULIN, GABAPENTIN ENACARBIL, TISOTUMAB VEDOTIN, DOLASTATIN-10, FOSBRETABULIN TROMETHAMINE, CILOMILAST, SAR-408701, FELBAMATE, CABAZITAXEL, FLAVOXATE, AMANTADINE HYDROCHLORIDE, PACLITAXEL DOCOSAHEXAENOIC ACID, PREGABALIN, RAPASTINEL, ATAGABALIN, GABAPENTIN, ERIBULIN, BMS-275183, INDUSATUMAB VEDOTIN, LANICEMINE, CRISABOROLE, RISLENEMDAZ, GLEMBATUMUMAB VEDOTIN, COLCHICINE, ACAMPROSATE, RALFINAMIDE, VANDORTUZUMAB VEDOTIN, VINBLASTINE, BEPRIDIL, BRENTUXIMAB VEDOTIN, SULOCTIDIL, GW468816, NERAMEXANE MESYLATE, IMAGABALIN, TETOMILAST, AMLEXANOX, EPOTHILONE D, SOFITUZUMAB VEDOTIN, INDIBULIN, ORPHENADRINE CITRATE, OXTRIPHYLLINE, RADIPRODIL, AZINTUXIZUMAB VEDOTIN, APIMOSTINEL, HT-0712, ESKETAMINE, INDANTADOL, LOTAMILAST, ESKETAMINE HYDROCHLORIDE, LAROTAXEL, RG-7841, AMANTADINE, CC-11050, LORVOTUZUMAB MERTANSINE, THEOPHYLLINE, KETAMINE HYDROCHLORIDE, AMINOPHYLLINE, CONTELTINIB

CMF-25152FLT3up-regulatesSP1activatesR-137682Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-25448PCDHGB3up-regulatesSP1repressesR-137382Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-25607COL6A6up-regulatesSP1repressesR-137381Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-26595NAALADL1up-regulatesSP1repressesR-137383Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-28425MYO9Bdown-regulatesSP1activatesR-137681Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-29070DNAH3up-regulatesSP1activatesR-137682Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-29071DNAH3up-regulatesSP1repressesR-137382Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-29215AQP10down-regulatesSP1activatesR-137682Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-30205OR4K13down-regulatesSP1activatesR-137681Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-31471SIGNALING_EVENTS_MEDIATED_BY_TCPTPup-regulatesSP1activatesR-137681Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-31566EGF_RECEPTOR_SIGNALING_PATHWAYup-regulatesSP1activatesR-137681Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-32119A6B1_AND_A6B4_INTEGRIN_SIGNALINGup-regulatesSP1activatesR-137681Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-32822E_CADHERIN_SIGNALING_IN_KERATINOCYTESup-regulatesSP1activatesR-137681Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB

CMF-33358ERBB1_DOWNSTREAM_SIGNALINGup-regulatesSP1activatesR-137681Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

VANTICTUMAB