Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
STAT3 - signal transducer and activator of transcription 3
Function
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:22306293, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 6774 | ENSG00000168610 | STAT3 | P40763 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000168610 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-00517 | HMCN1 | up-regulates | STAT3 | activates | R-1535 | 25 | 10 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-00518 | HMCN1 | up-regulates | STAT3 | activates | R-1527 | 25 | 10 | Drugs (3) |
| CMF-00519 | HMCN1 | up-regulates | STAT3 | activates | R-1525 | 25 | 10 | Drugs (4) |
| CMF-00520 | HMCN1 | up-regulates | STAT3 | activates | R-1531 | 25 | 10 | Drugs (3) |
| CMF-00521 | HMCN1 | up-regulates | STAT3 | activates | R-1517 | 25 | 10 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, PEGINTERFERON LAMBDA-1A |
| CMF-00523 | HMCN1 | up-regulates | STAT3 | activates | R-1532 | 25 | 10 | Drugs (1) |
| CMF-01028 | ZNF292 | down-regulates | STAT3 | activates | R-1527 | 25 | 6 | Drugs (3) |
| CMF-01031 | ZNF292 | down-regulates | STAT3 | activates | R-1517 | 25 | 6 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, PEGINTERFERON LAMBDA-1A |
| CMF-01032 | ZNF292 | down-regulates | STAT3 | activates | R-1521 | 25 | 6 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-01447 | MTOR | up-regulates | STAT3 | activates | R-1532 | 25 | 5 | Drugs (1) |
| CMF-01786 | TMPRSS15 | up-regulates | STAT3 | activates | R-1535 | 25 | 6 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-01790 | TMPRSS15 | up-regulates | STAT3 | activates | R-1521 | 25 | 6 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-02383 | LRP2 | up-regulates | STAT3 | activates | R-1530 | 25 | 7 | Drugs (5) |
| CMF-02386 | LRP2 | up-regulates | STAT3 | activates | R-1521 | 25 | 7 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-02387 | LRP2 | up-regulates | STAT3 | activates | R-1532 | 25 | 7 | Drugs (1) |
| CMF-03027 | OR5D14 | up-regulates | STAT3 | activates | R-1530 | 25 | 4 | Drugs (5) |
| CMF-03029 | OR5D14 | up-regulates | STAT3 | activates | R-1521 | 25 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-03668 | DSP | up-regulates | STAT3 | activates | R-1535 | 25 | 7 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-03672 | DSP | up-regulates | STAT3 | activates | R-1539 | 25 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06624 | SCNN1G | down-regulates | STAT3 | activates | R-1532 | 25 | 2 | Drugs (1) |
| CMF-06668 | ATRX | down-regulates | STAT3 | activates | R-1530 | 25 | 17 | Drugs (5) |
| CMF-06670 | ATRX | down-regulates | STAT3 | activates | R-1535 | 25 | 17 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-06671 | ATRX | down-regulates | STAT3 | activates | R-1527 | 25 | 17 | Drugs (3) |
| CMF-06673 | ATRX | down-regulates | STAT3 | activates | R-1525 | 25 | 17 | Drugs (4) |
| CMF-06675 | ATRX | down-regulates | STAT3 | activates | R-1531 | 25 | 17 | Drugs (3) |
| CMF-06676 | ATRX | down-regulates | STAT3 | activates | R-1517 | 25 | 17 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, PEGINTERFERON LAMBDA-1A |
| CMF-06678 | ATRX | down-regulates | STAT3 | activates | R-1521 | 25 | 17 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-06679 | ATRX | down-regulates | STAT3 | activates | R-1539 | 25 | 17 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-06680 | ATRX | down-regulates | STAT3 | activates | R-1518 | 25 | 17 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-06681 | ATRX | down-regulates | STAT3 | activates | R-1532 | 25 | 17 | Drugs (1) |
| CMF-08573 | FOXR2 | down-regulates | STAT3 | activates | R-1530 | 25 | 6 | Drugs (5) |
| CMF-08574 | FOXR2 | down-regulates | STAT3 | activates | R-1527 | 25 | 6 | Drugs (3) |
| CMF-08678 | MYH14 | up-regulates | STAT3 | activates | R-1532 | 25 | 4 | Drugs (1) |
| CMF-08733 | FBLN2 | up-regulates | STAT3 | activates | R-1521 | 25 | 5 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-08735 | FBLN2 | up-regulates | STAT3 | activates | R-1528 | 25 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-09008 | NALCN | down-regulates | STAT3 | activates | R-1527 | 25 | 4 | Drugs (3) |
| CMF-09010 | NALCN | down-regulates | STAT3 | activates | R-1532 | 25 | 4 | Drugs (1) |
| CMF-09084 | TLL2 | up-regulates | STAT3 | activates | R-1535 | 25 | 4 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-09462 | DOCK11 | up-regulates | STAT3 | activates | R-1525 | 25 | 3 | Drugs (4) |
| CMF-10492 | LRBA | up-regulates | STAT3 | activates | R-1525 | 25 | 4 | Drugs (4) |
| CMF-10789 | HELZ | up-regulates | STAT3 | activates | R-1530 | 25 | 2 | Drugs (5) |
| CMF-11094 | ATF7IP2 | up-regulates | STAT3 | activates | R-1535 | 25 | 2 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-11385 | CYP4F22 | up-regulates | STAT3 | activates | R-1530 | 25 | 6 | Drugs (5) |
| CMF-11387 | CYP4F22 | up-regulates | STAT3 | activates | R-1517 | 25 | 6 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, PEGINTERFERON LAMBDA-1A |
| CMF-11389 | CYP4F22 | up-regulates | STAT3 | activates | R-1518 | 25 | 6 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-11780 | DNAH17 | down-regulates | STAT3 | activates | R-1535 | 25 | 1 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-11858 | PALM2-AKAP2 | up-regulates | STAT3 | activates | R-1532 | 25 | 3 | Drugs (1) |
| CMF-12199 | GPR98 | down-regulates | STAT3 | activates | R-1530 | 25 | 9 | Drugs (5) |
| CMF-12200 | GPR98 | down-regulates | STAT3 | activates | R-1527 | 25 | 9 | Drugs (3) |
| CMF-12203 | GPR98 | down-regulates | STAT3 | activates | R-1521 | 25 | 9 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-12204 | GPR98 | down-regulates | STAT3 | activates | R-1532 | 25 | 9 | Drugs (1) |
| CMF-13062 | OTC | up-regulates | STAT3 | activates | R-1521 | 25 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-13123 | SLC26A8 | up-regulates | STAT3 | activates | R-1521 | 25 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-13124 | SLC26A8 | up-regulates | STAT3 | activates | R-1528 | 25 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-13347 | FMN1 | up-regulates | STAT3 | activates | R-1530 | 25 | 6 | Drugs (5) |
| CMF-13351 | FMN1 | up-regulates | STAT3 | activates | R-1521 | 25 | 6 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-13352 | FMN1 | up-regulates | STAT3 | activates | R-1528 | 25 | 6 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-14177 | ZNF516 | up-regulates | STAT3 | activates | R-1535 | 25 | 5 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-14178 | ZNF516 | up-regulates | STAT3 | activates | R-1525 | 25 | 5 | Drugs (4) |
| CMF-14180 | ZNF516 | up-regulates | STAT3 | activates | R-1532 | 25 | 5 | Drugs (1) |
| CMF-15240 | HCN1 | up-regulates | STAT3 | activates | R-1530 | 25 | 4 | Drugs (5) |
| CMF-15242 | HCN1 | up-regulates | STAT3 | activates | R-1532 | 25 | 4 | Drugs (1) |
| CMF-15598 | DCHS2 | up-regulates | STAT3 | activates | R-1535 | 25 | 6 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-15599 | DCHS2 | up-regulates | STAT3 | activates | R-1527 | 25 | 6 | Drugs (3) |
| CMF-15600 | DCHS2 | up-regulates | STAT3 | activates | R-1531 | 25 | 6 | Drugs (3) |
| CMF-15601 | DCHS2 | up-regulates | STAT3 | activates | R-1532 | 25 | 6 | Drugs (1) |
| CMF-15999 | NFIX | up-regulates | STAT3 | activates | R-1518 | 25 | 4 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-16365 | SUSD5 | up-regulates | STAT3 | activates | R-1521 | 25 | 5 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-16693 | SI | up-regulates | STAT3 | activates | R-1532 | 25 | 1 | Drugs (1) |
| CMF-16765 | MACF1 | down-regulates | STAT3 | activates | R-1530 | 25 | 4 | Drugs (5) |
| CMF-16767 | MACF1 | down-regulates | STAT3 | activates | R-1521 | 25 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-17772 | C3 | down-regulates | STAT3 | activates | R-1527 | 25 | 1 | Drugs (3) |
| CMF-18433 | LAMA1 | up-regulates | STAT3 | activates | R-1532 | 25 | 4 | Drugs (1) |
| CMF-18968 | CLEC14A | up-regulates | STAT3 | activates | R-1527 | 25 | 4 | Drugs (3) |
| CMF-18969 | CLEC14A | up-regulates | STAT3 | activates | R-1525 | 25 | 4 | Drugs (4) |
| CMF-18970 | CLEC14A | up-regulates | STAT3 | activates | R-1517 | 25 | 4 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, PEGINTERFERON LAMBDA-1A |
| CMF-18971 | CLEC14A | up-regulates | STAT3 | activates | R-1532 | 25 | 4 | Drugs (1) |
| CMF-19133 | PTPRR | up-regulates | STAT3 | activates | R-1521 | 25 | 3 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-20357 | CUX2 | up-regulates | STAT3 | activates | R-1530 | 25 | 8 | Drugs (5) |
| CMF-20360 | CUX2 | up-regulates | STAT3 | activates | R-1517 | 25 | 8 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, PEGINTERFERON LAMBDA-1A |
| CMF-20362 | CUX2 | up-regulates | STAT3 | activates | R-1532 | 25 | 8 | Drugs (1) |
| CMF-20977 | KRTAP4-7 | up-regulates | STAT3 | activates | R-1535 | 25 | 11 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-20978 | KRTAP4-7 | up-regulates | STAT3 | activates | R-1527 | 25 | 11 | Drugs (3) |
| CMF-20980 | KRTAP4-7 | up-regulates | STAT3 | activates | R-1525 | 25 | 11 | Drugs (4) |
| CMF-20981 | KRTAP4-7 | up-regulates | STAT3 | activates | R-1531 | 25 | 11 | Drugs (3) |
| CMF-20982 | KRTAP4-7 | up-regulates | STAT3 | activates | R-1517 | 25 | 11 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, PEGINTERFERON LAMBDA-1A |
| CMF-20983 | KRTAP4-7 | up-regulates | STAT3 | activates | R-1521 | 25 | 11 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-20984 | KRTAP4-7 | up-regulates | STAT3 | activates | R-1518 | 25 | 11 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-20985 | KRTAP4-7 | up-regulates | STAT3 | activates | R-1532 | 25 | 11 | Drugs (1) |
| CMF-21556 | MUC17 | up-regulates | STAT3 | activates | R-1535 | 25 | 8 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-21557 | MUC17 | up-regulates | STAT3 | activates | R-1527 | 25 | 8 | Drugs (3) |
| CMF-21558 | MUC17 | up-regulates | STAT3 | activates | R-1531 | 25 | 8 | Drugs (3) |
| CMF-21560 | MUC17 | up-regulates | STAT3 | activates | R-1517 | 25 | 8 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, PEGINTERFERON LAMBDA-1A |
| CMF-21561 | MUC17 | up-regulates | STAT3 | activates | R-1521 | 25 | 8 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-21562 | MUC17 | up-regulates | STAT3 | activates | R-1518 | 25 | 8 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-21563 | MUC17 | up-regulates | STAT3 | activates | R-1532 | 25 | 8 | Drugs (1) |
| CMF-22260 | IDH1 | down-regulates | STAT3 | activates | R-1530 | 25 | 19 | Drugs (5) |
| CMF-22262 | IDH1 | down-regulates | STAT3 | activates | R-1535 | 25 | 19 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-22263 | IDH1 | down-regulates | STAT3 | activates | R-1527 | 25 | 19 | Drugs (3) |
| CMF-22265 | IDH1 | down-regulates | STAT3 | activates | R-1525 | 25 | 19 | Drugs (4) |
| CMF-22267 | IDH1 | down-regulates | STAT3 | activates | R-1531 | 25 | 19 | Drugs (3) |
| CMF-22269 | IDH1 | down-regulates | STAT3 | activates | R-1517 | 25 | 19 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, PEGINTERFERON LAMBDA-1A |
| CMF-22271 | IDH1 | down-regulates | STAT3 | activates | R-1521 | 25 | 19 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-22272 | IDH1 | down-regulates | STAT3 | activates | R-1539 | 25 | 19 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-22273 | IDH1 | down-regulates | STAT3 | activates | R-1518 | 25 | 19 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-22274 | IDH1 | down-regulates | STAT3 | activates | R-1532 | 25 | 19 | Drugs (1) |
| CMF-23561 | TP53 | down-regulates | STAT3 | activates | R-1527 | 25 | 13 | Drugs (3) |
| CMF-23563 | TP53 | down-regulates | STAT3 | activates | R-1525 | 25 | 13 | Drugs (4) |
| CMF-23565 | TP53 | down-regulates | STAT3 | activates | R-1531 | 25 | 13 | Drugs (3) |
| CMF-23567 | TP53 | down-regulates | STAT3 | activates | R-1517 | 25 | 13 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)CINTREDEKIN BESUDOTOX, NIVOCASAN, EMRICASAN, PEGINTERFERON LAMBDA-1A |
| CMF-23569 | TP53 | down-regulates | STAT3 | activates | R-1521 | 25 | 13 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-23570 | TP53 | down-regulates | STAT3 | activates | R-1518 | 25 | 13 | Drugs (15) Regulator Drugs (0)Regulon Drugs (15)CALCIFEDIOL, BECOCALCIDIOL, PARICALCITOL, INECALCITOL, ERGOCALCIFEROL, CHOLECALCIFEROL, DOXERCALCIFEROL, CALCITRIOL, ELDECALCITOL, CALCIPOTRIENE, SEOCALCITOL, PEFCALCITOL, LUNACALCIPOL, DP001, ALFACALCIDOL |
| CMF-23571 | TP53 | down-regulates | STAT3 | activates | R-1532 | 25 | 13 | Drugs (1) |
| CMF-24421 | SEMA3C | down-regulates | STAT3 | activates | R-1535 | 25 | 9 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-24423 | SEMA3C | down-regulates | STAT3 | activates | R-1525 | 25 | 9 | Drugs (4) |
| CMF-24426 | SEMA3C | down-regulates | STAT3 | activates | R-1521 | 25 | 9 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-24427 | SEMA3C | down-regulates | STAT3 | activates | R-1532 | 25 | 9 | Drugs (1) |
| CMF-24581 | THADA | down-regulates | STAT3 | activates | R-1527 | 25 | 5 | Drugs (3) |
| CMF-24584 | THADA | down-regulates | STAT3 | activates | R-1539 | 25 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25981 | CTNNA2 | up-regulates | STAT3 | activates | R-1521 | 25 | 4 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-25982 | CTNNA2 | up-regulates | STAT3 | activates | R-1532 | 25 | 4 | Drugs (1) |
| CMF-26988 | HMCN1 | up-regulates | STAT3 | activates | R-1525 | 25 | 1 | Drugs (4) |
| CMF-28198 | REPIN1 | up-regulates | STAT3 | activates | R-1535 | 25 | 5 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-28199 | REPIN1 | up-regulates | STAT3 | activates | R-1531 | 25 | 5 | Drugs (3) |
| CMF-29749 | SLC5A7 | up-regulates | STAT3 | activates | R-1535 | 25 | 5 | Drugs (12) Regulator Drugs (0)Regulon Drugs (12)INTERFERON BETA-1B, ANIFROLUMAB, INTERFERON ALFA-2A, INTERFERON ALFA-2B, PEGINTERFERON ALFA-2B, INTERFERON ALFA-N3, ALBINTERFERON ALFA-2B, INTERFERON ALFACON-1, ROPEGINTERFERON ALFA-2B, PEGINTERFERON ALFA-2A, PEGINTERFERON BETA-1A, INTERFERON BETA-1A |
| CMF-29751 | SLC5A7 | up-regulates | STAT3 | activates | R-1521 | 25 | 5 | Drugs (6) Regulator Drugs (0)Regulon Drugs (6)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-29829 | ABCC9 | up-regulates | STAT3 | activates | R-1530 | 25 | 6 | Drugs (5) |
| CMF-29830 | ABCC9 | up-regulates | STAT3 | activates | R-1527 | 25 | 6 | Drugs (3) |
| CMF-29832 | ABCC9 | up-regulates | STAT3 | activates | R-1532 | 25 | 6 | Drugs (1) |
| CMF-31014 | ZNF676 | up-regulates | STAT3 | activates | R-1530 | 25 | 3 | Drugs (5) |
| CMF-31015 | ZNF676 | up-regulates | STAT3 | activates | R-1539 | 25 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |