Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
SATB1 - SATB homeobox 1
Function
Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 6304 | ENSG00000182568 | SATB1 | Q01826 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000182568 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00764 | TPTE2 | up-regulates | SATB1 | represses | R-1681 | 24 | 1 | Drugs (23) Regulator Drugs (0)Regulon Drugs (23)TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-00799 | MUC2 | down-regulates | SATB1 | activates | R-1693 | 24 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-00800 | MUC2 | down-regulates | SATB1 | activates | R-1682 | 24 | 7 | Drugs (2) |
| CMF-00801 | MUC2 | down-regulates | SATB1 | activates | R-1694 | 24 | 7 | Drugs (1) |
| CMF-01454 | MTOR | down-regulates | SATB1 | represses | R-1680 | 24 | 5 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-01595 | MCM6 | down-regulates | SATB1 | activates | R-1693 | 24 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01596 | MCM6 | down-regulates | SATB1 | represses | R-1679 | 24 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01597 | MCM6 | down-regulates | SATB1 | represses | R-1676 | 24 | 3 | Drugs (4) |
| CMF-01684 | SGOL2 | down-regulates | SATB1 | activates | R-1693 | 24 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01685 | SGOL2 | down-regulates | SATB1 | represses | R-1684 | 24 | 4 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ABRILUMAB, DOXYCYCLINE ANHYDROUS, DOXYCYCLINE, NATALIZUMAB, DOXYCYCLINE HYCLATE, FIRATEGRAST, VEDOLIZUMAB, DOXYCYCLINE CALCIUM, MARIMASTAT |
| CMF-02616 | LBP | down-regulates | SATB1 | activates | R-1682 | 24 | 3 | Drugs (2) |
| CMF-02748 | BCAM | up-regulates | SATB1 | activates | R-1682 | 24 | 4 | Drugs (2) |
| CMF-03156 | WDR90 | up-regulates | SATB1 | represses | R-1679 | 24 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03160 | WDR90 | up-regulates | SATB1 | represses | R-1676 | 24 | 7 | Drugs (4) |
| CMF-03190 | GCC2 | up-regulates | SATB1 | represses | R-1681 | 24 | 1 | Drugs (23) Regulator Drugs (0)Regulon Drugs (23)TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-03574 | RGS12 | up-regulates | SATB1 | activates | R-1693 | 24 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-03575 | RGS12 | up-regulates | SATB1 | activates | R-1682 | 24 | 8 | Drugs (2) |
| CMF-04512 | LAMC3 | up-regulates | SATB1 | activates | R-1693 | 24 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-04513 | LAMC3 | up-regulates | SATB1 | represses | R-1680 | 24 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-04709 | ADAMTS7 | up-regulates | SATB1 | activates | R-1682 | 24 | 3 | Drugs (2) |
| CMF-06461 | LGSN | up-regulates | SATB1 | activates | R-1694 | 24 | 4 | Drugs (1) |
| CMF-06577 | RLTPR | down-regulates | SATB1 | activates | R-1693 | 24 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06578 | RLTPR | down-regulates | SATB1 | activates | R-1682 | 24 | 4 | Drugs (2) |
| CMF-06713 | ATRX | up-regulates | SATB1 | activates | R-1693 | 24 | 15 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06716 | ATRX | up-regulates | SATB1 | represses | R-1679 | 24 | 15 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06717 | ATRX | up-regulates | SATB1 | activates | R-1682 | 24 | 15 | Drugs (2) |
| CMF-06718 | ATRX | up-regulates | SATB1 | represses | R-1680 | 24 | 15 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-06719 | ATRX | up-regulates | SATB1 | represses | R-1684 | 24 | 15 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ABRILUMAB, DOXYCYCLINE ANHYDROUS, DOXYCYCLINE, NATALIZUMAB, DOXYCYCLINE HYCLATE, FIRATEGRAST, VEDOLIZUMAB, DOXYCYCLINE CALCIUM, MARIMASTAT |
| CMF-06720 | ATRX | up-regulates | SATB1 | activates | R-1694 | 24 | 15 | Drugs (1) |
| CMF-06723 | ATRX | up-regulates | SATB1 | represses | R-1676 | 24 | 15 | Drugs (4) |
| CMF-06724 | ATRX | up-regulates | SATB1 | represses | R-1681 | 24 | 15 | Drugs (23) Regulator Drugs (0)Regulon Drugs (23)TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-07387 | THOC2 | down-regulates | SATB1 | represses | R-1680 | 24 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-08371 | C9orf131 | down-regulates | SATB1 | activates | R-1682 | 24 | 4 | Drugs (2) |
| CMF-08372 | C9orf131 | down-regulates | SATB1 | activates | R-1694 | 24 | 4 | Drugs (1) |
| CMF-09810 | ABP1 | down-regulates | SATB1 | activates | R-1682 | 24 | 4 | Drugs (2) |
| CMF-11244 | OR5W2 | down-regulates | SATB1 | represses | R-1681 | 24 | 6 | Drugs (23) Regulator Drugs (0)Regulon Drugs (23)TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-11536 | PREX2 | down-regulates | SATB1 | activates | R-1694 | 24 | 2 | Drugs (1) |
| CMF-11782 | DNAH17 | up-regulates | SATB1 | activates | R-1682 | 24 | 5 | Drugs (2) |
| CMF-11785 | DNAH17 | up-regulates | SATB1 | activates | R-1694 | 24 | 5 | Drugs (1) |
| CMF-15718 | FN1 | down-regulates | SATB1 | represses | R-1676 | 24 | 2 | Drugs (4) |
| CMF-16306 | PRG4 | up-regulates | SATB1 | activates | R-1694 | 24 | 2 | Drugs (1) |
| CMF-16519 | OR9G4 | down-regulates | SATB1 | represses | R-1676 | 24 | 2 | Drugs (4) |
| CMF-16879 | CR2 | up-regulates | SATB1 | activates | R-1694 | 24 | 1 | Drugs (1) |
| CMF-16898 | TIE1 | up-regulates | SATB1 | activates | R-1694 | 24 | 2 | Drugs (1) |
| CMF-17512 | CNTNAP3 | down-regulates | SATB1 | represses | R-1679 | 24 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17513 | CNTNAP3 | down-regulates | SATB1 | activates | R-1682 | 24 | 2 | Drugs (2) |
| CMF-17920 | PRPF40B | up-regulates | SATB1 | represses | R-1679 | 24 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17921 | PRPF40B | up-regulates | SATB1 | represses | R-1684 | 24 | 9 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ABRILUMAB, DOXYCYCLINE ANHYDROUS, DOXYCYCLINE, NATALIZUMAB, DOXYCYCLINE HYCLATE, FIRATEGRAST, VEDOLIZUMAB, DOXYCYCLINE CALCIUM, MARIMASTAT |
| CMF-17924 | PRPF40B | up-regulates | SATB1 | represses | R-1681 | 24 | 9 | Drugs (23) Regulator Drugs (0)Regulon Drugs (23)TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-18530 | OR5D16 | up-regulates | SATB1 | activates | R-1693 | 24 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-18531 | OR5D16 | up-regulates | SATB1 | activates | R-1682 | 24 | 7 | Drugs (2) |
| CMF-18533 | OR5D16 | up-regulates | SATB1 | activates | R-1694 | 24 | 7 | Drugs (1) |
| CMF-18555 | FAM86D | up-regulates | SATB1 | represses | R-1684 | 24 | 2 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ABRILUMAB, DOXYCYCLINE ANHYDROUS, DOXYCYCLINE, NATALIZUMAB, DOXYCYCLINE HYCLATE, FIRATEGRAST, VEDOLIZUMAB, DOXYCYCLINE CALCIUM, MARIMASTAT |
| CMF-19227 | NF1 | down-regulates | SATB1 | activates | R-1693 | 24 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-19229 | NF1 | down-regulates | SATB1 | represses | R-1679 | 24 | 9 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-19230 | NF1 | down-regulates | SATB1 | represses | R-1684 | 24 | 9 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ABRILUMAB, DOXYCYCLINE ANHYDROUS, DOXYCYCLINE, NATALIZUMAB, DOXYCYCLINE HYCLATE, FIRATEGRAST, VEDOLIZUMAB, DOXYCYCLINE CALCIUM, MARIMASTAT |
| CMF-19233 | NF1 | down-regulates | SATB1 | represses | R-1676 | 24 | 9 | Drugs (4) |
| CMF-19234 | NF1 | down-regulates | SATB1 | represses | R-1681 | 24 | 9 | Drugs (23) Regulator Drugs (0)Regulon Drugs (23)TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-20541 | ADCY1 | down-regulates | SATB1 | activates | R-1693 | 24 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20543 | ADCY1 | down-regulates | SATB1 | represses | R-1680 | 24 | 8 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-20544 | ADCY1 | down-regulates | SATB1 | represses | R-1684 | 24 | 8 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ABRILUMAB, DOXYCYCLINE ANHYDROUS, DOXYCYCLINE, NATALIZUMAB, DOXYCYCLINE HYCLATE, FIRATEGRAST, VEDOLIZUMAB, DOXYCYCLINE CALCIUM, MARIMASTAT |
| CMF-20547 | ADCY1 | down-regulates | SATB1 | represses | R-1676 | 24 | 8 | Drugs (4) |
| CMF-20628 | ABCD2 | down-regulates | SATB1 | activates | R-1693 | 24 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-20629 | ABCD2 | down-regulates | SATB1 | activates | R-1682 | 24 | 3 | Drugs (2) |
| CMF-22322 | IDH1 | up-regulates | SATB1 | activates | R-1693 | 24 | 18 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22325 | IDH1 | up-regulates | SATB1 | represses | R-1679 | 24 | 18 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22326 | IDH1 | up-regulates | SATB1 | activates | R-1682 | 24 | 18 | Drugs (2) |
| CMF-22328 | IDH1 | up-regulates | SATB1 | represses | R-1680 | 24 | 18 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-22329 | IDH1 | up-regulates | SATB1 | represses | R-1684 | 24 | 18 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ABRILUMAB, DOXYCYCLINE ANHYDROUS, DOXYCYCLINE, NATALIZUMAB, DOXYCYCLINE HYCLATE, FIRATEGRAST, VEDOLIZUMAB, DOXYCYCLINE CALCIUM, MARIMASTAT |
| CMF-22330 | IDH1 | up-regulates | SATB1 | activates | R-1694 | 24 | 18 | Drugs (1) |
| CMF-22335 | IDH1 | up-regulates | SATB1 | represses | R-1676 | 24 | 18 | Drugs (4) |
| CMF-22336 | IDH1 | up-regulates | SATB1 | represses | R-1681 | 24 | 18 | Drugs (23) Regulator Drugs (0)Regulon Drugs (23)TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-23610 | TP53 | up-regulates | SATB1 | activates | R-1693 | 24 | 17 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23613 | TP53 | up-regulates | SATB1 | represses | R-1679 | 24 | 17 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-23614 | TP53 | up-regulates | SATB1 | activates | R-1682 | 24 | 17 | Drugs (2) |
| CMF-23615 | TP53 | up-regulates | SATB1 | represses | R-1680 | 24 | 17 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-23617 | TP53 | up-regulates | SATB1 | activates | R-1694 | 24 | 17 | Drugs (1) |
| CMF-23621 | TP53 | up-regulates | SATB1 | represses | R-1676 | 24 | 17 | Drugs (4) |
| CMF-23622 | TP53 | up-regulates | SATB1 | represses | R-1681 | 24 | 17 | Drugs (23) Regulator Drugs (0)Regulon Drugs (23)TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-25207 | KIF13A | up-regulates | SATB1 | represses | R-1681 | 24 | 1 | Drugs (23) Regulator Drugs (0)Regulon Drugs (23)TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-25810 | CD163 | up-regulates | SATB1 | activates | R-1693 | 24 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25812 | CD163 | up-regulates | SATB1 | represses | R-1680 | 24 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-25908 | MMP13 | down-regulates | SATB1 | represses | R-1681 | 24 | 1 | Drugs (23) Regulator Drugs (0)Regulon Drugs (23)TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-26058 | MST1P9 | up-regulates | SATB1 | activates | R-1694 | 24 | 6 | Drugs (1) |
| CMF-26460 | EGFR | down-regulates | SATB1 | activates | R-1682 | 24 | 2 | Drugs (2) |
| CMF-26727 | RB1 | down-regulates | SATB1 | activates | R-1694 | 24 | 5 | Drugs (1) |
| CMF-27568 | ANKRD36 | down-regulates | SATB1 | represses | R-1679 | 24 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27569 | ANKRD36 | down-regulates | SATB1 | represses | R-1680 | 24 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-27570 | ANKRD36 | down-regulates | SATB1 | represses | R-1684 | 24 | 7 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ABRILUMAB, DOXYCYCLINE ANHYDROUS, DOXYCYCLINE, NATALIZUMAB, DOXYCYCLINE HYCLATE, FIRATEGRAST, VEDOLIZUMAB, DOXYCYCLINE CALCIUM, MARIMASTAT |
| CMF-27571 | ANKRD36 | down-regulates | SATB1 | represses | R-1676 | 24 | 7 | Drugs (4) |
| CMF-27572 | ANKRD36 | down-regulates | SATB1 | represses | R-1681 | 24 | 7 | Drugs (23) Regulator Drugs (0)Regulon Drugs (23)TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-27757 | CSMD3 | down-regulates | SATB1 | activates | R-1693 | 24 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-27758 | CSMD3 | down-regulates | SATB1 | activates | R-1682 | 24 | 3 | Drugs (2) |
| CMF-28056 | CELSR3 | up-regulates | SATB1 | activates | R-1693 | 24 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-28057 | CELSR3 | up-regulates | SATB1 | represses | R-1684 | 24 | 5 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ABRILUMAB, DOXYCYCLINE ANHYDROUS, DOXYCYCLINE, NATALIZUMAB, DOXYCYCLINE HYCLATE, FIRATEGRAST, VEDOLIZUMAB, DOXYCYCLINE CALCIUM, MARIMASTAT |
| CMF-28058 | CELSR3 | up-regulates | SATB1 | represses | R-1676 | 24 | 5 | Drugs (4) |
| CMF-28059 | CELSR3 | up-regulates | SATB1 | represses | R-1681 | 24 | 5 | Drugs (23) Regulator Drugs (0)Regulon Drugs (23)TRELAGLIPTIN SUCCINATE, TD-139, VILDAGLIPTIN, DAVANAT, ALOGLIPTIN BENZOATE, SAXAGLIPTIN, ANAGLIPTIN, TENELIGLIPTIN, CARMEGLIPTIN, BEGELOMAB, OMARIGLIPTIN, SAXAGLIPTIN HYDROCHLORIDE, GEMIGLIPTIN, BISEGLIPTIN, SITAGLIPTIN, DUTOGLIPTIN, EVOGLIPTIN, ALOGLIPTIN, BELAPECTIN, LINAGLIPTIN, TRELAGLIPTIN, GOSOGLIPTIN, SITAGLIPTIN PHOSPHATE |
| CMF-28389 | MYO9B | up-regulates | SATB1 | represses | R-1684 | 24 | 4 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ABRILUMAB, DOXYCYCLINE ANHYDROUS, DOXYCYCLINE, NATALIZUMAB, DOXYCYCLINE HYCLATE, FIRATEGRAST, VEDOLIZUMAB, DOXYCYCLINE CALCIUM, MARIMASTAT |
| CMF-28391 | MYO9B | up-regulates | SATB1 | represses | R-1676 | 24 | 4 | Drugs (4) |
| CMF-29162 | AQP10 | up-regulates | SATB1 | activates | R-1693 | 24 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29165 | AQP10 | up-regulates | SATB1 | represses | R-1679 | 24 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29166 | AQP10 | up-regulates | SATB1 | represses | R-1680 | 24 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)BINTRAFUSP ALFA, TRABEDERSEN, LUSPATERCEPT, SULTHIAME, FRESOLIMUMAB, TOSEDOSTAT, BIVATUZUMAB |
| CMF-29168 | AQP10 | up-regulates | SATB1 | represses | R-1676 | 24 | 7 | Drugs (4) |
| CMF-29579 | ESRRB | down-regulates | SATB1 | represses | R-1679 | 24 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-29581 | ESRRB | down-regulates | SATB1 | activates | R-1694 | 24 | 6 | Drugs (1) |