Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

LMX1B - LIM homeobox transcription factor 1 beta

Function

Transcription factor involved in the regulation of podocyte-expressed genes (PubMed:24042019, PubMed:28059119). Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
4010 ENSG00000136944 LMX1B O60663

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows with ENSG00000136944 as Regulator

IDMutationRoleRegulatorRoleRegulon# downstream regulons# diffexp regulonsDrugs
CMF-00189PCLOdown-regulatesLMX1BrepressesR-2929112Drugs (17)
CMF-01262KRT37down-regulatesLMX1BrepressesR-2929113Drugs (17)
CMF-01263KRT37down-regulatesLMX1BrepressesR-2931113Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-01878CYP4F8down-regulatesLMX1BrepressesR-2927113Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-01943PCDH9down-regulatesLMX1BrepressesR-2927112Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-02103ABCA4down-regulatesLMX1BrepressesR-2931115Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-02818MST1down-regulatesLMX1BrepressesR-2931113Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-03123EEF1A1down-regulatesLMX1BrepressesR-2927112Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-03785DSPdown-regulatesLMX1BrepressesR-2931116Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-04157ESPNPdown-regulatesLMX1BrepressesR-2931111Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-08428COL17A1down-regulatesLMX1BrepressesR-2931113Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-08429COL17A1down-regulatesLMX1BrepressesR-2927113Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-09415ZIC4down-regulatesLMX1BrepressesR-2927112Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-09484DOCK11down-regulatesLMX1BrepressesR-2929113Drugs (17)
CMF-09486DOCK11down-regulatesLMX1BrepressesR-2927113Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-09608OR9G9down-regulatesLMX1BrepressesR-2929114Drugs (17)
CMF-09610OR9G9down-regulatesLMX1BrepressesR-2927114Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-10140EML2down-regulatesLMX1BrepressesR-2931114Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-10143EML2down-regulatesLMX1BrepressesR-2927114Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-10625ITIH5Ldown-regulatesLMX1BrepressesR-2931112Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-10831PKD1L2down-regulatesLMX1BrepressesR-2931112Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-11157ODF4down-regulatesLMX1BrepressesR-2929111Drugs (17)
CMF-11820GPX5down-regulatesLMX1BrepressesR-2931112Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-11836SKIV2Ldown-regulatesLMX1BrepressesR-2929111Drugs (17)
CMF-11864PALM2-AKAP2down-regulatesLMX1BrepressesR-2929113Drugs (17)
CMF-12117PCDH7down-regulatesLMX1BrepressesR-2929111Drugs (17)
CMF-13166SLC26A8down-regulatesLMX1BrepressesR-2931115Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-13301ADAM22down-regulatesLMX1BrepressesR-2929111Drugs (17)
CMF-13975CDKN2Cdown-regulatesLMX1BrepressesR-2929112Drugs (17)
CMF-14327RIMS2down-regulatesLMX1BrepressesR-2927111Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-14908SDHAP3down-regulatesLMX1BrepressesR-2929112Drugs (17)
CMF-15015TGdown-regulatesLMX1BrepressesR-2927114Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-15479ALLCdown-regulatesLMX1BrepressesR-2929111Drugs (17)
CMF-15511NCAPGdown-regulatesLMX1BrepressesR-2929112Drugs (17)
CMF-15620DCHS2down-regulatesLMX1BrepressesR-2929113Drugs (17)
CMF-15970PRIC285down-regulatesLMX1BrepressesR-2931111Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-17061MAGEA6down-regulatesLMX1BrepressesR-2929111Drugs (17)
CMF-17379TBC1D8down-regulatesLMX1BrepressesR-2927113Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-17882TGM3down-regulatesLMX1BrepressesR-2927112Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-20402CUX2down-regulatesLMX1BrepressesR-2931113Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-21162ADAM30down-regulatesLMX1BrepressesR-2927113Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-21329GRIK3down-regulatesLMX1BrepressesR-2927113Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-21944FAT1down-regulatesLMX1BrepressesR-2929113Drugs (17)
CMF-21946FAT1down-regulatesLMX1BrepressesR-2927113Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-23046AOX1down-regulatesLMX1BrepressesR-2931111Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-23719TP53up-regulatesLMX1BrepressesR-2929117Drugs (17)
CMF-23723TP53up-regulatesLMX1BrepressesR-2927117Drugs (1)

Regulator Drugs (0)

Regulon Drugs (1)

BELZUTIFAN

CMF-25638SVOPLdown-regulatesLMX1BrepressesR-2929113Drugs (17)
CMF-26426SPAG5down-regulatesLMX1BrepressesR-2931112Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-28941NPHS1down-regulatesLMX1BrepressesR-2929112Drugs (17)
CMF-29294C12orf51down-regulatesLMX1BrepressesR-2929114Drugs (17)
CMF-29345RPL13AP6down-regulatesLMX1BrepressesR-2929112Drugs (17)
CMF-30351MAGEB6down-regulatesLMX1BrepressesR-2931112Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-30444KIAA1467down-regulatesLMX1BrepressesR-2931111Drugs (0)

Regulator Drugs (0)

Regulon Drugs (0)

CMF-30941MUC2down-regulatesLMX1BrepressesR-2929111Drugs (17)