Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
HMGA1 - high mobility group AT-hook 1
Function
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 3159 | ENSG00000137309 | HMGA1 | P17096 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows with ENSG00000137309 as Regulator
| ID | Mutation | Role | Regulator | Role | Regulon | # downstream regulons | # diffexp regulons | Drugs |
|---|---|---|---|---|---|---|---|---|
| CMF-01068 | ZNF292 | down-regulates | HMGA1 | activates | R-1073 | 16 | 8 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-01071 | ZNF292 | down-regulates | HMGA1 | activates | R-1068 | 16 | 8 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-01072 | ZNF292 | down-regulates | HMGA1 | activates | R-1081 | 16 | 8 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-01075 | ZNF292 | down-regulates | HMGA1 | activates | R-1067 | 16 | 8 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-05759 | ADAMTS19 | down-regulates | HMGA1 | activates | R-1068 | 16 | 1 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-09262 | RP1 | down-regulates | HMGA1 | activates | R-1073 | 16 | 4 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-09264 | RP1 | down-regulates | HMGA1 | activates | R-1068 | 16 | 4 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-09265 | RP1 | down-regulates | HMGA1 | activates | R-1081 | 16 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-11513 | OR2T6 | down-regulates | HMGA1 | activates | R-1073 | 16 | 2 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-11621 | CHSY3 | down-regulates | HMGA1 | activates | R-1081 | 16 | 1 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-12027 | DSC3 | up-regulates | HMGA1 | activates | R-1071 | 16 | 3 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17520 | CNTNAP3 | down-regulates | HMGA1 | activates | R-1071 | 16 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17945 | PRPF40B | down-regulates | HMGA1 | activates | R-1073 | 16 | 7 | Drugs (4) Regulator Drugs (0)Regulon Drugs (4)ALEPLASININ, COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN, VESENCUMAB |
| CMF-17946 | PRPF40B | down-regulates | HMGA1 | activates | R-1071 | 16 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17948 | PRPF40B | down-regulates | HMGA1 | activates | R-1081 | 16 | 7 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-17950 | PRPF40B | down-regulates | HMGA1 | activates | R-1067 | 16 | 7 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-20495 | BCL11A | down-regulates | HMGA1 | activates | R-1068 | 16 | 3 | Drugs (9) Regulator Drugs (0)Regulon Drugs (9)ATN-161, CINTREDEKIN BESUDOTOX, NIVOCASAN, NATALIZUMAB, FIRATEGRAST, EMRICASAN, VOLOCIXIMAB, PEGINTERFERON LAMBDA-1A, ABITUZUMAB |
| CMF-21314 | GRIK3 | up-regulates | HMGA1 | activates | R-1071 | 16 | 4 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-21317 | GRIK3 | up-regulates | HMGA1 | activates | R-1067 | 16 | 4 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-22014 | MOCS3 | down-regulates | HMGA1 | activates | R-1067 | 16 | 2 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |
| CMF-24192 | OR4K5 | down-regulates | HMGA1 | activates | R-1081 | 16 | 2 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25862 | PIK3CA | up-regulates | HMGA1 | activates | R-1081 | 16 | 5 | Drugs (0) Regulator Drugs (0)Regulon Drugs (0) |
| CMF-25864 | PIK3CA | up-regulates | HMGA1 | activates | R-1067 | 16 | 5 | Drugs (7) Regulator Drugs (0)Regulon Drugs (7)LANATOSIDE C, DIGOXIN, ACETYLDIGITOXIN, OCRIPLASMIN, DIGITOXIN, DESLANOSIDE, ISTAROXIME |