Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

NKX6-1 - NK6 homeobox 1

Function

Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity).

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
4825 ENSG00000163623 NKX6-1 P78426

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000163623 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-01670MMRN1down-regulatesNKX6-1repressesR-2843203Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-01976PCDH9down-regulatesNKX6-1repressesR-2843202Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-02762BCAMup-regulatesNKX6-1repressesR-2843202Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-02984HFM1down-regulatesNKX6-1repressesR-2841201Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-03145EEF1A1down-regulatesNKX6-1repressesR-2843201Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-03325C14orf115down-regulatesNKX6-1repressesR-2849201Drugs (16)
CMF-03951DSPdown-regulatesNKX6-1repressesR-28442015Drugs (11)
CMF-03957DSPdown-regulatesNKX6-1repressesR-28522015Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-03961DSPdown-regulatesNKX6-1repressesR-28492015Drugs (16)
CMF-03962DSPdown-regulatesNKX6-1repressesR-28412015Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-04707SLC22A2down-regulatesNKX6-1repressesR-2852201Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-05146KCNH1down-regulatesNKX6-1repressesR-2852201Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-05404KDELC2down-regulatesNKX6-1repressesR-2843202Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-05982SIRPGdown-regulatesNKX6-1repressesR-2845202Drugs (19)
CMF-07942SLC27A2down-regulatesNKX6-1repressesR-2844204Drugs (11)
CMF-08052ABCC4down-regulatesNKX6-1repressesR-2845202Drugs (19)
CMF-08821FBLN2down-regulatesNKX6-1repressesR-2844208Drugs (11)
CMF-08824FBLN2down-regulatesNKX6-1repressesR-2845208Drugs (19)
CMF-08825FBLN2down-regulatesNKX6-1repressesR-2843208Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-08827FBLN2down-regulatesNKX6-1repressesR-2849208Drugs (16)
CMF-09225TANC2down-regulatesNKX6-1repressesR-2852205Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-10442ADAMTS10down-regulatesNKX6-1repressesR-2845205Drugs (19)
CMF-10443ADAMTS10down-regulatesNKX6-1repressesR-2843205Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-10444ADAMTS10down-regulatesNKX6-1repressesR-2849205Drugs (16)
CMF-11112ATF7IP2down-regulatesNKX6-1repressesR-2852203Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-11113ATF7IP2down-regulatesNKX6-1repressesR-2849203Drugs (16)
CMF-11114ATF7IP2down-regulatesNKX6-1repressesR-2841203Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-11895PALM2-AKAP2down-regulatesNKX6-1repressesR-2845203Drugs (19)
CMF-12181CELSR1down-regulatesNKX6-1repressesR-2844206Drugs (11)
CMF-12757RAG2down-regulatesNKX6-1repressesR-2843203Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-12758RAG2down-regulatesNKX6-1repressesR-2849203Drugs (16)
CMF-12904KCNS2down-regulatesNKX6-1repressesR-2852205Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-13701KELup-regulatesNKX6-1repressesR-2852203Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-14337RIMS2down-regulatesNKX6-1repressesR-2845202Drugs (19)
CMF-14338RIMS2down-regulatesNKX6-1repressesR-2843202Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-14535GPR112down-regulatesNKX6-1repressesR-2843202Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-15555TAS2R41down-regulatesNKX6-1repressesR-2849205Drugs (16)
CMF-15556TAS2R41down-regulatesNKX6-1repressesR-2841205Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-15901TUBBP5down-regulatesNKX6-1repressesR-2843201Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-16081NFIXdown-regulatesNKX6-1repressesR-2844206Drugs (11)
CMF-16084NFIXdown-regulatesNKX6-1repressesR-2852206Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-16085NFIXdown-regulatesNKX6-1repressesR-2849206Drugs (16)
CMF-16470SUSD5down-regulatesNKX6-1repressesR-2852208Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-16472SUSD5down-regulatesNKX6-1repressesR-2843208Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-16474SUSD5down-regulatesNKX6-1repressesR-2849208Drugs (16)
CMF-16475SUSD5down-regulatesNKX6-1repressesR-2841208Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-17041EPPK1down-regulatesNKX6-1repressesR-2843201Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-18923TEAD1down-regulatesNKX6-1repressesR-2844202Drugs (11)
CMF-19174PTPRRdown-regulatesNKX6-1repressesR-2849206Drugs (16)
CMF-19175PTPRRdown-regulatesNKX6-1repressesR-2841206Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-20599ADCY1down-regulatesNKX6-1repressesR-2852203Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-21069KRTAP4-7down-regulatesNKX6-1repressesR-2845207Drugs (19)
CMF-21070KRTAP4-7down-regulatesNKX6-1repressesR-2852207Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-21071KRTAP4-7down-regulatesNKX6-1repressesR-2843207Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-21073KRTAP4-7down-regulatesNKX6-1repressesR-2849207Drugs (16)
CMF-21074KRTAP4-7down-regulatesNKX6-1repressesR-2841207Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-22006CARD6down-regulatesNKX6-1repressesR-2843202Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-24529SEMA3Cup-regulatesNKX6-1repressesR-2845208Drugs (19)
CMF-24530SEMA3Cup-regulatesNKX6-1repressesR-2852208Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-24531SEMA3Cup-regulatesNKX6-1repressesR-2843208Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

NERAMEXANE, NERAMEXANE MESYLATE

CMF-24532SEMA3Cup-regulatesNKX6-1repressesR-2849208Drugs (16)
CMF-24533SEMA3Cup-regulatesNKX6-1repressesR-2841208Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-25885PIK3CAdown-regulatesNKX6-1repressesR-2841203Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-26330CHGBdown-regulatesNKX6-1repressesR-2849202Drugs (16)
CMF-27146SLC44A5down-regulatesNKX6-1repressesR-2841201Drugs (2)

Regulator Drugs (0)

Regulon Drugs (2)

TAS0612, OCRIPLASMIN

CMF-27640ANKRD36down-regulatesNKX6-1repressesR-2852201Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-29321C12orf51down-regulatesNKX6-1repressesR-2845202Drugs (19)
CMF-31057PNPLA7down-regulatesNKX6-1repressesR-2845203Drugs (19)