Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

ZEB1 - zinc finger E-box binding homeobox 1

Function

Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

Uniprot Browser

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
6935	ENSG00000148516	ZEB1	P37275

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000148516 as Regulator

ID	Mutation	Role	Regulator	Role	Regulon	# downstream regulons	# diffexp regulons	Drugs
CMF-00283	SPTA1	down-regulates	ZEB1	activates	R-2125	13	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NERAMEXANE, NERAMEXANE MESYLATE
CMF-00424	MUC17	down-regulates	ZEB1	activates	R-2125	13	1	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NERAMEXANE, NERAMEXANE MESYLATE
CMF-03311	PLCD1	down-regulates	ZEB1	activates	R-2125	13	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NERAMEXANE, NERAMEXANE MESYLATE
CMF-06606	CACNA1D	up-regulates	ZEB1	represses	R-2134	13	2	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ABATACEPT, BELATACEPT, GALIXIMAB
CMF-06865	ATRX	up-regulates	ZEB1	represses	R-2127	13	3	Drugs (86) Regulator Drugs (0) Regulon Drugs (86) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, SCH-708980, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, CANAKINUMAB, MELOXICAM, BROMFENAC SODIUM, RILONACEPT, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, MEDI-5117, GEVOKIZUMAB, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, CLAZAKIZUMAB, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, OLOKIZUMAB, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, SILTUXIMAB, MRA 003 US, ACEMETACIN, PARECOXIB SODIUM, IBUPROFEN SODIUM, LUTIKIZUMAB, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, PF-04236921, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, SIRUKUMAB, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, POLMACOXIB, ZILTIVEKIMAB
CMF-06866	ATRX	up-regulates	ZEB1	represses	R-2123	13	3	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BRENSOCATIB
CMF-08784	FBLN2	up-regulates	ZEB1	activates	R-2125	13	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NERAMEXANE, NERAMEXANE MESYLATE
CMF-10833	PKD1L2	up-regulates	ZEB1	represses	R-2134	13	4	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ABATACEPT, BELATACEPT, GALIXIMAB
CMF-13027	PTPN3	down-regulates	ZEB1	activates	R-2125	13	3	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NERAMEXANE, NERAMEXANE MESYLATE
CMF-16551	RBM19	down-regulates	ZEB1	activates	R-2125	13	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NERAMEXANE, NERAMEXANE MESYLATE
CMF-22511	IDH1	up-regulates	ZEB1	represses	R-2127	13	9	Drugs (86) Regulator Drugs (0) Regulon Drugs (86) IBUPROFEN, PIRPROFEN, PHENYLBUTAZONE, SCH-708980, CIMICOXIB, ACETAMINOPHEN, OXYPHENBUTAZONE, CELECOXIB, CANAKINUMAB, MELOXICAM, BROMFENAC SODIUM, RILONACEPT, ACECLOFENAC, OLSALAZINE, LORNOXICAM, FLURBIPROFEN, DIPYRONE, FENOPROFEN, APRICOXIB, MEDI-5117, GEVOKIZUMAB, NAPROXEN SODIUM, DEXKETOPROFEN, PARECOXIB, ASPIRIN, ESFLURBIPROFEN, CLAZAKIZUMAB, ALOXIPRIN, ETORICOXIB, INDOPROFEN, KETOROLAC, INDOMETHACIN SODIUM, BENZYDAMINE, LUMIRACOXIB, NAPROXEN, DICLOFENAC EPOLAMINE, OLOKIZUMAB, FENOPROFEN CALCIUM, MECLOFENAMIC ACID, OLSALAZINE SODIUM, APAZONE, NABUMETONE, ROFECOXIB, MESALAMINE, SILTUXIMAB, MRA 003 US, ACEMETACIN, PARECOXIB SODIUM, IBUPROFEN SODIUM, LUTIKIZUMAB, BALSALAZIDE DISODIUM, NEPAFENAC, DICLOFENAC POTASSIUM, IBUPROFEN LYSINE, PIROXICAM, ETODOLAC, SUPROFEN, PF-04236921, SULFASALAZINE, MECLOFENAMATE SODIUM, GW-406381, LOXOPROFEN, DICLOFENAC SODIUM, BENZYDAMINE HYDROCHLORIDE, TOLMETIN SODIUM, KETOROLAC TROMETHAMINE, DEXIBUPROFEN, SULINDAC, KETOPROFEN, BALSALAZIDE, NAPROXCINOD, TOLMETIN, DICLOFENAC, BISMUTH SUBSALICYLATE, MEFENAMIC ACID, GLAFENINE, DIFLUNISAL, SIRUKUMAB, BROMFENAC, NAPROXEN ETEMESIL, INDOMETHACIN, OXAPROZIN, IGURATIMOD, VALDECOXIB, POLMACOXIB, ZILTIVEKIMAB
CMF-22512	IDH1	up-regulates	ZEB1	represses	R-2123	13	9	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BRENSOCATIB
CMF-23503	CUBN	up-regulates	ZEB1	represses	R-2134	13	3	Drugs (3) Regulator Drugs (0) Regulon Drugs (3) ABATACEPT, BELATACEPT, GALIXIMAB
CMF-24399	EPHA10	up-regulates	ZEB1	activates	R-2125	13	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NERAMEXANE, NERAMEXANE MESYLATE
CMF-25036	IQSEC3	up-regulates	ZEB1	represses	R-2123	13	3	Drugs (1) Regulator Drugs (0) Regulon Drugs (1) BRENSOCATIB
CMF-25037	IQSEC3	up-regulates	ZEB1	activates	R-2125	13	3	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NERAMEXANE, NERAMEXANE MESYLATE
CMF-26734	RB1	down-regulates	ZEB1	activates	R-2125	13	3	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NERAMEXANE, NERAMEXANE MESYLATE
CMF-26848	VAV1	up-regulates	ZEB1	activates	R-2125	13	2	Drugs (2) Regulator Drugs (0) Regulon Drugs (2) NERAMEXANE, NERAMEXANE MESYLATE

ZEB1 - zinc finger E-box binding homeobox 1

Function

Causal Mechanistic Flows with ENSG00000148516 as Regulator

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